ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $404.6 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Molecules.2015, 20(10):19172-88Phytomedicine.2015, 22(4):498-503Tumour Biol.2015, 36(9):7027-34J Pharm Biomed Anal2016, 118:183-194BMC Complement Altern Med.2016, 16:213J of the Korean Society of Food S...2016...Food Analytical Methods...2017...Molecules.2017, 22(2)
JPC-Journal of Planar Chromatogra...2017...Pharmacol Rep.2017, 69(6):1224-1231The Pharmaceutical Society of Jap...2018...Molecules.2018, 23(11):E2837The Journal of Agromedicine and M...2018...Biochem Biophys Res Commun....2018...J Cancer.2019, 10(23):5843-5851Biomed Pharmacother.2019, 116:108987
J Pharm Biomed Anal.2019, 164:119-127J Ethnopharmacol.2019, 228:132-141Phytother Res.2019, 33(7):1784-1793Phytomedicine.2019, 56:48-56Int Immunopharmacol.2019, 71:361-371Sci Rep.2019, 9(1):4342Nutrients2020, 12(2):488
Our products had been exported to the following research institutions and universities, And still growing.
University of Otago (New Zealand)Sapienza University of Rome (Italy)University of Padjajaran (Indonesia)Monash University Malaysia (Malaysia)
Wroclaw Medical University (Poland)University of Stirling (United Kingdom)National Chung Hsing University (Taiwan)Universidad Veracuzana (Mexico)
Sant Gadge Baba Amravati Univer... (India)Universiti Putra Malaysia(UPM) (Malaysia)Semmelweis Unicersity (Hungary)
Related Screening Libraries
|| Notoginsenoside Fc has perfect anti-platelet aggregatory effect. |
|J Pharm Biomed Anal. 2015 May 10;109:150-7. |
|Pharmacokinetics, bioavailability, and metabolism of Notoginsenoside Fc in rats by liquid chromatography/electrospray ionization tandem mass spectrometry.[Pubmed: 25770412]|
|Notoginsenoside Fc (NGFc) is a protopanaxadiol-type (PPD-type) saponin from Panax notoginseng, which has perfect anti-platelet aggregatory effect. However, its pharmacokinetics and metabolism in vivo remain unknown.|
METHODS AND RESULTS:
In this study, a simple and sensitive liquid chromatography/electrospray ionization tandem mass spectrometry (LC-MS/MS) method was first developed for the determination of NGFc in rat plasma. After methanol-mediated protein precipitation, separation was achieved on a C18 column with MS detection operated in negative SRM mode at m/z 604.56→m/z 783.90 and m/z 799.93→m/z 637.64 for NGFc and IS, respectively. The assay was linear over the concentration range (r>0.995) with the LLOQ of 0.002μg/ml. The intra- and inter-day precisions (R.S.D.) were 2.45-12.36% and 3.67-14.22%, respectively; whereas accuracy ranged from (R.R.) 93.90% to 99.41%. The extraction recovery, stability, and matrix effect were within the acceptable limits.
The validated LC-MS/MS method was successfully applied to the pre-clinical pharmacokinetic studies of NGFc in rat. After oral and intravenous administration, NGFc showed dose-independent pharmacokinetic behaviors with a t1/2 of >22h and its oral bioavailability was 0.10-0.14%. In addition, a total of 10 metabolites were detected and structurally characterized by UPLC-Q/TOF-MS technique, which suggested that deglycosylation was the major metabolic pathway for NGFc in rats.
Notoginsenoside Fc Description
||The roots of Panax notoginseng
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Zhongguo Zhong Yao Za Zhi. 1992 Oct;17(10):611-3, 639-40 concl. |
|Saponins in the fruit pedicels of Panax notoginseng (Burk.) F.H. Chen (continue).[Pubmed: 1294178]|
|Six saponins were isolated from the fruit pedicels of Panax notoginseng. |
METHODS AND RESULTS:
Five of them were identified as gypenoside-XVII, -XV, ginsenoside-Rb1, and notoginsenoside-Fc, -Fa on the basis of chemical methods, spectroscopic analysis and comparison with authentic standards.
Quantitative determination of the major saponins in fruit pedicels from the plant was made by thin layer chromatography-densitometry.