ChemFaces is a professional high-purity natural products manufacturer.
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2. Pharmacological research
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More articles cited ChemFaces products.
J. of Food Composition & Analysis2017Anal Bioanal Chem.2018 Feb;Universidade Estadual Paulista2017;J Nat Med.2017 AprThe Japan Society for Analy. Chem.2017 Nov. 8;
Biol Pharm Bull. 2018;41(1):65-72.Int J Mol Sci.2015 Aug 7;16(8):18396-411.?Univ. of Limpopo2016Invest New Drugs. 2017 Apr;Sci Rep. 2017 Apr 11;
Arch Biochem Biophys. 2018 Jan 15;Journal of Medicinal Plant Research.2013 Nov 7Food Chemistry.2015 Feb.7.Arch Toxicol. 2017 Mar 20.
Our products had been exported to the following research institutions and universities, And still growing.
Funda??o Universitária de Desen... (Brazil)University of Eastern Finland (Finland)National Chung Hsing University (Taiwan)Cornell University (USA)
Monash University Malaysia (Malaysia)Tokyo Woman's Christian University (Japan)Pennsylvania State University (USA)Korea Food Research Institute(KF... (Korea)
Universite Libre de Bruxelles (Belgium)Guangzhou Institutes of Biomedic... (China)Charles Sturt University (Denmark)
||Sec-O-glucosylhamaudol has anti-inflammatory effect through regulation of p38 Mitogen-Activated Protein Kinase in Lipopolysaccharide-stimulated RAW264.7 cell line. Intrathecal sec-O-glucosylhamaudol has a very strong antinociceptive effect in the formalin test and it seems the effect is related to an opioid receptor.
||p38MAPK | NF-kB|
|2014 International Symposium and Annual Meeting, 2014.10, 338-338. |
|Anti-Inflammatory Effect of Sec-O-glucosylhamaudol from Ledebouriella seseloides through Regulation of p38 Mitogen-Activated Protein Kinase in Lipopolysaccharide-Stimulated RAW264.7 Cell Line[Reference: WebLink]|
|Anti-Inflammatory Effect of Sec-O-Glucosylhamaudol from Ledebouriella seseloides through Regulation of p38 Mitogen-Activated Protein Kinase in Lipopolysaccharide-Stimulated RAW264.7 Cell Line.|
|PLoS One. 2014 Sep 8;9(9):e107279. |
|Screening active components from Yu-ping-feng-san for regulating initiative key factors in allergic sensitization.[Pubmed: 25198676]|
|Yu-ping-feng-san (YPFS) is a Chinese medical formula that is used clinically for allergic diseases and characterized by reducing allergy relapse. Our previous studies demonstrated that YPFS efficiently inhibited T helper 2 cytokines in allergic inflammation. The underlying mechanisms of action of YPFS and its effective components remain unclear.
METHODS AND RESULTS:
In this study, it was shown that YPFS significantly inhibited production of thymic stromal lymphopoietin (TSLP), an epithelial cell-derived initiative factor in allergic inflammation, in vitro and in vivo. A method of human bronchial epithelial cell (16HBE) binding combined with HPLC-MS (named 16HBE-HPLC-MS) was established to explore potential active components of YPFS. The following five components bound to 16HBE cells: calycosin-7-glucoside, ononin, claycosin, Sec-O-Glucosylhamaudol and formononetin. Serum from YPFS-treated mice was analyzed and three major components were detected claycosin, formononetin and cimifugin. Among these, claycosin and formononetin were detected by 16HBE-HPLC-MS and in the serum of YPFS-treated mice. Claycosin and formononetin decreased the level of TSLP markedly at the initial stage of allergic inflammation in vivo. Nuclear factor (NF)-κB, a key transcription factor in TSLP production, was also inhibited by claycosin and formononetin, either in terms of transcriptional activation or its nuclear translocation in vitro. Allergic inflammation was reduced by claycosin and formononetin when they are administered only at the initial stage in a murine model of atopic contact dermatitis.
Thus, epithelial cell binding combined with HPLC-MS is a valid method for screening active components from complex mixtures of Chinese medicine. It was demonstrated that the compounds screened from YPFS significantly attenuated allergic inflammation probably by reducing TSLP production via regulating NF-κB activation.
|Korean J Pain. 2017 Apr; 30(2): 98–103. |
|Antinociceptive effect of intrathecal sec-O-glucosylhamaudol on the formalin-induced pain in rats.[Pubmed: 28416993]|
|The root of Peucedanum japonicum Thunb., a perennial herb found in Japan, the Philippines, China, and Korea, is used as an analgesic. In a previous study, Sec-O-Glucosylhamaudol (SOG) showed an analgesic effect.
METHODS AND RESULTS:
This study was performed to examine the antinociceptive effect of intrathecal SOG in the formalin test. Results:Intrathecal SOG showed a significant reduction of the flinching responses at both phases in a dose-dependent manner. Significant effects were showed from the dose of 30 μg and maximum effects were achieved at a dose of 100 μg in both phases. The ED50 value (95% confidence intervals) of intrathecal SOG was 30.3 (25.8–35.5) μg during phase 1, and 48.0 (41.4–55.7) during phase 2. The antinociceptive effects of SOG (100 μg) were significantly reverted at both phases of the formalin test by naloxone.
Conclusions:These results demonstrate that intrathecal SOG has a very strong antinociceptive effect in the formalin test and it seems the effect is related to an opioid receptor.
||The herbs of Ledebouriella seseloides.
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi: 10.1016/j.phymed.2017.12.030.PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jan 1;944:35-8. |
|Determination of sec-O-glucosylhamaudol in rat plasma by gradient elution liquid chromatography-mass spectrometry.[Pubmed: 24291717]|
|Sec-O-Glucosylhamaudol is one of the major bioactive compounds of the Saposhnikoviae Radix.
METHODS AND RESULTS:
A simple and selective liquid chromatography-mass spectrometry (LC-MS) method for determination of Sec-O-Glucosylhamaudol in rat plasma was developed. After addition of carbamazepine as internal standard (IS), protein precipitation with acetonitrile-methanol (9:1, v/v) was used as sample preparation. Chromatographic separation was achieved on a Zorbax SB-C18 (2.1mm×150mm, 5μm) column with acetonitrile-0.1% formic acid in water as mobile phase with gradient elution. Electrospray ionization (ESI) source was applied and operated in positive ion mode; selective ion monitoring (SIM) mode was used for quantification using target fragment ions m/z 439 for Sec-O-Glucosylhamaudol and m/z 237 for the IS. Calibration plots were linear over the range of 50-8000ng/mL for Sec-O-Glucosylhamaudol in rat plasma. Mean recovery of Sec-O-Glucosylhamaudol in plasma was in the range of 74.8-83.7%. Intra-day and inter-day precision were both <15%.
This method was successfully applied in pharmacokinetic study after intravenous administration of 2.5mg/kg Sec-O-Glucosylhamaudol in rats.