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    Officinalisinin I
    Information
    CAS No. 57944-18-0 Price $248 / 20mg
    Catalog No.CFN90692Purity>=98%
    Molecular Weight921.07Type of CompoundSteroids
    FormulaC45H76O19Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Officinalisinin Ⅰcan effectively reduce the blood glucose and protect nerve injuryin diabetic mice.
    In vivo:
    China Journal of Traditional Chinese Medicine & Pharmacy, 2017 (2) :782-785.
    Study on hypoglycemic mechanism and central nerve protection of Officinalisinin Ⅰ in Rhizoma Anemarrhenae[Reference: WebLink]
    To study the hypoglycemic effect of Officinalisinin Ⅰin Rhizoma Anemarrhenae on diabetes, and discuss the hypoglycemic mechanism and protective effect on diabetic nephropathy.
    METHODS AND RESULTS:
    Glucose tolerance was measured in model mice induced by oral administration of alloxan.Inhibition of glycosidase activity was tested in vitro.GLP-1 was detected after fasting in diabetic mice.The levels of BDNF and GSH-PX in serum were detected by enzyme-linked immunosorbent assay(ELISA) after 20 days of medication.Officinalisinin I has the functions of lowering blood glucose and significantly improving the glucose tolerance of diabetic mice.In the experiment, the glycosidase inhibitor pathway was eliminated, andby promoting the generation of GLP-1 and BDNF and increasing the activity of GSH-PX Officinalisinin I achieves the hypoglycemic and neuroprotective effect.
    CONCLUSIONS:
    Officinalisinin I can effectively reduce the blood glucose and protect nerve injuryin diabetic mice.
    Officinalisinin I Description
    Source: The rhizomes of Anemarrhena asphodeloides Bunge
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.0857 mL 5.4285 mL 10.8569 mL 21.7139 mL 27.1423 mL
    5 mM 0.2171 mL 1.0857 mL 2.1714 mL 4.3428 mL 5.4285 mL
    10 mM 0.1086 mL 0.5428 mL 1.0857 mL 2.1714 mL 2.7142 mL
    50 mM 0.0217 mL 0.1086 mL 0.2171 mL 0.4343 mL 0.5428 mL
    100 mM 0.0109 mL 0.0543 mL 0.1086 mL 0.2171 mL 0.2714 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.