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    Solanesol
    Information
    CAS No. 13190-97-1 Price $30 / 20mg
    Catalog No.CFN90454Purity>=98%
    Molecular Weight631.07Type of CompoundMiscellaneous
    FormulaC45H74OPhysical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $32.2 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
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  • Biological Activity
    Description: Solanesol can effectively scavenge lipid radicals to block lipid peroxidation, and inhibit effects on tyrosinase; it also can protect ethanol-induced L02 cell damage, which might be attributed to the activation of HO-1 and Hsp70.
    Targets: HSP (e.g. HSP90) | HO-1 | Caspase | PARP
    In vitro:
    Toxicol In Vitro. 2015 Apr;29(3):600-8.
    Solanesol protects human hepatic L02 cells from ethanol-induced oxidative injury via upregulation of HO-1 and Hsp70.[Pubmed: 25645596]

    METHODS AND RESULTS:
    In present study, we showed that the mRNA and protein levels of HO-1 and Hsp70 in Solanesol-treated L02 cells were significantly increased. The induction of the HO-1 by Solanesol is majorly achieved via enhancing the nuclear translocation and transactivity of Nrf2 through enhancement of Hsp90-Keap1 interaction, while Solanesol-elevated Hsp70 is related with promoting the nuclear translocation of HSF1 through the involvement of chaperones interaction. Furthermore, the induction of HO-1 and Hsp70 by Solanesol could protect against ethanol-induced liver injury, including significantly suppressing the elevation of the activities of LDH and AST, attenuating ethanol-induced increase of the MDA, ROS level and decrease of the GSH level. Moreover, Solanesol also suppressed ethanol-induced apoptosis of L02 cells by inhibition of nuclear morphological damage, procaspase 3 and cleavage of caspase 3 and PARP, suggesting Solanesol may be beneficial against ALD. Solanesol also promoted tBHQ-mediated protective effects. However, treatment cells with SnPP or PES markedly abrogated the protective effects of Solanesol on ethanol-induced cell injury.
    CONCLUSIONS:
    These results strongly suggested that Solanesol could protect ethanol-induced L02 cell damage, which might be attributed to the activation of HO-1 and Hsp70.
    Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2014 Aug;31(4):833-6, 841.
    Antioxidant function of solanesol and its inhibitory effect on tyrosinase[Pubmed: 25464797]
    The present paper intends to discuss the antioxidant and tyrosinase inhibition effect of Solanesol from three aspects of ultraviolet radiation and free radical scavenging.
    METHODS AND RESULTS:
    The paper makes a survey on diurnal variation rule of the minimum ultraviolet transmittance and ultraviolet transmittance of Solanesol, hydroxyl (OH) free radical scavenging method of Smirnoff reaction system model, superoxide anion O2- free radical scavenging method of pyrogallol autoxidation, and the inhibitory effect of Solanesol on tyrosinase activity by enzyme kinetic method. The experiment results showed that Solanesol could effectively scavenge lipid radicals to block lipid peroxidation, and inhibit effects on tyrosinase.
    METHODS AND RESULTS:
    Solanesol is a natural extract which could be used to prevent senile atrophy of human skin and senile plaque.
    Solanesol Description
    Source: The herbs of Nicotiana tabacum L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5846 mL 7.9231 mL 15.8461 mL 31.6922 mL 39.6153 mL
    5 mM 0.3169 mL 1.5846 mL 3.1692 mL 6.3384 mL 7.9231 mL
    10 mM 0.1585 mL 0.7923 mL 1.5846 mL 3.1692 mL 3.9615 mL
    50 mM 0.0317 mL 0.1585 mL 0.3169 mL 0.6338 mL 0.7923 mL
    100 mM 0.0158 mL 0.0792 mL 0.1585 mL 0.3169 mL 0.3962 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.