Science | Nature | Cell | View More
Natural Products
Sodium Dichloroacetate
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Sodium Dichloroacetate
Price: $30 / 20mg
CAS No.: 2156-56-1
Catalog No.: CFN90889
Molecular Formula: C2HCl2NaO2
Molecular Weight: 150.9 g/mol
Purity: >=98%
Type of Compound: Miscellaneous
Physical Desc.: Powder
Source: The peels of Punica granatum L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $7.0 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Otago (New Zealand)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Universidade Federal de Santa C... (Brazil)
  • Hamdard University (India)
  • Medical University of South Car... (USA)
  • Complutense University of Madrid (Spain)
  • University of Maryland (USA)
  • Universidade do Porto (Portugal)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Agricultural Research Organizat... (Israel)
  • Istanbul University (Turkey)
  • More...
Package
Featured Products
Peonidin-3-O-arabinoside chloride

Catalog No: CFN92047
CAS No: 524943-91-7
Price: $318/5mg
Asiatic acid

Catalog No: CFN98688
CAS No: 464-92-6
Price: $40/20mg
Ophiopogonin D

Catalog No: CFN98156
CAS No: 41753-55-3
Price: $248/20mg
Biatractylolide

Catalog No: CFN95205
CAS No: 182426-37-5
Price: $268/10mg
alpha-Mangostin

Catalog No: CFN97050
CAS No: 6147-11-1
Price: $40/20mg
8-Acetoxypinoresinol

Catalog No: CFN00449
CAS No: 81426-14-4
Price: $ / mg
Beta-Carotene

Catalog No: CFN98117
CAS No: 7235-40-7
Price: $40/20mg
Isorhyncophylline

Catalog No: CFN92553
CAS No: 6859-01-4
Price: $158/20mg
Matairesinol

Catalog No: CFN98983
CAS No: 580-72-3
Price: $318/10mg
Kukoamine B

Catalog No: CFN93216
CAS No: 164991-67-7
Price: $268/10mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Sodium dichloroacetate is a drug with potential for treating patients with stroke and head injury. Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3; it is cytoprotective to some colorectal cancer cells under hypoxic conditions.
Targets: p53 | Mdm2 | p21
In vitro:
Cancer Lett. 2010 Nov 1;297(1):75-83.
Sodium dichloroacetate (DCA) reduces apoptosis in colorectal tumor hypoxia.[Pubmed: 20537792 ]

METHODS AND RESULTS:
We examined the effect of hypoxia on apoptosis of human colorectal cancer (CRC) cells in vitro and in vivo. All cell lines tested were susceptible to hypoxia-induced apoptosis. Sodium Dichloroacetate (DCA) treatment caused significant apoptosis under normoxia in SW480 and Caco-2 cells, but these cells displayed decreased apoptosis when treated with DCA combined with hypoxia, possibly through HIF-1alpha dependent pathways. DCA treatment also induced significantly increased growth of SW480 tumor xenografts, and a decrease in TUNEL positive nuclei in hypoxic but not normoxic regions of treated tumors.
CONCLUSIONS:
Thus DCA is cytoprotective to some CRC cells under hypoxic conditions, highlighting the need for further investigation before DCA can be used as a reliable apoptosis-inducing agent in cancer therapy.
Oncotarget. 2014 Jun; 5(12): 4347–4360.
Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3[Pubmed: 24962518 ]

METHODS AND RESULTS:
The anti-leukemic activity of the mitochondria-targeting small molecule Sodium Dichloroacetate (DCA), used alone and in association with the small molecule inhibitor of the p53/MDM2 interaction Nutlin-3, was analyzed in primary B-chronic lymphocytic leukemia (B-CLL) samples (n=22), normal peripheral blood cells (n=10) and in p53wild-type EHEB, JVM-2, JVM-3 B lymphoblastoid cell lines. DCA exhibited a dose-dependent anti-leukemic activity in both primary B-CLL and B leukemic cell lines with a functional p53 status and showed a synergistic cytotoxic activity when used in combination with Nutlin-3. At the molecular level, DCA positively regulated p53 activity, as documented by post-transcriptional modifications of p53 protein, and synergized with Nutlin-3 in increasing the expression of the p53-target genes MDM2, PUMA, TIGAR and in particular p21. The potential role of p21 in mediating the DCA+Nutlin-3 anti-leukemic activity was underscored in knocking-down experiments. Indeed, transfection of leukemic cells with p21 siRNAs significantly decreased the DCA+Nutlin-3-induced cytotoxicity.
CONCLUSIONS:
Taken together, our data emphasize that DCA is a molecule that merits to be further evaluated as a chemotherapeutic agent for B-CLL, likely in combination with other therapeutic compounds.
In vivo:
Fundam Appl Toxicol. 1996 Jul;32(1):87-95.
Absence of mutagenic effects of sodium dichloroacetate.[Pubmed: 8812237]
Sodium Dichloroacetate (DCA) is a drug with potential for treating patients with stroke and head injury. Conflicting evidence has been published on the mutagenic potential of DCA.
METHODS AND RESULTS:
A series of genetic tests for mutagenicity and clastogenicity was carried out on pharmaceutical grade DCA. Four types of mutagenicity test were included, with and without metabolic activation where appropriate. These studies included: (i) Salmonella and Escherichia coli mutation (Ames) test, (ii) thymidine kinase locus forward mutation in L5178Y mouse lymphoma cells, (iii) tests for chromosomal aberrations in Chinese hamster ovary cells, and (iv) and in vivo rat bone marrow erythroid micronucleus test. In each study, there was no evidence of mutagenic activity attributable to DCA. It is possible that the present test material, of pharmaceutical grade, has fewer impurities than materials studied in previous reports.
CONCLUSIONS:
These data extend, and in some cases contradict, previous published reports on DCA.
Sodium Dichloroacetate Description
Source: The peels of Punica granatum L.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
cis-Mulberroside A

Catalog No: CFN95006
CAS No: 166734-06-1
Price: $418/10mg
Orthosiphol A

Catalog No: CFN95442
CAS No: 142741-25-1
Price: $318/5mg
4-Hydroxybenzoyl choline

Catalog No: CFN95158
CAS No: 5094-31-5
Price: $318/20mg
3''-Galloylquercitrin

Catalog No: CFN95048
CAS No: 503446-90-0
Price: $368/5mg
Symplocoside

Catalog No: CFN95552
CAS No: 76502-76-6
Price: $318/5mg
Benzyl beta-D-glucopyranoside

Catalog No: CFN95427
CAS No: 4304-12-5
Price: $318/10mg
Ganoderic acid beta

Catalog No: CFN95537
CAS No: 217476-76-1
Price: $413/5mg
Dehydrojuncusol

Catalog No: CFN95143
CAS No: 117824-04-1
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 6.6269 mL 33.1345 mL 66.2691 mL 132.5381 mL 165.6726 mL
5 mM 1.3254 mL 6.6269 mL 13.2538 mL 26.5076 mL 33.1345 mL
10 mM 0.6627 mL 3.3135 mL 6.6269 mL 13.2538 mL 16.5673 mL
50 mM 0.1325 mL 0.6627 mL 1.3254 mL 2.6508 mL 3.3135 mL
100 mM 0.0663 mL 0.3313 mL 0.6627 mL 1.3254 mL 1.6567 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Peonidin-3-O-arabinoside chloride

Catalog No: CFN92047
CAS No: 524943-91-7
Price: $318/5mg
Asiatic acid

Catalog No: CFN98688
CAS No: 464-92-6
Price: $40/20mg
Ophiopogonin D

Catalog No: CFN98156
CAS No: 41753-55-3
Price: $248/20mg
Biatractylolide

Catalog No: CFN95205
CAS No: 182426-37-5
Price: $268/10mg
alpha-Mangostin

Catalog No: CFN97050
CAS No: 6147-11-1
Price: $40/20mg
8-Acetoxypinoresinol

Catalog No: CFN00449
CAS No: 81426-14-4
Price: $ / mg
Beta-Carotene

Catalog No: CFN98117
CAS No: 7235-40-7
Price: $40/20mg
Isorhyncophylline

Catalog No: CFN92553
CAS No: 6859-01-4
Price: $158/20mg
Matairesinol

Catalog No: CFN98983
CAS No: 580-72-3
Price: $318/10mg
Kukoamine B

Catalog No: CFN93216
CAS No: 164991-67-7
Price: $268/10mg
Tags: buy Sodium Dichloroacetate | Sodium Dichloroacetate supplier | purchase Sodium Dichloroacetate | Sodium Dichloroacetate cost | Sodium Dichloroacetate manufacturer | order Sodium Dichloroacetate | Sodium Dichloroacetate distributor