ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
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More articles cited ChemFaces products.
J Ethnopharmacol. 2017 Feb 23;Org Biomol Chem. 2017 Jul 25.Oncotarget. 2017 Jun 28;J. of Pha. and Biomed. Analysis25 Jan. 2016Chem Biol Interact. 2016 Dec 25
International Journal of Pharmacognosy.2015 7(1).Jour. of Stored Pro & Postharvest Res.March 2016J. Acta Agr. Scandinavica17 Apr 2017Molecules.2017 Oct 27;Phytomedicine2015 March 20.
Molecules 2016, 21(6), 780; 2016 Jun 17;21(6).Invest New Drugs. 2017 Apr;Chem Biol Interact.2018 Mar 1;Biol Pharm Bull. 2018;41(1):65-72.
Our products had been exported to the following research institutions and universities, And still growing.
Medical University of Gdansk (Poland)Institute of Chinese Materia Med... (China)Tohoku University (Japan)Leibniz Institute of Plant Bioch... (Germany)
Amity University (India)Charles Sturt University (Denmark)Universite Libre de Bruxelles (Belgium)Georgia Institute of Technology (USA)
Chinese University of Hong Kong (China)Stanford University (USA)University Medical Center Mainz (Germany)
|| Swertiaperennin is a natural product from Swertia bimaculata.|
|Planta Med. 2003 Aug;69(8):770-2. |
|The xanthones gentiacaulein and gentiakochianin are responsible for the vasodilator action of the roots of Gentiana kochiana.[Pubmed: 14531031]|
Gentiana kochiana Perr. et Song. (Gentianaceae), a plant used in the traditional medicine of Tuscany (Italy) as antihypertensive remedy, exerts a vasodilator action on in vitro aortic rings that is probably linked to the blocking of the ryanodine-sensitive Ca++ channels.
METHODS AND RESULTS:
In the present study, three known xanthones were isolated from the crude methanolic extract of the roots: gentiacaulein, gentiakochianin, and Swertiaperennin. The first two showed a vasorelaxing activity in rat aortic preparations, pre-contracted by 3 microM norepinephrine (pIC50 = 5.00 +/- 0.032 for gentiacaulein, pIC50 = 4.95 +/- 0.068 for gentiakochianin), 20 mM KCl (pIC50 = 4.90 +/- 0.15 for gentiacaulein; 4.59 +/- 0.069 for gentiakochianin), or 5 mM caffeine; on the contrary, in the same conditions, Swertiaperennin did not show any vasodilator effect.
In conclusion, gentiacaulein and gentiakochianin seem to be the compounds responsible for the vasorelaxing properties of the crude extract of Gentiana kochiana roots.
||The herbs of Swertia bimaculata
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.PMID: 29328914
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.PMID: 29149595
Scientific Reports 2017 Dec 11;7(1):17332.doi: 10.1038/s41598-017-17427-6.PMID: 29230013
Molecules. 2017 Oct 27;22(11). pii: E1829.doi: 10.3390/molecules22111829.PMID: 29077044
J Cell Biochem. 2018 Feb;119(2):2231-2239.doi: 10.1002/jcb.26385. PMID: 28857247
Phytomedicine. 2018 Feb 1;40:37-47. doi:10.1016/j.phymed.2017.12.030PMID: 29496173
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Records of Natural Products, 2016, 10(3):287-293. |
|Antiplasmodial Activity and Cytotoxicity of Isolated Compound from the Stem Bark of Anthocleistaliebrechtsiana[Reference: WebLink]|
METHODS AND RESULTS:
One new cerebroside derivative, namely liebrechtsianoside A (1), along with five known compounds: tetracosanoic acid (2), Swertiaperennin (3), decussatin (4), swertianin (5) and β-sitosterol glucoside (6) were isolated from the the stem bark of Anthocleista liebrechtsiana. Their structures were elucidated by interpretation of NMR and MS data, and by comparison of these data with those reported in literature.
Compound 1 showed the highest antiplasmodial activity against Dd2 chloroquine-resistant strain of Plasmodium falciparum.