ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
More articles cited ChemFaces products.
Sci Rep. 2017 Oct 11;Cell Physiol Biochem. 2017;44(4);JPCMarch 16, 2017Nutrients.2017 Dec 29;Front Pharmacol. 2017 Apr 25;
Evid Based Complement Alternat Med. 2016 May 24; Mol Med Rep.2015 Sep 21The Korea Society of Pharmacognosy.2014Int. Conference on Med. Sci. and Bio.2017;BMC Complement Altern Med.2016 Jul 13
Int J Mol Sci. 2014 May 13;15(5):8443-57.Current Pharmaceutical AnalysisIssue 5, 2017Scientific Reports2015 August 26 Org Biomol Chem. 2017 Jul 25.
Our products had been exported to the following research institutions and universities, And still growing.
University of Liège (Belgium)Kyushu University (Japan)Universiti Kebangsaan Malaysia (Malaysia)Northeast Normal University Chan... (China)
Max-Planck-Insitut (Germany)Calcutta University (India)Deutsches Krebsforschungszentrum (Germany)Hamdard University (India)
University of Sao Paulo (Brazil)Ateneo de Manila University (Philippines)Fraunhofer-Institut für Molekul... (Germany)
||Peimine has good anti-inflammatory effects in vivo, it inhibits the production of inflammatory cytokines induced by LPS through blocking MAPKs and NF-κB signaling pathways. It also has antitussive and sedative actions, the action being suspected to be central in nature.|
||IL Receptor | TNF-α | NF-kB | p65 | p38MAPK | ERK | JNK | IkB | IKK|
|Immunopharmacol Immunotoxicol. 2013 Oct;35(5):567-72. |
|Peimine impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-κB and MAPK in LPS-induced RAW264.7 macrophages.[Pubmed: 23944357]|
|In the previous study, we found that Peimine has good anti-inflammatory effects in vivo. However, the anti-inflammatory mechanism of Peimine remains unclear. We, therefore, assessed the effects of Peimine on inflammatory cytokines in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages.
METHODS AND RESULTS:
We found that Peimine (0-25 mg/L) significantly inhibited tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β, and increased IL-10 production. Furthermore, Peimine significantly inhibited the phosphorylation of p38, ERK and c-jun N-terminal kinase (JNK) as well as decreased p65 and IκB.
The present results indicate that Peimine inhibits the production of inflammatory cytokines induced by LPS through blocking MAPKs and NF-κB signaling pathways.
|Pharmazie. 2011 Sep;66(9):684-9. |
|Comparative pharmacokinetic studies of peimine and peiminine in rat plasma by LC-MS-MS after oral administration of Fritillaria thunbergii Miq. and Fritillaria thunbergii Miq. - Glycyrrhiza uralensis Fisch. couple extract.[Pubmed: 22026124]|
METHODS AND RESULTS:
A sensitive LC-MS-MS method has been successfully applied to pharmacokinetic study of Peimine and peiminine in rat plasma after oral administration of Fritillaria thunbergii Miq. exact and Fritillaria thunbergii Miq. - Glycyrrhiza uralensis Fisch. couple extract. The results indicated that plasma profiles of Peimine and peiminine confirmed to two-compartment open model with weighting function of 1/C2 for data fitting and parameter estimation and the utilization with Glycyrrhiza uralensis Fisch. could decrease C(max) and prolong MRT(0-infinity) and t1/2 of Peimine remarkly with the bioavailability of Peimine remained practically unchanged. Meanwhile, the concentration of Peimine in rat plasma was more stable.
Nevertheless, there were no significant differences among all calculated parameters of peiminine.
|Acta Pharmaceutica Sinica, 1985, 20(4):306-8. |
|Studies on the antitussive and sedative activities of peimine and peiminine.[Reference: WebLink]|
|The antitussive and sedative activities of Peimine and peiminine, two alkaloids isolated from Fritillaria verticillata Willd var thunbergii Bak, were investigated in laboratory.
METHODS AND RESULTS:
The EDT_(50) (the time needed to make 50% mice cough) was prolonged to 130% of the control when Peimine or peiminine 4 mg/kg was administered orally to mice induced to cough by atomized ammonium hydroxide. A 45% inhibition rate of cough amplitude was observed in anesthetized guinea pig induced to cough by stimulation of the mucosa at the tracheal bifurcation with a bristle after a sc injection of Peimine or peiminine 4 mg/kg. Peak action appeared 30～60 minutes after the injection. In cats, induced to cough by electrical stimulation at the central stump of the superior laryngeal nerve, both the incidence and amplitude of cough reflex were inhibited by sc injection of 4 mg/kg of Peimine or peiminine. The action lasted for an hour or so.The spontaneous activities of mice were significantly decreased by Peimine or peiminine after sc injection of a dose of 2 mg/kg. Furthermore, the CNS stimulating action of caffeine was antagonized and the sedative action of chlorpromazine was potentiated by Peimine and peiminine in mice at the same dose level. It appears that both Peimine and peiminine have antitussive and sedative actions, the former action being suspected to be central in nature.
However, no difference of pharmacological action, either qualitatively or quantitatively, between peiminine and peiminine has thus far been demonstrated.
||The bulbus of Fritillaria thunbergii Miq.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi: 10.1016/j.phymed.2017.12.030.PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.