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    Neoprzewaquinone A
    Information
    CAS No. 630057-39-5 Price $413 / 5mg
    Catalog No.CFN97087Purity>=98%
    Molecular Weight556.6 Type of CompoundDiterpenoids
    FormulaC36H28O6Physical DescriptionRed powder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)
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    Neoprzewaquinone A Description
    Source: The roots of Salvia miltiorrhiza
    Biological Activity or Inhibitors: 1. Neoprzewaquinone A has algicidal effect on M. aeruginosa , with EC50 of 4.68 mg /L, the potential inhibition mechanisms are neo-przewaquinone A caused M. aeruginosa cells morphologic damage or lysis, increased malondialdehyde content and decreased the soluble protein content, total antioxidant and superoxide dismutase activity, and significantly inhibited three photosynthesis-related genes (psaB, psbD, and rbcL).
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7966 mL 8.9831 mL 17.9662 mL 35.9324 mL 44.9156 mL
    5 mM 0.3593 mL 1.7966 mL 3.5932 mL 7.1865 mL 8.9831 mL
    10 mM 0.1797 mL 0.8983 mL 1.7966 mL 3.5932 mL 4.4916 mL
    50 mM 0.0359 mL 0.1797 mL 0.3593 mL 0.7186 mL 0.8983 mL
    100 mM 0.018 mL 0.0898 mL 0.1797 mL 0.3593 mL 0.4492 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Neoprzewaquinone A References Information
    Citation [1]

    Chemosphere. 2013 Oct;93(6):997-1004.

    Algicidal activity of Salvia miltiorrhiza Bung on Microcystis aeruginosa--towards identification of algicidal substance and determination of inhibition mechanism.[Pubmed: 23810520]
    Column chromatography and bioassay-guided fractionation methods were carried out to yield Neoprzewaquinone A, which was identified by spectral analysis. The EC50 of Neoprzewaquinone A on M. aeruginosa were 4.68 mg L(-1). In addition, neo-przewaquinone A showed relatively higher security on Chlorella pyrenoidosa and Scenedesmus obliquus, with the EC50 values of 14.78 and 10.37 mg L(-1), respectively. For the potential inhibition mechanisms, Neoprzewaquinone A caused M. aeruginosa cells morphologic damage or lysis, increased malondialdehyde content and decreased the soluble protein content, total antioxidant and superoxide dismutase activity, and significantly inhibited three photosynthesis-related genes (psaB, psbD, and rbcL). The results demonstrated the algicidal effect of Neoprzewaquinone A on M. aeruginosa and provided the possible inhibition mechanisms.
    Citation [2]

    Yao Xue Xue Bao. 2003 May;38(5):354-7.

    Chemical constituents in the roots of Salvia przewalskii Maxim.[Pubmed: 12958839]
    To investigate the chemical composition of the root of Salvia przewalskii Maxim. METHODS: Compounds were isolated by silica gel column chromatography. Structures of these compounds were elucidated by spectral analysis (EI-MS, FAB-MS, 1HNMR, 13CNMR, 1H-1H COSY, 1H-13C COSY, HMBC, NOESY) and phytochemical properties. RESULTS: Eight compounds were isolated and identified as: tanshinone II-A (I), crypotanshinone (II), przewaquinone A (III), sugiol (IV), ursolic acid (V), 2 alpha, 3 alpha-dihydroxy urs-12-ene-28-acid (VI), oleanolic acid (VII), and Neoprzewaquinone A (VIII). CONCLUSION: Neoprzewaquinone A is a new compound, and compound II, IV, V, VI and VII are isolated from this plant for the first time.