|Source:||The peel of Citrus maxima|
|Biological Activity or Inhibitors:||1. Naringin inhibits some drug-metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2, which may result in drug-drug interactions.
2. Naringin has protective effects against cognitive dysfunction and reduces diabetes-induced neuropathy in rats.
3. Naringin is an inhibitor of vascular endothelial growth factor (VEGF) release, which causes angiogenesis.
4. Naringin has antioxidant properties in its cardioprotective effects in various models, by providing cardioprotection by inducing the phosphorylation of ERK1/2, PKCδ, and AKT, which subsequently activated Nrf2 and its downstream genes.
|Solvent:||Pyridine, Methanol, Ethanol, etc.|
|Storage:||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
|After receiving:||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.|
|1 mg||5 mg||10 mg||20 mg||25 mg|
|1 mM||1.7226 mL||8.6128 mL||17.2256 mL||34.4513 mL||43.0641 mL|
|5 mM||0.3445 mL||1.7226 mL||3.4451 mL||6.8903 mL||8.6128 mL|
|10 mM||0.1723 mL||0.8613 mL||1.7226 mL||3.4451 mL||4.3064 mL|
|50 mM||0.0345 mL||0.1723 mL||0.3445 mL||0.689 mL||0.8613 mL|
|100 mM||0.0172 mL||0.0861 mL||0.1723 mL||0.3445 mL||0.4306 mL|
Drug Chem Toxicol. 2015 May 5:1-5.
|Anti-genotoxic effect of naringin against bleomycin-induced genomic damage in human lymphocytes in vitro.[Pubmed: 25941869]|
|Naringin is a flavonoid found in grapefruit and other citrus fruits that shows antioxidant activity. The aim of the present study was to determine the anti-genotoxic and protective effects of Naringin on the chemotherapeutic/radiomimetic agent bleomycin (BLM) in human blood lymphocyte cultures in vitro using micronucleus test and chromosomal aberrations (CA) assay. We tested the three doses of Naringin (1, 2, 3 µg/mL) and a single dose of BLM (20 µg/mL). BLM significantly increased the total CAs and micronucleus frequency at a concentration of 20 µg/mL. Naringin did not show any toxicity in doses of 1, 2, and 3 µg/mL. Combined treatments of BLM and Naringin (2 and 3 µg/mL) significantly reduced micronucleus formation. Naringin dose-dependently decreased the total chromosome aberrations frequency induced by BLM. These results indicate that Naringin could prevent BLM (20 µg/mL)-induced genotoxicity.|
Food Chem Toxicol. 2015 Apr 17;81:160-170.
|The antioxidant and antigenotoxic properties of citrus phenolics limonene and naringin.[Pubmed: 25896273]|
|Phenolic compounds not only contribute to the sensory qualities of fruits and vegetables but also exhibit several health protective properties. Limonene and Naringin are the most popular phenolics found in Citrus plants. In this study, we investigated the antioxidant capacities of limonene and Naringin by the trolox equivalent antioxidant capacity (TEAC) assay and the cytotoxic effects by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay in Chinese hamster fibroblast (V79) cells. The genotoxic potentials of limonene and Naringin were evaluated by micronucleus (MN) and alkaline COMET assays in human lymphocytes and V79 cells. Limonene and Naringin, were found to have antioxidant activities at concentrations of 2-2000 µM and 5-2000 µM respectively. IC50 values of limonene and Naringin were found to be 1265 µM and 9026 µM, respectively. Limonene at the concentrations below 10,000 µM and Naringin at the all concentrations studied, have not exerted genotoxic effects in lymphocytes and in V79 cells. Limonene and Naringin at all concentrations revealed a reduction in the frequency of MN and DNA damage induced by H2O2.|
J Pharm Bioallied Sci. 2015 Apr-Jun;7(2):121-7.
|Effect of naringin on hemodynamic changes and left ventricular function in renal artery occluded renovascular hypertension in rats.[Pubmed: 25883516]|
|BACKGROUND: Renal artery occlusion (RAO) induced hypertension is a major health problem associated with structural and functional variations of the renal and cardiac vasculature. Naringin a flavanone glycoside derived possesses metal-chelating, antioxidant and free radical scavenging properties. OBJECTIVE: The objective of this study was to investigate the antihypertensive activity of Naringin in RAO induced hypertension in rats. MATERIAL AND METHODS: Male Wistar rats (180-200 g) were divided into five groups Sham, RAO, Naringin (20, 40 and 80 mg/kg). Animals were pretreated with Naringin (20, 40 and 80 mg/kg p.o) for 4 weeks. On the last day of the experiment, left renal artery was occluded with renal bulldog clamp for 4 h. After assessment of hemodynamic and left ventricular function various biochemical (superoxide dismutase [SOD], glutathione [GSH] and malondialdehyde [MDA]) and histological parameters were determined in the kidney. RESULTS: RAO group significantly (P < 0.001) increased hemodynamic parameters at 15, 30 and 45 min of clamp removal. Naringin (40 and 80 mg/kg) treated groups showed a significant decrease in hemodynamic parameters at 15 min. after clamp removal that remained sustained for 60 min. Naringin (40 and 80 mg/kg) treated groups showed significant improvement in left ventricular function at 15, 30 and 45 min after clamp removal. Alteration in level of SOD, GSH and MDA was significantly restored by Naringin (40 and 80 mg/kg) treatment. It also reduced histological aberration induced in kidney by RAO.|
Biochem Biophys Res Commun. 2014 Sep 26;452(3):629-35.
|Naringin prevents ovariectomy-induced osteoporosis and promotes osteoclasts apoptosis through the mitochondria-mediated apoptosis pathway.[Pubmed: 25181344]|
|Naringin, the primary active compound of the traditional Chinese medicine Rhizoma drynariae, possesses many pharmacological activities. The present study is an effort to explore the anti-osteoporosis potential of Naringin in vivo and in vitro. In vivo, we used ovariectomized rats to clarify the mechanisms by which Naringin anti-osteoporosis. In vitro, we used osteoclasts to investigate Naringin promotes osteoclasts apoptosis. Naringin was effective at enhancing BMD, trabecular thickness, bone mineralization, and mechanical strength in a dose-dependent manner. The result of RT-PCR analysis revealed that Naringin down-regulated the mRNA expression levels of BCL-2 and up-regulated BAX, caspase-3 and cytochrome C. In addition, Naringin significantly reduced the bone resorption area in vitro. These findings suggest that Naringin promotes the apoptosis of osteoclasts by regulating the activity of the mitochondrial apoptosis pathway and prevents OVX-induced osteoporosis in rats.|