• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Natural Products
    Sodium Dichloroacetate
    Information
    CAS No. 2156-56-1 Price $30 / 20mg
    Catalog No.CFN90889Purity>=98%
    Molecular Weight150.9Type of CompoundMiscellaneous
    FormulaC2HCl2NaO2Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    Our products had been exported to the following research institutions and universities, And still growing.
  • Max-Planck-Insitut (Germany)
  • Worcester Polytechnic Institute (USA)
  • University of Maryland School of... (USA)
  • University of Amsterdam (Netherlands)
  • Universidad Veracuzana (Mexico)
  • Massachusetts General Hospital (USA)
  • Seoul National University of Sci... (Korea)
  • University of Madras (India)
  • University of Perugia (Italy)
  • Martin Luther University of Hall... (Germany)
  • University of Lodz (Poland)
  • More...
  • Package
    Featured Products
    Neochamaejasmine A

    Catalog No: CFN92151
    CAS No: 90411-13-5
    Price: $418/5mg
    Dihydrokavain

    Catalog No: CFN90536
    CAS No: 587-63-3
    Price: $318/20mg
    Ginsenoside Re

    Catalog No: CFN99974
    CAS No: 52286-59-6
    Price: $40/20mg
    Isochlorogenic acid C

    Catalog No: CFN99120
    CAS No: 32451-88-0
    Price: $138/20mg
    Angustifoline

    Catalog No: CFN92233
    CAS No: 550-43-6
    Price: $490/5mg
    Biological Activity
    Description: Sodium dichloroacetate is a drug with potential for treating patients with stroke and head injury. Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3; it is cytoprotective to some colorectal cancer cells under hypoxic conditions.
    Targets: p53 | Mdm2 | p21
    In vitro:
    Cancer Lett. 2010 Nov 1;297(1):75-83.
    Sodium dichloroacetate (DCA) reduces apoptosis in colorectal tumor hypoxia.[Pubmed: 20537792 ]

    METHODS AND RESULTS:
    We examined the effect of hypoxia on apoptosis of human colorectal cancer (CRC) cells in vitro and in vivo. All cell lines tested were susceptible to hypoxia-induced apoptosis. Sodium Dichloroacetate (DCA) treatment caused significant apoptosis under normoxia in SW480 and Caco-2 cells, but these cells displayed decreased apoptosis when treated with DCA combined with hypoxia, possibly through HIF-1alpha dependent pathways. DCA treatment also induced significantly increased growth of SW480 tumor xenografts, and a decrease in TUNEL positive nuclei in hypoxic but not normoxic regions of treated tumors.
    CONCLUSIONS:
    Thus DCA is cytoprotective to some CRC cells under hypoxic conditions, highlighting the need for further investigation before DCA can be used as a reliable apoptosis-inducing agent in cancer therapy.
    Oncotarget. 2014 Jun; 5(12): 4347–4360.
    Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3[Pubmed: 24962518 ]

    METHODS AND RESULTS:
    The anti-leukemic activity of the mitochondria-targeting small molecule Sodium Dichloroacetate (DCA), used alone and in association with the small molecule inhibitor of the p53/MDM2 interaction Nutlin-3, was analyzed in primary B-chronic lymphocytic leukemia (B-CLL) samples (n=22), normal peripheral blood cells (n=10) and in p53wild-type EHEB, JVM-2, JVM-3 B lymphoblastoid cell lines. DCA exhibited a dose-dependent anti-leukemic activity in both primary B-CLL and B leukemic cell lines with a functional p53 status and showed a synergistic cytotoxic activity when used in combination with Nutlin-3. At the molecular level, DCA positively regulated p53 activity, as documented by post-transcriptional modifications of p53 protein, and synergized with Nutlin-3 in increasing the expression of the p53-target genes MDM2, PUMA, TIGAR and in particular p21. The potential role of p21 in mediating the DCA+Nutlin-3 anti-leukemic activity was underscored in knocking-down experiments. Indeed, transfection of leukemic cells with p21 siRNAs significantly decreased the DCA+Nutlin-3-induced cytotoxicity.
    CONCLUSIONS:
    Taken together, our data emphasize that DCA is a molecule that merits to be further evaluated as a chemotherapeutic agent for B-CLL, likely in combination with other therapeutic compounds.
    In vivo:
    Fundam Appl Toxicol. 1996 Jul;32(1):87-95.
    Absence of mutagenic effects of sodium dichloroacetate.[Pubmed: 8812237]
    Sodium Dichloroacetate (DCA) is a drug with potential for treating patients with stroke and head injury. Conflicting evidence has been published on the mutagenic potential of DCA.
    METHODS AND RESULTS:
    A series of genetic tests for mutagenicity and clastogenicity was carried out on pharmaceutical grade DCA. Four types of mutagenicity test were included, with and without metabolic activation where appropriate. These studies included: (i) Salmonella and Escherichia coli mutation (Ames) test, (ii) thymidine kinase locus forward mutation in L5178Y mouse lymphoma cells, (iii) tests for chromosomal aberrations in Chinese hamster ovary cells, and (iv) and in vivo rat bone marrow erythroid micronucleus test. In each study, there was no evidence of mutagenic activity attributable to DCA. It is possible that the present test material, of pharmaceutical grade, has fewer impurities than materials studied in previous reports.
    CONCLUSIONS:
    These data extend, and in some cases contradict, previous published reports on DCA.
    Sodium Dichloroacetate Description
    Source: The peels of Punica granatum L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Recent ChemFaces New Products and Compounds
    Ginsenoside F1

    Catalog No: CFN99754
    CAS No: 53963-43-2
    Price: $148/20mg
    2'-Rhamnoechinacoside

    Catalog No: CFN95035
    CAS No: 1422390-59-7
    Price: $368/10mg
    Isochlorogenic acid A

    Catalog No: CFN99118
    CAS No: 2450-53-5
    Price: $108/20mg
    Oroxylin A

    Catalog No: CFN98540
    CAS No: 480-11-5
    Price: $138/20mg
    Isokaempferide

    Catalog No: CFN93002
    CAS No: 1592-70-7
    Price: $368/5mg
    Trifolirhizin

    Catalog No: CFN97160
    CAS No: 6807-83-6
    Price: $128/20mg
    Syringaresinol

    Catalog No: CFN92060
    CAS No: 487-35-4
    Price: $268/5mg
    Irigenin

    Catalog No: CFN93276
    CAS No: 548-76-5
    Price: $238/20mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    Scientific Reports 2017 Dec 11;7(1):17332.
    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

    Molecules. 2017 Oct 27;22(11). pii: E1829.
    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

    PMID: 28857247

    Phytomedicine. 2018 Feb 1;40:37-47.
    doi: 10.1016/j.phymed.2017.12.030.

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.6269 mL 33.1345 mL 66.2691 mL 132.5381 mL 165.6726 mL
    5 mM 1.3254 mL 6.6269 mL 13.2538 mL 26.5076 mL 33.1345 mL
    10 mM 0.6627 mL 3.3135 mL 6.6269 mL 13.2538 mL 16.5673 mL
    50 mM 0.1325 mL 0.6627 mL 1.3254 mL 2.6508 mL 3.3135 mL
    100 mM 0.0663 mL 0.3313 mL 0.6627 mL 1.3254 mL 1.6567 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.