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    Neomangiferin
    Information
    CAS No. 64809-67-2 Price $168 / 20mg
    Catalog No.CFN98122Purity>=98%
    Molecular Weight584.48Type of CompoundXanthones
    FormulaC25H28O16Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Neomangiferin exhibits antidiabetic and antiosteoporotic actions; it has beneficial effects on high fat diet-induced nonalcoholic fatty liver disease in rats, it also modulates the Th17/Treg balance and ameliorates colitis in mice.
    Targets: PPAR | LDL | TNF-α | NF-kB | IL Receptor | COX | NOS | Fatty Acid Synthase
    In vitro:
    Phytomedicine. 2016 Feb 15;23(2):131-40.
    Neomangiferin modulates the Th17/Treg balance and ameliorates colitis in mice.[Pubmed: 26926174 ]
    Anemarrhena asphodeloides (Liliaceae family) and Mangifera indica L. (Anacardiaceae family) contain Neomangiferin as the main active constituent and have been used to treat inflammation, asthma, and pain. A preliminary study found that Neomangiferin inhibited splenic T cell differentiation into Th17 cells and promoted Treg cell production in vitro. Therefore, we examined its anti-colitic effects in vitro and in vivo.
    METHODS AND RESULTS:
    Splenocytes isolated from C57BL/6J mice were treated with Neomangiferin. Colitis was either induced in vivo by intrarectal administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS) to C57BL/6J mice or occurred spontaneously in colitis caused by interleukin (IL)-10 knockout at age of 13 weeks. Mice were treated daily with Neomangiferin or sulfasalazine. Inflammatory markers, cytokines, enzymes and transcription factors were measured by enzyme-linked immunosorbent assay, immunoblot, and flow cytometry. Neomangiferin suppressed retinoic acid receptor-related orphan receptor gamma t (RORγt) and IL-17 expression in IL-6/transforming growth factor β-stimulated Th17 splenocytes and increased IL-10 expression in vitro. Mouse TNBS-induced colon shortening, macroscopic score, and myeloperoxidase activity were inhibited by Neomangiferin, which also reduced TNBS-induced activation of nuclear factor-κB and extracellular signal-regulated kinases, as well as expression of inducible nitric oxide synthase and cyclooxygenase-2. In addition, Neomangiferin inhibited TNBS-induced expression of tumor necrosis factor-α, IL-17, IL-6, and IL-1β, and increased IL-10 expression. Neomangiferin inhibited TNBS-induced differentiation to Th17 cells and promoted the development of Treg cells. Moreover, in IL-10(-/-) mice, Neomangiferin inhibited colonic myeloperoxidase activity, suppressed Th17 cell differentiation, and reduced levels of TNF-α and IL-17.
    CONCLUSIONS:
    Neomangiferin may restore the balance between Th17/Treg cells by suppressing IL-17 and RORγt expression and inducing IL-10 and forkhead box P3 expression, thus ameliorating colitis.
    In vivo:
    Int Immunopharmacol. 2015 Mar;25(1):218-28.
    Beneficial effects of neomangiferin on high fat diet-induced nonalcoholic fatty liver disease in rats.[Pubmed: 25661699]
    This study was carried out to determine the effect and mechanism of action of Neomangiferin (NG) on high-fat diet-induced nonalcoholic fatty liver disease (NAFLD) in rats.
    METHODS AND RESULTS:
    NAFLD rats were randomly assigned into several groups of equal number. NG (50, 25mg/kg·day(-1) BW) and lipanthyl (PT, 5mg/kg·day(-1) BW) were given to the NAFLD rats, respectively. In the study, serum lipids, metabolic rate, liver fat, liver lipids and histology were examined. To further investigate the molecular mechanism of the effect of NG on NAFLD, expression levels of mRNA and protein for peroxisome proliferator-activated receptor α (PPARα), fatty acid transport protein 2 (FATP2), long-chain-fatty-acid - CoA ligase 1 (ACSL1) and carnitine palmitoyltransferase 1a (CPT1a) in the liver were determined by Real Time-PCR and western blot analysis, respectively. NG administration significantly reduced the final body weight, liver fat accumulation, and serum triglyceride (TG), total cholesterol (TC) concentrations, low-density lipoprotein cholesterol (LDL-C), glucose (GLU) levels, and hepatic TG, TC, malondialdehyde (MDA) levels, but increased serum high-density lipoprotein cholesterol (HDL-C) and hepatic superoxide dismutase (SOD) levels. NG upregulated the mRNA and protein expression of PPARα and CPT1a, but downregulated the mRNA and protein expression of FATP2 and ACSL1 in the liver.
    CONCLUSIONS:
    These results suggested that NG can regulate NAFLD partly by modulating the expression levels of genes involved in FFA uptake and lipid oxidation.
    Neomangiferin Description
    Source: The herbs of Mangifera indica L.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7109 mL 8.5546 mL 17.1092 mL 34.2185 mL 42.7731 mL
    5 mM 0.3422 mL 1.7109 mL 3.4218 mL 6.8437 mL 8.5546 mL
    10 mM 0.1711 mL 0.8555 mL 1.7109 mL 3.4218 mL 4.2773 mL
    50 mM 0.0342 mL 0.1711 mL 0.3422 mL 0.6844 mL 0.8555 mL
    100 mM 0.0171 mL 0.0855 mL 0.1711 mL 0.3422 mL 0.4277 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Sep Sci. 2010 Jan;33(1):31-6.
    Preparative isolation of neomangiferin and mangiferin from Rhizoma anemarrhenae by high-speed countercurrent chromatography using ionic liquids as a two-phase solvent system modifier.[Pubmed: 19950352]

    METHODS AND RESULTS:
    A preparative high-speed countercurrent chromatography method for isolation and purification of Neomangiferin and mangiferin from Rhizoma anemarrhenae was successfully established by using ionic liquids as the modifier of the two-phase solvent system. Neomangiferin and mangiferin were purified from the crude extract of R. anemarrhenae by using ethyl acetate-water-[C(4)mim][PF(6)] (5:5:0.2 v/v) as two-phase solvent system. In total, 22.5 mg of Neomangiferin and 70.6 mg of mangiferin were obtained from 150 mg of the crude extract. The purities of Neomangiferin and mangiferin were 97.2 and 98.1%, respectively, as determined by HPLC.
    CONCLUSIONS:
    The chemical structures of the isolated compounds were identified by (1)H-NMR and (13)C-NMR.