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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $355.3 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
New Zealand J. Forestry Sci.2014, 44:17Molecular & Cellular Toxicology...2017...The Japan Society for Analytical ...2017...J Nat Med.2017, 71(2):457-462Front Plant Sci.2017, 8:723Journal of Analytical Chemistry...2017...J Chromatogr B Analyt Technol Bio...2018...Nat Prod Sci.2018, 24(3):206
Phytother Res.2018, 32(5):923-932Industrial Crops and Products...2018...Korean Journal of Pharmacognosy...2018...Front Immunol.2018, 9:2091Front Pharmacol.2018, 9:236J Cancer.2019, 10(23):5843-5851Cardiovasc Toxicol.2019, 19(4):297-305Molecules.2019, 24(12):E2286
Molecules.2019, 24(21):E3834Med Sci Monit.2019, 25:9499-9508Pak J Pharm Sci.2019, 32(6):2879-2885The Korea Journal of Herbology...2019...Chemistry of Natural Compounds...2019...Pharmacol Rep.2019, 71(2):289-298J Sep Sci.2020, 201901140
Our products had been exported to the following research institutions and universities, And still growing.
Instituto Politécnico de Bragan?a (Portugal)The Ohio State University (USA)Universidade Federal de Pernamb... (Brazil)University of Maryland (USA)
Universite de Lille1 (France)Martin Luther University of Hal... (Germany)Research Unit Molecular Epigene... (Germany)Kamphaengphet Rajabhat University (Thailand)
Lund University (Sweden)Shanghai University of TCM (China)Complutense University of Madrid (Spain)
Related Screening Libraries
||Tanshindiol C protects macrophages from oxLDL induced foam cell formation via activation of Prdx1/ABCA1 signaling and that Prdx1 may be a novel target for therapeutic intervention of atherosclerosis.It possesses a unique anti-cancer activity whose mechanism involves the inhibition of EZH2 activity and would provide chemically valuable information for designing a new class of potent EZH2 inhibitors.
||LDL | EZH2 | Prdx1 | ABCA|
|Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017, 1864(3):882-890. |
|Tanshindiol C inhibits oxidized low-density lipoprotein induced macrophage foam cell formation via peroxiredoxin 1 dependent pathway.[Reference: WebLink]|
|NF-E2-related factor 2 (Nrf2) has been shown to be protective in atherosclerosis. The loss of Nrf2 in macrophages enhances foam cell formation and promotes early atherogenesis. Tanshindiol C (Tan C) is isolated from the root of Salvia miltiorrhiza Bge., a traditional Chinese medicine that has been used for the treatment of several cardiovascular diseases for many years. This study was aimed to test the potential role of Tan C against macrophage foam cell formation and to explore the underlying mechanism.
METHODS AND RESULTS:
Firstly, we observed that Tan C markedly suppressed oxidized low-density lipoprotein (oxLDL) induced macrophage foam cell formation. Then, we found that Tan C was an activator of both Nrf2 and Sirtuin 1 (Sirt1) in macrophages. Nrf2 and Sirt1 synergistically activated the transcription of anti-oxidant peroxiredoxin 1 (Prdx1) after Tan C treatment. More important, we demonstrated that silencing of Prdx1 promoted oxLDL-induced macrophage foam cell formation. Prdx1 upregulated adenosine triphosphate-binding cassette (ABC) transporter A1 (ABCA1) expression and decreased intracellular lipid accumulation. Furthermore, Tan C ameliorated oxLDL induced macrophage foam cell formation in a Prdx1-dependent manner.
These observations suggest that Tan C protects macrophages from oxLDL induced foam cell formation via activation of Prdx1/ABCA1 signaling and that Prdx1 may be a novel target for therapeutic intervention of atherosclerosis.
|Bioorganic & Medicinal Chemistry Letters, 2014, 24(11):2486-2492. |
|Biological evaluation of tanshindiols as EZH2 histone methyltransferase inhibitors.[Reference: WebLink]|
|EZH2 is the core subunit of Polycomb repressive complex 2 catalyzing the methylation of histone H3 lysine-27 and closely involved in tumorigenesis. |
METHODS AND RESULTS:
To discover small molecule inhibitors for EZH2 methyltransferase activity, we performed an inhibitor screen with catalytically active EZH2 protein complex and identified tanshindiols as EZH2 inhibitors. Tanshindiol B and Tanshindiol C potently inhibited the methyltransferase activity in in vitro enzymatic assay with IC50 values of 0.52 μM and 0.55 μM, respectively. Tanshindiol C exhibited growth inhibition of several cancer cells including Pfeiffer cell line, a diffuse large B cell lymphoma harboring EZH2 A677G activating mutation. Tanshindiol treatment in Pfeiffer cells significantly decreased the tri-methylated form of histone H3 lysine-27, a substrate of EZH2, as revealed by Western blot analysis and histone methylation ELISA. Based on enzyme kinetics and docking studies, we propose that tanshindiol-mediated inhibition of EZH2 activity is competitive for the substrate S-adenosylmethionine.
Taken together, our findings strongly suggest that tanshindiols possess a unique anti-cancer activity whose mechanism involves the inhibition of EZH2 activity and would provide chemically valuable information for designing a new class of potent EZH2 inhibitors.
Tanshindiol C Description
||The roots of Salvia miltiorrhiza
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Recent ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Phytochemistry, 1985, 24(4):815-817. |
|Pigments from Salvia miltiorrhiza.[Reference: WebLink]|
METHODS AND RESULTS:
Five new o-naphthaquinone diterpenes, tanshindiol A, tanshindiol B, Tanshindiol C, nortanshinone and 3α-hydroxytanshinone IIA, have been isolated from the roots of Salvia miltiorrhiza as minor components. Their relative stereochemistries have been established on the basis of spectral and chemical evidence.