|Source:||The roots of Panax ginseng C. A. Mey.|
|Biological Activity or Inhibitors:|| 1. Ginsenoside Rk1 has anti-tumor activity in human hepatocellular carcinoma cells through inhibition of telomerase activity and induction of apoptosis.
2. Ginsenoside Rk1 has anti-platelet aggregation activity.
3. Ginsenoside Rk1 may be a promising compound to induce apoptosis through both extrinsic and intrinsic pathways in SK-MEL-2 cells.
4. Ginsenoside Rk1 can strongly inhibit permeability induced by VEGF, advance glycation end-product, thrombin, or histamine in human retinal endothelial cells, it reduces the vessel leakiness of retina in a diabetic mouse model; this anti-permeability activity of Rk1 is correlated with enhanced stability and positioning of tight junction proteins at the boundary between cells; Rk1 induces phosphorylation of myosin light chain and cortactin, which are critical regulators for the formation of the cortical actin ring structure and endothelial barrier; suggests that ginsenoside Rk1 could be exploited as a novel prototype compound for the prevention of human diseases that are characterized by vascular leakage.
|Solvent:||DMSO, Pyridine, Methanol, Ethanol, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||1.6532 mL||8.2658 mL||16.5317 mL||33.0633 mL||41.3291 mL|
|5 mM||0.3306 mL||1.6532 mL||3.3063 mL||6.6127 mL||8.2658 mL|
|10 mM||0.1653 mL||0.8266 mL||1.6532 mL||3.3063 mL||4.1329 mL|
|50 mM||0.0331 mL||0.1653 mL||0.3306 mL||0.6613 mL||0.8266 mL|
|100 mM||0.0165 mL||0.0827 mL||0.1653 mL||0.3306 mL||0.4133 mL|
Arch Pharm Res. 2002 Aug;25(4):428-32.
|Three new dammarane glycosides from heat processed ginseng.[Pubmed: 12214849]|
|Three new dammarane glycosides were isolated from the processed ginseng (SG; Sun Ginseng). Their structure were determined to be 3beta,12beta-dihydroxydammar-20(21),24-diene-3-O-beta-D-glucopyranosyl(1 --> 2)-beta-D-glucopyranoside; 3beta,12beta-dihydroxydammar-20(21),24-diene-3-O-beta-D- glucopyranoside and 3beta,6alpha,12beta-trihydroxydammar-20(21),24-diene-6-O-beta-D-glucopyranoside based on spectroscopic evidences. The compounds were named as Ginsenoside Rk1, Ginsenoside Rk2, and ginsenoside Rk3 respectively.|