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    CAS No. 63238-66-4 Price $288 / 20mg
    Catalog No.CFN90688Purity>=98%
    Molecular Weight573.29Type of CompoundAlkaloids
    FormulaC31H43NO9Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Benzoylhypacoitine might be the principal active components which affect mitochondrial growth by Fuzi and its processed products.
    Targets: Immunology & Inflammation related
    In vitro:
    《Pharmacology and Clinics of Chinese Materia Medica》 2013-05
    The effect of the active parts and components of Mahuangfuzixixin Decoction on RAW 264.7 cells[Reference: WebLink]
    To research the effect of the active parts and components of Mahuang-Fuzi-Xixin Decoction on RAW 264. 7 cells which was induced by lipopolysaccharide.
    As the cells was deduced by lipopolysaccharide( 1μg / ml),the non-toxic concentrations of the active parts and components of Mahuang-Fuzi-Xixin Decoction were selected to be done,the change of viability of the cells was observed by MTT method. The total alkaloids of Mahuang( 100μg / L),volatile oil of Xixin( 2. 2μl / L) and ephedrine,methylephedrine, pseudoephedrine,Benzoylhypacoitine,benzoylaconine at the concentration of 10μg / L to 100μg / L could inhibited the proliferation of RAW 264. 7 induced by lipopolysaccharide,compared with controlled group,the differences was siginificant( P 0. 05). The others had no this effect.
    The effects were different of the active parts and components of Mahuang-Fuzi-Xixin Decoction on RAW 264. 7 cells.
    In vivo:
    《Beijing Journal of Traditional Chinese Medicine》 2014-05
    Safety of compound formula of fuzi for the treatment of arthralgia with cold-damp obstruction type[Reference: WebLink]
    To explore the safety of compound formula of fuzi for the treatment of arthralgia with cold-damp obstruction type,so as to provide references for its safe clinical application.
    According to different TCM syndrome scores,56 cases were treated with TCM water decoction with different doses of fuzi. At predetermined time points,blood was collected to prepare the blood samples. Pharmacokinetic parameters in each sample were test to perform safety analysis. Only monoester-type Benzoylaconine( BAC),Benzoylmesaconine( BMA),Benzoylhypacoitine( BHA) and diesters-type hypaconitine( HA) were tested positive,which all had lower blood concentration than poison dosage of fuzi. The two compartment model was the best compartment model to fit the pharmacokinetic parameters,which was different from the results of animal experiment.
    The dosages used in this study are safe in clinic; the differences of each alkaloid metabolism are significant,which may be associated with other unknown factors.
    Benzoylhypacoitine Description
    Source: The roots of Aconitum carmichaeli Debx.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7443 mL 8.7216 mL 17.4432 mL 34.8864 mL 43.6079 mL
    5 mM 0.3489 mL 1.7443 mL 3.4886 mL 6.9773 mL 8.7216 mL
    10 mM 0.1744 mL 0.8722 mL 1.7443 mL 3.4886 mL 4.3608 mL
    50 mM 0.0349 mL 0.1744 mL 0.3489 mL 0.6977 mL 0.8722 mL
    100 mM 0.0174 mL 0.0872 mL 0.1744 mL 0.3489 mL 0.4361 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Structure Identification:
    Journal of ethnopharmacology (Impact Factor: 2.94). 03/2014; 153(3).
    Spectrum-effect relationships between UPLC fingerprints and bioactivities of crude secondary roots of Aconitum carmichaeli Debeaux (Fuzi) and its three processed products on mitochondrial growth coupled with canonical correlation analysis.[Reference: WebLink]
    Ethnopharmacological relevance: The crude secondary roots of Aconitum carmichaelii Debeaux (Fuzi), together with its processed products, including Yanfuzi, Heishunpian and Paofupian, are commonly applied in clinic using for thousands of years, such as collapse, syncope, rheumatic fever, painful joints and various tumors.
    To explore the different effects of Fuzi and its processed products on energy metabolism, with mitochondria as the model with the aim of guiding the clinical use of Fuzi and its products. fingerprints of Fuzi, Yanfuzi, Heishunpian and Paofupian were established by Ultra-high Performance Liquid Chromatography (UPLC) and effects of Fuzi and its processed products on rat's liver׳s mitochondrial metabolism were studied by microcalorimetry. Spectrum-effect relationships between UPLC fingerprints and energy metabolism of mitochondria were investigated using canonical correlation analysis (CCA). Because of their inherent differences in chemical compositions, the main activities of energy metabolism of mitochondria were different among Fuzi and its processed products. The potential bioactivity sequence of the tested products was Fuzi>Heishunpian>Paofupian>Yanfuzi. RESULTS of CCA showed that compounds mesaconitine, benzoylaconitine, and Benzoylhypacoitine might be the principal active components.
    Altogether, this work provides a general model of combination of UPLC and microcalorimetry to study the spectrum-effect relationships of Fuzi and its processed products which can offer some references for detecting principal components of traditional Chinese medicine on bioactivity to mitochondrial growth.