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    Murrayone
    Information
    CAS No. 19668-69-0 Price $288 / 10mg
    Catalog No.CFN98505Purity>=98%
    Molecular Weight258.27Type of CompoundCoumarins
    FormulaC15H14O4Physical DescriptionWhite cryst.
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
    Citing Use of our Products
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $131.0 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Universidad Veracuzana (Mexico)
  • Medical University of Gdansk (Poland)
  • University of Wisconsin-Madison (USA)
  • Semmelweis Unicersity (Hungary)
  • Donald Danforth Plant Science C... (USA)
  • Utah State University (USA)
  • Institute of Pathophysiology Me... (Austria)
  • University of Liège (Belgium)
  • Technical University of Denmark (Denmark)
  • The Ohio State University (USA)
  • Charles Sturt University (Denmark)
  • More...
  • Package
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    Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anti-platelet aggregation Compound Library
  • Coumarins Compound Library
  • Biological Activity
    Description: Murrayone can significantly inhibit the abnormal increase of platelet aggregation induced by ADP.
    In vitro:
    Zhongguo Zhong Yao Za Zhi. 2014 Nov;39(22):4356-9.
    Coumarins from Leonurus japonicus and their anti-platelet aggregative activity[Pubmed: 25850267]
    Chemical constituents of Leonurus japonicus were isolated and purified by a combination of various chromatographic techniques including column chromatography over silica gel, Sephadex LH-20, MCI, and Rp C18.
    METHODS AND RESULTS:
    Structures of the isolates were determined by spectroscopic analysis as 10 coumarins: bergapten (1), xanthotoxin (2), isopimpinellin (3), isogosferal (4), imperatorin (5), meransin hydrate(6), isomeranzin(7), Murrayone(8) , auraptenol(9), and osthol(10). In addition to compound 9, the others were isolated from the genus Leonurus for the first time.
    CONCLUSIONS:
    In the in vitro assay, compounds 4 and 8 significantly inhibited the abnormal increase of platelet aggregation induced by ADP.
    Murrayone Description
    Source: The leaves of Murraya koenigii
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
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    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.8719 mL 19.3596 mL 38.7192 mL 77.4383 mL 96.7979 mL
    5 mM 0.7744 mL 3.8719 mL 7.7438 mL 15.4877 mL 19.3596 mL
    10 mM 0.3872 mL 1.936 mL 3.8719 mL 7.7438 mL 9.6798 mL
    50 mM 0.0774 mL 0.3872 mL 0.7744 mL 1.5488 mL 1.936 mL
    100 mM 0.0387 mL 0.1936 mL 0.3872 mL 0.7744 mL 0.968 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.