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    Phyllanthin
    Phyllanthin
    Information
    CAS No. 10351-88-9 Price
    Catalog No.CFN99050Purity>=98%
    Molecular Weight418.5 Type of CompoundLignans
    FormulaC24H34O6Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Our products had been exported to the following research institutions and universities, And still growing.
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  • Package
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    Biological Activity
    Description: 1. Phyllanthin is widely used as hepatoprotective and antigenotoxic and inhibit function of P-gp.
    Targets: NF-kB | TGF-β/Smad | P-gp
    Phyllanthin Description
    Source: The herb of Phyllanthus niruri L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi: 10.1016/j.phymed.2017.12.030.

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3895 mL 11.9474 mL 23.8949 mL 47.7897 mL 59.7372 mL
    5 mM 0.4779 mL 2.3895 mL 4.779 mL 9.5579 mL 11.9474 mL
    10 mM 0.2389 mL 1.1947 mL 2.3895 mL 4.779 mL 5.9737 mL
    50 mM 0.0478 mL 0.2389 mL 0.4779 mL 0.9558 mL 1.1947 mL
    100 mM 0.0239 mL 0.1195 mL 0.2389 mL 0.4779 mL 0.5974 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Phyllanthin References Information
    Citation [1]

    Toxicol Ind Health. 2014 May 9.

    Phyllanthin inhibits CCl4-mediated oxidative stress and hepatic fibrosis by down-regulating TNF-α/ NF-κB and pro-fibrotic factor TGF-β1 mediated inflammatory signaling.[Pubmed: 24817434]
    Hepatic fibrosis is an important outcome of chronic liver injury and results in excess synthesis and accumulation of extracellular matrix (ECM) components. Phyllanthin (PLN) isolated from Phyllanthus amarus exhibits strong antioxidative property and protects HepG2 cells from carbon tetrachloride (CCl4)-induced experimental toxicity. The present study reports the antifibrotic potential of PLN. The in vivo inhibitory effect of PLN on CCl4-mediated lipid peroxidation and important profibrotic mediator transforming growth factor β1 and on predominant ECM components collagen and fibronectin were also studied. The results show that PLN acts by suppressing the expression of inflammatory cytokine tumor necrosis factor-α and prevents activation of nuclear factor-κB in hepatic tissue. Our study highlights the molecular mechanism responsible for the antifibrotic efficacy of PLN.
    Citation [2]

    J Pharm Pharmacol. 2013 Feb;65(2):292-9.

    Phyllanthin and hypophyllanthin inhibit function of P-gp but not MRP2 in Caco-2 cells.[Pubmed: 23278697]
    Phyllanthin and hypoPhyllanthin directly inhibited P-gp activity and did not interfere with MRP2 activity. It was likely that both Phyllanthin and hypoPhyllanthin could reversibly inhibit P-gp function.
    Citation [3]

    Chem Biol Interact. 2009 Oct 30;181(3):351-8.

    Isolation, characterization and antioxidative effect of phyllanthin against CCl4-induced toxicity in HepG2 cell line.[Pubmed: 19576190]
    The protective effect of P. amarus extract and Phyllanthin was studied on CCl4-induced toxicity in human hepatoma HepG2 cell line. The results indicated that CCl4 treatment caused a significant decrease in cell viability. In addition, the toxin treatment initiated lipid peroxidation (LPO), caused leakage of enzymes like alanine transaminase (ALT) and lactate dehydrogenase (LDH) with a significant decrease in glutathione (GSH) levels. It was observed that Phyllanthin effectively alleviated the changes induced by CCl4 in a concentration-dependent manner, with much smaller strengths as compared to P. amarus extract.