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    Pyracrenic acid
    Pyracrenic acid
    CAS No. 80832-44-6 Price
    Catalog No.CFN89164Purity>=98%
    Molecular Weight618.85Type of CompoundTriterpenoids
    FormulaC39H54O6Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Pyracrenic acid Description
    Source: The aerial roots of Ficus microcarpa.
    Biological Activity or Inhibitors: 1. Pyracrenic acid shows significant cytotoxic activities against human cancer cells COLO 205 and AGS.
    2. Pyracrenic acid is a potent elastase inhibitor with an IC50 value of 1.5 mg/mL.
    3. Pyracrenic acid shows DPPH radical scavenging activity.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6159 mL 8.0795 mL 16.159 mL 32.318 mL 40.3975 mL
    5 mM 0.3232 mL 1.6159 mL 3.2318 mL 6.4636 mL 8.0795 mL
    10 mM 0.1616 mL 0.808 mL 1.6159 mL 3.2318 mL 4.0398 mL
    50 mM 0.0323 mL 0.1616 mL 0.3232 mL 0.6464 mL 0.808 mL
    100 mM 0.0162 mL 0.0808 mL 0.1616 mL 0.3232 mL 0.404 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Pyracrenic acid References Information
    Citation [1]

    Zhong Yao Cai. 2012 Jun;35(6):904-8.

    Chemical constituents from the aerial roots of Ficus microcarpa.[Pubmed: 23236824]
    To study the chemical constituents of the aerial roots of Ficus microcarpa. METHODS: The compounds were isolated and purified by column chromatographic methods on silica gel and Sephadex LH-20. Their structures were elucidated by physicochemical properties and spectral data. RESULTS: 12 compounds were isolated from the 95% ethanol extract. Their structures were idenified as 3beta-hydroxy-11-oxours-12-ene (1), 3beta-acetoxy-11-oxours-12-ene (2), oleanic acid (3), 3beta-hydroxy-oleana-11,13 (18)-dien-28-oic acid (4), betulinic acid (5), Pyracrenic acid (6), platanic acid (7), isowigtheone (8), myrsininone A (9), derrone (10), alpinumisoflavone (11) and caffeic acid methyl ester (12), respectively. CONCLUSION: Compounds 4, 6, 12 are obtained from this genus for the first time, compounds 1, 7 - 11 are isolated from this plant for the first time.
    Citation [2]

    Chem Biodivers. 2008 Apr;5(4):565-74.

    Cytotoxic triterpenoids from the root bark of Helicteres angustifolia.[Pubmed: 18421748 ]
    Three new triterpenoids, 3beta-acetoxy-27-[(E)-cinnamoyloxy]lup-20(29)-en-28-oic acid methyl ester (1), 3beta-acetoxy-27-[(4-hydroxybenzoyl)oxy]lup-20(29)-en-28-oic acid (2), and 3beta-acetoxy-27-[(4-hydroxybenzoyl)oxy]olean-12-en-28-oic acid methyl ester (3), together with nine known triterpenoids, 4-12, were isolated from the root bark of Helicteres angustifolia. The structures of these compounds were established on the basis of spectroscopic methods including 2D-NMR experiments. All twelve compounds were tested for their cytotoxic activities against human colorectal cancer (COLO 205), human hepatoma (Hep G2), and human gastric cancer (AGS) cell lines in vitro. Among them, compounds 2, 3, 3beta-O-[(E)-coumaroyl]betulinic acid (6), and Pyracrenic acid (7) showed significant cytotoxic activities against human cancer cells COLO 205 and AGS.
    Citation [3]

    Journal of Medicinal Plant Research, 2009, 3(11):914-920.

    Compounds with elastase inhibition and free radical scavenging activities from Callistemon lanceolatus.[Reference: WebLink]
    Bioassay-guided investigation of the stems of Callistemon lanceolatus led to the isolation of five compounds such as betulinic acid (1), Pyracrenic acid (2), arjunolic acid (3), catechin (4), and piceatannol (5). Their structures were elucidated on the basis of spectral studies as well as by comparison with literature data. Elastase inhibition and DPPH radical scavenging activities wereinvestigated for the isolated compounds. Among these, Pyracrenic acid (2) was identified as a potent elastase inhibitor with an IC50 value of 1.5 mg/mL, more active than the control compound, oleanolic acid (IC50 = 3.0 mg/mL). With regard to antioxidative studies, strong to moderate DPPH radical scavenging activities were observed with Pyracrenic acid (2), catechin (4) and piceatanol (5).