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    Stigmastane-3,6-dione
    Information
    CAS No. 22149-69-5 Price
    Catalog No.CFN98206Purity>=98%
    Molecular Weight428.7 Type of CompoundSteroids
    FormulaC29H48O2Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Stigmastane-3,6-dione has anti-inflammatory activity. 5 alpha-Stigmastane-3,6-dione shows antifeedant activity against bell weevils.
    Targets: Immunology & Inflammation related
    In vivo:
    Planta Med., 2008, 74(9):983-4.
    Three anti-inflammatory stigmastane steroids from Alchornea floribunda leaves[Reference: WebLink]
    The anti-inflammatory activities of these compounds were evaluated using in vitro and in vivo animal models.
    METHODS AND RESULTS:
    The compounds, 1, 2 and 3 at 5mg/ear inhibited xylene – induced ear edema in mice, with edema inhibitions of 59.9, 51.5 and 51.54% respectively. At 20mg/kg (ip), all the compounds significantly (p<0.05) inhibited acute inflammation induced by subplanta injection of undiluted egg albumen in rats' paw. Compound 1 exhibited a higher anti-inflammatory effect (% edema inhibition=50. 0) than prednisolone (% edema inhibition=48.0) at 3h. 1 and 3 at concentrations of 50 and 100μg/ml significantly (p<0.05) stabilized heat-induced haemolysis of human erythrocytes in vitro, but have no effect on hypotonicity-induced haemolysis. Spectral analysis elucidated the compounds as Stigmastane-3,6-dione (1), stigmastane-22-ene-3,6-dione (2) and 3-hydroxystigmastane-22-ene (3).
    CONCLUSIONS:
    These compounds may, in part, account for the anti-inflammatory effect of Alchornea floribunda leaves.
    Stigmastane-3,6-dione Description
    Source: The roots of Piper nigrum
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

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    doi: 10.1038/s41598-017-17427-6.

    PMID: 29230013

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    doi: 10.3390/molecules22111829.

    PMID: 29077044

    J Cell Biochem. 2018 Feb;119(2):2231-2239.
    doi: 10.1002/jcb.26385.

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    doi:10.1016/j.phymed.2017.12.030

    PMID: 29496173
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3326 mL 11.6632 mL 23.3263 mL 46.6527 mL 58.3158 mL
    5 mM 0.4665 mL 2.3326 mL 4.6653 mL 9.3305 mL 11.6632 mL
    10 mM 0.2333 mL 1.1663 mL 2.3326 mL 4.6653 mL 5.8316 mL
    50 mM 0.0467 mL 0.2333 mL 0.4665 mL 0.9331 mL 1.1663 mL
    100 mM 0.0233 mL 0.1166 mL 0.2333 mL 0.4665 mL 0.5832 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Animal Research:
    J. Agric.Food Chem.,1994, 42(7):1561-2.
    Boll weevil antifeedants from Eleocharis dulcis Trin.[Reference: WebLink]

    METHODS AND RESULTS:
    Six compounds were isolated from the CH2Cl2 extract of eleocharis dulcis Trin. They are hexacosanoic acid, 5 alpha-Stigmastane-3,6-dione, beta-sitosterol, stigmasterol, betulin, and tricin.
    CONCLUSIONS:
    5 alpha-Stigmastane-3,6-dione, betulin, and tricin showed antifeedant activity against boll weevils.
    Structure Identification:
    Nat Prod Res. 2013 Aug;27(15):1404-7.
    Triterpenoid profile of flower and leaf cuticular waxes of heather Calluna vulgaris.[Pubmed: 23148482]

    METHODS AND RESULTS:
    Analysis of the main triterpenoid profile of chloroform-soluble cuticular waxes of heather flowers and leaves by GC-MS revealed the following composition: four ketones - α-amyrenone, 4-epi-friedelin, friedelin and taraxerone and seven steroids - campesterol, cholesterol, sitostanol, sitosterol, stigmasterol, stigmasta-3,5-dien-7-one and Stigmastane-3,6-dione. Triterpenoids accounted for 20% and 65% by mass of flower and leaf waxes, respectively, which suggest that heather leaves represent a very promising source of these compounds.
    CONCLUSIONS:
    Ursolic acid was the principal triterpenoid in the cuticular wax of both organs, whereas among the neutral triterpenes, friedelin and uvaol were the most abundant in flowers and leaves, respectively. This report provides the first thorough overview of the triterpenoid composition of cuticular waxes of heather.