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    Rediocide C
    Rediocide C
    Information
    CAS No. 677277-98-4 Price
    Catalog No.CFN97156Purity>=98%
    Molecular Weight814.9 Type of CompoundDiterpenoids
    FormulaC46H54O13Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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  • Biological Activity
    Description: Rediocide C exhibits antimycobacterial activity, with the MIC value of 3.84 uM; it also exhibits potent activity against D. pteronyssinus with respective LC50 values of 5.59 microg/cm2.
    Targets: Antifection
    In vitro:
    Chem Pharm Bull (Tokyo). 2005 Feb;53(2):241-3.
    Acaricidal daphnane diterpenoids from Trigonostemon reidioides (KURZ) CRAIB roots.[Pubmed: 15684528]

    METHODS AND RESULTS:
    A new daphnane diterpenoid, rediocide F (1), was isolated together with three known compounds, rediocides A (2), C (3) and E (4), from the hexane extract of Trigonostemon reidioides roots by bioassay-guided fractionation for acaricidal activity on Dermatophagoides pteronyssinus, Thai common house dust mite. The structure of rediocide F (1) was established as the demethyl analog of Rediocide C (3) on the basis of spectral analysis.
    CONCLUSIONS:
    Compounds 1-4 exhibited potent activity against D. pteronyssinus with respective LC50 values of 2.53, 0.78, 5.59 and 0.92 microg/cm2.
    Rediocide C Description
    Source: The herbs of Trigonostemon reidioides (Kurz) Craib.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    IF=36.216(2019)

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.2271 mL 6.1357 mL 12.2714 mL 24.5429 mL 30.6786 mL
    5 mM 0.2454 mL 1.2271 mL 2.4543 mL 4.9086 mL 6.1357 mL
    10 mM 0.1227 mL 0.6136 mL 1.2271 mL 2.4543 mL 3.0679 mL
    50 mM 0.0245 mL 0.1227 mL 0.2454 mL 0.4909 mL 0.6136 mL
    100 mM 0.0123 mL 0.0614 mL 0.1227 mL 0.2454 mL 0.3068 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Tetrahedron , 2017,73( 12):1594–1601.
    Terpenoids with potent antimycobacterial activity against Mycobacterium tuberculosis from Trigonostemon reidioides roots[Reference: WebLink]
    Phytochemical investigation of Trigonostemon reidioides roots led to the isolation of fourteen compounds. These included six new diterpenoids, trigonoreidons A−F (1−6), together with eight known diterpenoids 7−14.
    METHODS AND RESULTS:
    The structures of the new compounds were elucidated by spectroscopic techniques and the absolute configuration at the asymmetric carbon was determined by the modified Mosher's method. The structure of trigonoreidon B (2) was confirmed by X-ray crystallographic analysis. The known compounds were identified by comparison of the spectroscopic and physical data with those of reported values. The isolated compounds were evaluated for antimycobacterial activity against Mycobacterium tuberculosis.
    CONCLUSIONS:
    Among the compounds that exhibited antimycobacterial activity, the diterpenoids Rediocide C (12) and rediocide G (14) were the most active compounds, with the MIC value of 3.84 μM.