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    Stigmastane-3,6-diol
    Information
    CAS No. 112244-29-8 Price
    Catalog No.CFN99220Purity>=98%
    Molecular Weight432.7 Type of CompoundSteroids
    FormulaC29H52O2Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Stigmastane-3 beta, 6 alpha-diol and stigmastane-3 beta, 6 beta-diol possess marked inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, the 50% inhibitory dose is 0.5--1.0 mg/ear.
    In vivo:
    Biol Pharm Bull. 1995 Nov;18(11):1617-9.
    Inhibitory effect of some oxygenated stigmastane-type sterols on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice.[Pubmed: 8593493]

    METHODS AND RESULTS:
    The oxygenated stigmastane-type sterols stigmastane-3 beta, 6 alpha-diol(Stigmastane-3,6-diol), stigmastane-3 beta, 6 beta-diol, 7 alpha-hydroxysitosterol and its diacetyl derivative, 7 beta-hydroxysitosterol and its diacetyl derivative, 7-oxositosterol, 4 beta-hydroxysitosterol, and stigmast-4-ene-3 beta, 6 beta-diol were evaluated with respect to their anti-inflammatory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice.
    CONCLUSIONS:
    All of the sterols, with the exception of 7 alpha-hydroxysitosterol and its diacetyl derivative, were found to possess marked inhibitory activity. The 50% inhibitory dose of these compounds for TPA-inflammation (1 microgram) was 0.5--1.0 mg/ear.
    Stigmastane-3,6-diol Description
    Source: The fruits of Trichosanthes kirilowii
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

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    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3111 mL 11.5554 mL 23.1107 mL 46.2214 mL 57.7768 mL
    5 mM 0.4622 mL 2.3111 mL 4.6221 mL 9.2443 mL 11.5554 mL
    10 mM 0.2311 mL 1.1555 mL 2.3111 mL 4.6221 mL 5.7777 mL
    50 mM 0.0462 mL 0.2311 mL 0.4622 mL 0.9244 mL 1.1555 mL
    100 mM 0.0231 mL 0.1156 mL 0.2311 mL 0.4622 mL 0.5778 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Planta Med 2008; 74 - P-101
    Chemical Studies of Casearia sylvestris Swartz[Reference: WebLink]

    METHODS AND RESULTS:
    In the present report, the isolation and structure elucidation of two new highly oxygenated clerodane diterpenes casearins U and V (1 and 2) and two new ent -kauranoid diterpene glycosides sylvestriside A and B (3 and 4) were described from C. sylvestris (see Fig. 1), together with 3 known diterpenes, namely, (−)-hardwickic acid (5), (−)-patagonic acid (6) and ent-3β, 18-dihydroxykaur-16-ene (7), as well as 11 other known compounds, namely, spathulenol (8), 7, 8-dihydrovomifoliol (blumenol B 9), N-methyl-trans-4-hydroxy-L-proline (10), Cinnamic acid (11), Soyacerebroside I (12), methypheophorbides (13), pheophorbide a (14), chlorophyll (15), β-sitosterol (16), Stigmastane-3,6-diol (17), daucosterol (18), β-D-glucopyranoside, (3β)-stigmast-5-en-3-yl, 6-nonadecanoate (19).