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    Salvianolic acid D
    Information
    CAS No. 142998-47-8 Price
    Catalog No.CFN90223Purity>=98%
    Molecular Weight492.44Type of CompoundPhenylpropanoids
    FormulaC20H18O10Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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  • Biological Activity
    Description: Salvianolic acid and notoginseng triterpenes can promote EA-hy926 and expression of protein, have protective effects on angiogenesis in EA-hy926 cells in vitro.
    In vivo:
    Acta Pharmaceutica Sinica BVolume 5, Issue 3, May 2015, Pages 246–253
    Pharmacokinetic study of salvianolic acid D after oral and intravenous administration in rats[Reference: WebLink]

    METHODS AND RESULTS:
    A sensitive, specific and rapid LC-MS method was developed and validated for the determination of Salvianolic acid D (SalD) in rat plasma. This method used a single quadrupole mass spectrometer with an electrospray ionization (ESI) source. A single ion monitoring scanning (SIM) mode was employed. It showed good linearity over the concentration range from 3.3 to 666.7 ng/mL for the determination of Salvianolic acid D. The R.S.D.% of intra-day and inter-day precision values were no more than 7.69%, and the accuracy was within 91%−104% at all quality control levels.
    CONCLUSIONS:
    This LC-MS method was applied to the pharmacokinetic study of Salvianolic acid D in rats. A two-compartmental model analysis was employed. The bioavailability of Salvianolic acid D was calculated to be 4.159%±0.517%.
    Salvianolic acid D Description
    Source: The roots of Salvia miltiorrhiza Bge.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0307 mL 10.1535 mL 20.307 mL 40.6141 mL 50.7676 mL
    5 mM 0.4061 mL 2.0307 mL 4.0614 mL 8.1228 mL 10.1535 mL
    10 mM 0.2031 mL 1.0154 mL 2.0307 mL 4.0614 mL 5.0768 mL
    50 mM 0.0406 mL 0.2031 mL 0.4061 mL 0.8123 mL 1.0154 mL
    100 mM 0.0203 mL 0.1015 mL 0.2031 mL 0.4061 mL 0.5077 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    《China Pharmacy》 2012-08
    Isolation and Identification of Salvianolic Acid D and Simultaneous Determination of 4 Salvianolic Acids in Danshen Infusion[Reference: WebLink]
    To establish the method for the isolation and identification of Salvianolic acid D and simultaneous determination of tanshinol,protocatechuic aldehyde,Salvianolic acid D and B in Danshen infusion.
    METHODS AND RESULTS:
    RP-HPLC method was adopted for isolation and content determination.The determination was performed on Kromasil C18 column with mobile phase consisted of acetonitrile-1% glacial acetic acid at the flow rate of 1.0 mL·min-1.The injection volume was 10 μL and column temperature was 30 ℃.The detection wavelength was set at 281 nm. Salvianolic acid D had been succeddfully isolated and indentified.The linearities of tanshinol,protocatechuic aldehyde,Salvianolic acid D,salvianolic acid B were 60.9~975.0,8.7~139.0,11.0~175.8,2.7~43.2 μg·mL-1.The average recoveries rate were 99.1%,100.2%,98.3%,100.4%,102.5%,101.1%,101.4%,97.0%,102.1%,100.6%,99.2%,101.3%,and the RSDs were 0.94%,0.97%,2.78%,1.07%.
    CONCLUSIONS:
    The method is simple,rapid and specific.It may be suitable for the quality control of Danshen infusion.