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Pseudolaric acid B-O-beta-D-glucopyranoside
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More articles cited ChemFaces products.
ARPN Journal of Eng.& Applied Sci.4, Feb. 2016 Int J Mol Sci. 2018 Jan 23;Tropical J. of Pha. ResearchNo 3 (2017) SBRAS2016(12)Sci Rep. Jan. 2018
Int J Mol Med.2015 Dec 28.Molecules. 2018 Jan 24;Front Pharmacol. 2017 Sep 29;Sci Rep. 2018 Jan 11;Evidence-Based Complementary & Alternative Med.2017
The Korea Society of Pharmacognosy.2014Mol Med Rep.2015 Sep 21Cell11 Jan. 2018;Biol Pharm Bull.2017;40(6)
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|| Pseudolaric acid B-O-beta-D-glucopyranoside is a natural product from Pseudolarix amabilis.|
|Yao Xue Xue Bao. 2014 Aug;49(8):1169-74. |
|Metabolic pathway and metabolites of total diterpene acid isolated from Pseudolarix kaempferi.[Pubmed: 25322560]|
|The preliminary metabolic profile of total diterpene acid (TDA) isolated from Pseudolarix kaempferi was investigated by using in vivo and in vitro tests.
METHODS AND RESULTS:
Pseudolaric acid C2 (PC2) was identified as the predominant metabolite in plasma, urine, bile and feces after both oral and intravenous administrations to rats using HPLC-UV and HPLC-ESI/MS(n), and demethoxydeacetoxypseudolaric acid B (DDPB), a metabolite proposed to be the glucoside of PC2 (PC2G), as well as pseudolaric acid C (PC), pseudolaric acid A (PA), Pseudolaric acid A-O-beta-D-glucopyranoside (PAG), Pseudolaric acid B-O-beta-D-glucopyranoside (PBG) and deacetylpseudolaric acid A (DPA) originated from TDA could also be detected. It was demonstrated by tests that the metabolism of TDA is independent of intestinal microflora, and neither of pepsin and trypsin is in charge of metabolism of TDA, TDA is also stable in both pH environments of gastric tract and intestinal tract. The metabolites of TDA in whole blood in vitro incubation were found to be PC2, DDPB and PC2G, which demonstrated that the metabolic reaction of TDA in vivo is mainly occurred in blood and contributed to be the hydrolysis of plasma esterase to ester bond, as well as the glucosylation reaction.
These results clarified the metabolic pathway of TDA for the first time, which is of great significance to the in vivo active form and acting mechanism research of P. kaempferi.
Pseudolaric acid B-O-beta-D-glucopyranoside Description
||The root barks of Pseudolarix amabilis
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|J. Nat. Prod., 2002, 65 (7), pp 1041–1044 |
|Five New Diterpenoids from Pseudolarix kaempferi[Reference: WebLink]|
METHODS AND RESULTS:
Five new diterpenoids, pseudolaric acids F (1), G (2), and H (3), 2‘,3‘-dihydroxy-1‘-propoxypseudolarate B (4), and 6‘-O-acetylpseudolaric acid B O-β-d-glucopyranoside (5), along with nine known diterpenoids, pseudolaric acids A, B, and C1, deacetylpseudolaric acid C2, deacetylpseudolaric acid A, methyl pseudolarate A, methyl pseudolarate B, pseudolaric acid A-O-β-d-glucopyranoside, and Pseudolaric acid B-O-beta-D-glucopyranoside, were isolated from the root bark of Pseudolarix kaempferi.
Their structures and stereochemistry were elucidated mainly by spectral data, especially 2D NMR techniques.