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    Pseudolaric acid B-O-beta-D-glucopyranoside
    Pseudolaric acid B-O-beta-D-glucopyranoside
    Information
    CAS No. 98891-41-9 Price
    Catalog No.CFN90726Purity>=98%
    Molecular Weight594.6Type of CompoundDiterpenoids
    FormulaC29H38O13Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Pseudolaric acid B-O-beta-D-glucopyranoside is a natural product from Pseudolarix amabilis.
    In vivo:
    Yao Xue Xue Bao. 2014 Aug;49(8):1169-74.
    Metabolic pathway and metabolites of total diterpene acid isolated from Pseudolarix kaempferi.[Pubmed: 25322560]
    The preliminary metabolic profile of total diterpene acid (TDA) isolated from Pseudolarix kaempferi was investigated by using in vivo and in vitro tests.
    METHODS AND RESULTS:
    Pseudolaric acid C2 (PC2) was identified as the predominant metabolite in plasma, urine, bile and feces after both oral and intravenous administrations to rats using HPLC-UV and HPLC-ESI/MS(n), and demethoxydeacetoxypseudolaric acid B (DDPB), a metabolite proposed to be the glucoside of PC2 (PC2G), as well as pseudolaric acid C (PC), pseudolaric acid A (PA), Pseudolaric acid A-O-beta-D-glucopyranoside (PAG), Pseudolaric acid B-O-beta-D-glucopyranoside (PBG) and deacetylpseudolaric acid A (DPA) originated from TDA could also be detected. It was demonstrated by tests that the metabolism of TDA is independent of intestinal microflora, and neither of pepsin and trypsin is in charge of metabolism of TDA, TDA is also stable in both pH environments of gastric tract and intestinal tract. The metabolites of TDA in whole blood in vitro incubation were found to be PC2, DDPB and PC2G, which demonstrated that the metabolic reaction of TDA in vivo is mainly occurred in blood and contributed to be the hydrolysis of plasma esterase to ester bond, as well as the glucosylation reaction.
    CONCLUSIONS:
    These results clarified the metabolic pathway of TDA for the first time, which is of great significance to the in vivo active form and acting mechanism research of P. kaempferi.
    Pseudolaric acid B-O-beta-D-glucopyranoside Description
    Source: The root barks of Pseudolarix amabilis
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6818 mL 8.409 mL 16.818 mL 33.6361 mL 42.0451 mL
    5 mM 0.3364 mL 1.6818 mL 3.3636 mL 6.7272 mL 8.409 mL
    10 mM 0.1682 mL 0.8409 mL 1.6818 mL 3.3636 mL 4.2045 mL
    50 mM 0.0336 mL 0.1682 mL 0.3364 mL 0.6727 mL 0.8409 mL
    100 mM 0.0168 mL 0.0841 mL 0.1682 mL 0.3364 mL 0.4205 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J. Nat. Prod., 2002, 65 (7), pp 1041–1044
    Five New Diterpenoids from Pseudolarix kaempferi[Reference: WebLink]

    METHODS AND RESULTS:
    Five new diterpenoids, pseudolaric acids F (1), G (2), and H (3), 2‘,3‘-dihydroxy-1‘-propoxypseudolarate B (4), and 6‘-O-acetylpseudolaric acid B O-β-d-glucopyranoside (5), along with nine known diterpenoids, pseudolaric acids A, B, and C1, deacetylpseudolaric acid C2, deacetylpseudolaric acid A, methyl pseudolarate A, methyl pseudolarate B, pseudolaric acid A-O-β-d-glucopyranoside, and Pseudolaric acid B-O-beta-D-glucopyranoside, were isolated from the root bark of Pseudolarix kaempferi.
    CONCLUSIONS:
    Their structures and stereochemistry were elucidated mainly by spectral data, especially 2D NMR techniques.