• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Natural Products
    Notoginsenoside Fc
    CAS No. 88122-52-5 Price $198 / 20mg
    Catalog No.CFN93283Purity>=98%
    Molecular Weight1211.4Type of CompoundTriterpenoids
    FormulaC58H98O26Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $404.6 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • University of Otago (New Zealand)
  • Sapienza University of Rome (Italy)
  • University of Padjajaran (Indonesia)
  • Monash University Malaysia (Malaysia)
  • Wroclaw Medical University (Poland)
  • University of Stirling (United Kingdom)
  • National Chung Hsing University (Taiwan)
  • Universidad Veracuzana (Mexico)
  • Sant Gadge Baba Amravati Univer... (India)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Semmelweis Unicersity (Hungary)
  • More...
  • Package
    Featured Products
    Delta 5-avenasterol

    Catalog No: CFN92239
    CAS No: 18472-36-1
    Price: $510/5mg
    Sanggenone K

    Catalog No: CFN92416
    CAS No: 86450-77-3
    Price: $533/5mg

    Catalog No: CFN92400
    CAS No: 606-12-2
    Price: $40/20mg
    Skullcapflavone II

    Catalog No: CFN92216
    CAS No: 55084-08-7
    Price: $318/10mg

    Catalog No: CFN92425
    CAS No: 86361-55-9
    Price: $218/5mg

    Catalog No: CFN90458
    CAS No: 66791-77-3
    Price: $288/20mg
    Polygalaxanthone III

    Catalog No: CFN90208
    CAS No: 162857-78-5
    Price: $138/20mg
    Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anti-platelet aggregation Compound Library
  • Triterpenoids Compound Library
  • PAFR Inhibitor Library
  • Biological Activity
    Description: Notoginsenoside Fc has perfect anti-platelet aggregatory effect.
    Targets: PAFR
    In vivo:
    J Pharm Biomed Anal. 2015 May 10;109:150-7.
    Pharmacokinetics, bioavailability, and metabolism of Notoginsenoside Fc in rats by liquid chromatography/electrospray ionization tandem mass spectrometry.[Pubmed: 25770412]
    Notoginsenoside Fc (NGFc) is a protopanaxadiol-type (PPD-type) saponin from Panax notoginseng, which has perfect anti-platelet aggregatory effect. However, its pharmacokinetics and metabolism in vivo remain unknown.
    In this study, a simple and sensitive liquid chromatography/electrospray ionization tandem mass spectrometry (LC-MS/MS) method was first developed for the determination of NGFc in rat plasma. After methanol-mediated protein precipitation, separation was achieved on a C18 column with MS detection operated in negative SRM mode at m/z 604.56→m/z 783.90 and m/z 799.93→m/z 637.64 for NGFc and IS, respectively. The assay was linear over the concentration range (r>0.995) with the LLOQ of 0.002μg/ml. The intra- and inter-day precisions (R.S.D.) were 2.45-12.36% and 3.67-14.22%, respectively; whereas accuracy ranged from (R.R.) 93.90% to 99.41%. The extraction recovery, stability, and matrix effect were within the acceptable limits.
    The validated LC-MS/MS method was successfully applied to the pre-clinical pharmacokinetic studies of NGFc in rat. After oral and intravenous administration, NGFc showed dose-independent pharmacokinetic behaviors with a t1/2 of >22h and its oral bioavailability was 0.10-0.14%. In addition, a total of 10 metabolites were detected and structurally characterized by UPLC-Q/TOF-MS technique, which suggested that deglycosylation was the major metabolic pathway for NGFc in rats.
    Notoginsenoside Fc Description
    Source: The roots of Panax notoginseng
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Recent ChemFaces New Products and Compounds
    Magnaldehyde B

    Catalog No: CFN95075
    CAS No: 92829-72-6
    Price: $413/5mg

    Catalog No: CFN96557
    CAS No: 491-74-7
    Price: $188/20mg

    Catalog No: CFN98887
    CAS No: 531-44-2
    Price: $168/20mg
    Buddlenoid A

    Catalog No: CFN95025
    CAS No: 142750-32-1
    Price: $368/5mg

    Catalog No: CFN95091
    CAS No: 168035-01-6
    Price: $288/5mg

    Catalog No: CFN98757
    CAS No: 482-39-3
    Price: $288/20mg

    Catalog No: CFN91876
    CAS No: 30557-81-4
    Price: $433/10mg
    Orcinol 1-O-beta-D-apiofuranosyl-(...

    Catalog No: CFN95109
    CAS No: 868557-54-4
    Price: $338/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 0.8255 mL 4.1275 mL 8.2549 mL 16.5098 mL 20.6373 mL
    5 mM 0.1651 mL 0.8255 mL 1.651 mL 3.302 mL 4.1275 mL
    10 mM 0.0825 mL 0.4127 mL 0.8255 mL 1.651 mL 2.0637 mL
    50 mM 0.0165 mL 0.0825 mL 0.1651 mL 0.3302 mL 0.4127 mL
    100 mM 0.0083 mL 0.0413 mL 0.0825 mL 0.1651 mL 0.2064 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Structure Identification:
    Zhongguo Zhong Yao Za Zhi. 1992 Oct;17(10):611-3, 639-40 concl.
    Saponins in the fruit pedicels of Panax notoginseng (Burk.) F.H. Chen (continue).[Pubmed: 1294178]
    Six saponins were isolated from the fruit pedicels of Panax notoginseng.
    Five of them were identified as gypenoside-XVII, -XV, ginsenoside-Rb1, and notoginsenoside-Fc, -Fa on the basis of chemical methods, spectroscopic analysis and comparison with authentic standards.
    Quantitative determination of the major saponins in fruit pedicels from the plant was made by thin layer chromatography-densitometry.