ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $32.2 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Molecules.2015, 20(11):20014-30Acta Physiologiae Plantarum...2015...J Pharm Biomed Anal.2016, 129:50-59Nat Prod Commun.2017, 12(5):771-778Int J Mol Sci.2017, 18(12)J Ethnopharmacol.2017, 209:305-316Molecules.2017, 22(11)Food Chem.2017, 221:1135-1144
Journal of Life Science2017, 233-240Front Aging Neurosci.2018, 10:269J Pharm Biomed Anal.2018, 151:32-41Nat Prod Sci.2018, 24(3):206The Japan Society for Analytical ...2018...Clin Transl Oncol.2019, 10.1007J Chromatogr B Analyt Technol Bio...2019...Mol Microbiol.2019, 112(1):317-332
Nutrients.2019, 12(1)Molecules.2019, 24(6):E1177Journal of Food Hygiene and Safet...2019...Chem Pharm Bull (Tokyo)....2019...Neurochem Int.2020, 133:104629Food Chem Toxicol.2020, 135:110863Antioxidants (Basel).2020, 9(2):E99
Our products had been exported to the following research institutions and universities, And still growing.
University of Canterbury (New Zealand)Cancer Research Initatives Foun... (Malaysia)Medizinische Universit?t Wien (Austria)Charles University in Prague (Czech Republic)
Universite Libre de Bruxelles (Belgium)University of Zurich (Switzerland)University of Bordeaux (France)Medical University of Gdansk (Poland)
VIB Department of Plant Systems... (Belgium)Indian Institute of Science (India)Kyung Hee University (Korea)
Related Screening Libraries
||Solanesol can effectively scavenge lipid radicals to block lipid peroxidation, and inhibit effects on tyrosinase; it also can protect ethanol-induced L02 cell damage, which might be attributed to the activation of HO-1 and Hsp70.|
||HSP (e.g. HSP90) | HO-1 | Caspase | PARP|
|Toxicol In Vitro. 2015 Apr;29(3):600-8. |
|Solanesol protects human hepatic L02 cells from ethanol-induced oxidative injury via upregulation of HO-1 and Hsp70.[Pubmed: 25645596]|
METHODS AND RESULTS:
In present study, we showed that the mRNA and protein levels of HO-1 and Hsp70 in Solanesol-treated L02 cells were significantly increased. The induction of the HO-1 by Solanesol is majorly achieved via enhancing the nuclear translocation and transactivity of Nrf2 through enhancement of Hsp90-Keap1 interaction, while Solanesol-elevated Hsp70 is related with promoting the nuclear translocation of HSF1 through the involvement of chaperones interaction. Furthermore, the induction of HO-1 and Hsp70 by Solanesol could protect against ethanol-induced liver injury, including significantly suppressing the elevation of the activities of LDH and AST, attenuating ethanol-induced increase of the MDA, ROS level and decrease of the GSH level. Moreover, Solanesol also suppressed ethanol-induced apoptosis of L02 cells by inhibition of nuclear morphological damage, procaspase 3 and cleavage of caspase 3 and PARP, suggesting Solanesol may be beneficial against ALD. Solanesol also promoted tBHQ-mediated protective effects. However, treatment cells with SnPP or PES markedly abrogated the protective effects of Solanesol on ethanol-induced cell injury.
These results strongly suggested that Solanesol could protect ethanol-induced L02 cell damage, which might be attributed to the activation of HO-1 and Hsp70.
|Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2014 Aug;31(4):833-6, 841. |
|Antioxidant function of solanesol and its inhibitory effect on tyrosinase[Pubmed: 25464797]|
|The present paper intends to discuss the antioxidant and tyrosinase inhibition effect of Solanesol from three aspects of ultraviolet radiation and free radical scavenging. |
METHODS AND RESULTS:
The paper makes a survey on diurnal variation rule of the minimum ultraviolet transmittance and ultraviolet transmittance of Solanesol, hydroxyl (OH) free radical scavenging method of Smirnoff reaction system model, superoxide anion O2- free radical scavenging method of pyrogallol autoxidation, and the inhibitory effect of Solanesol on tyrosinase activity by enzyme kinetic method. The experiment results showed that Solanesol could effectively scavenge lipid radicals to block lipid peroxidation, and inhibit effects on tyrosinase.
METHODS AND RESULTS:
Solanesol is a natural extract which could be used to prevent senile atrophy of human skin and senile plaque.
||The herbs of Nicotiana tabacum L.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.