ChemFaces is a professional high-purity natural products manufacturer.
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
BMC Complement Altern Med.2014, 14:352Int J Mol Sci. 2014, 15(5):8443-57Asian Journal of Chemistry...2014...Mol Med Rep.2014, 9(5):1653-9Sci. Rep.2015, 14-23Tumour Biol.2015, 36(9):7027-34Molecules.2017, 22(2)J Food Compos Anal2017, 62:197-204
J Sci Food Agric.2017, 97(5):1656-1662Nutrients.2018, 10(10)Evid Based Complement Alternat Me...2018...Anticancer Res.2018, 38(4):2127-2135Sci Adv.2018, 4(10)Nat Commun.2019, 10(1):5169J Med Food.2019, 22(10):1067-1077Food Engineering Progress...2019...
Molecules.2019, 24(24),4583Molecules.2019, 24(4):E709Phytomedicine.2019, 58:152893Int Immunopharmacol.2019, 71:22-31Saudi Pharm J2020, 10.1016J Pharmaceut Biomed2020, 178:112894Antioxidants (Basel).2020, 9(2): E119
Our products had been exported to the following research institutions and universities, And still growing.
Srinakharinwirot University (Thailand)Worcester Polytechnic Institute (USA)University of Madras (India)University of Padjajaran (Indonesia)
University of Hull (United Kingdom)Texas A&M University (USA)University of Virginia (USA)National Hellenic Research Foun... (Greece)
Charles University in Prague (Czech Republic)Kyung Hee University (Korea)Funda??o Universitária de Dese... (Brazil)
Related Screening Libraries
|| Safflor Yellow A protects cultured rat cardiomyocytes against A/R injury, maybe via inhibiting cellular oxidative stress and apoptosis.|
||Bcl-2/Bax | Caspase | SOD|
|Acta Pharmacol Sin. 2013 Apr;34(4):487-95. |
|Safflor yellow A protects neonatal rat cardiomyocytes against anoxia/reoxygenation injury in vitro.[Pubmed: 23396376]|
|To investigate the effects of Safflor Yellow A (SYA), a flavonoid extracted from Carthamus tinctorius L, on cultured rat cardiomyocytes exposed to anoxia/reoxygenation (A/R). |
METHODS AND RESULTS:
Primary cultured neonatal rat cardiomyocytes were exposed to anoxia for 3 h followed by reoxygenation for 6 h. The cell viability was measured using MTT assay. The releases of lactate dehydrogenase (LDH) and creatine kinase (CK), level of malondialdehyde (MDA), and activities of glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) were analyzed. Hoechst 33258 staining and changes in Bcl-2/Bax ratio and caspase 3 activity were used to examine A/R-induced apoptosis. The A/R exposure markedly decreased the viability of cardiomyocytes, suppressed the activities of SOD, GSH, CAT and GSH-Px, and Bcl-2 protein expression. Meanwhile, the A/R exposure markedly increased the release of LDH and CK, and MDA production in the cardiomyocytes, and increased the rate of apoptosis, caspase 3 activity, Bax protein expression. Pretreatment with Safflor Yellow A (40, 60 and 80 nmol/L) concentration-dependently blocked the A/R-induced changes in the cardiomyocytes. Pretreatment of the cardiomyocytes with the antioxidant N-acetylcysteine (NAC, 200 μmol/L) produced protective effects that were comparable to those caused by Safflor Yellow A (80 nmol/L).
Safflor Yellow A protects cultured rat cardiomyocytes against A/R injury, maybe via inhibiting cellular oxidative stress and apoptosis.
Safflor Yellow A Description
||The stigma of Crocus sativus L.
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Yao Xue Xue Bao. 2004 Mar;39(3):217-9. |
|Study on distribution of safflor yellow A in tissues of mice.[Pubmed: 15171659]|
|To study the distributive character of Safflor Yellow A in mice.
METHODS AND RESULTS:
A RP-HPLC method for the determination of Safflor Yellow A in tissues was established and applied to determine Safflor Yellow A in biological samples.
After iv injection of Safflor Yellow A in mice, the AUC of Safflor Yellow A was hightest in plasma, followed by kidney, liver, lung, heart, spleen. But it was not found in the brain.
The distribution of Safflor Yellow A in the body is abroad and the speed of its process is swift.