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    trans-4-Hydroxycinnamic acid
    Information
    CAS No. 501-98-4 Price $30 / 20mg
    Catalog No.CFN98794Purity>=98%
    Molecular Weight164.2 Type of CompoundPhenylpropanoids
    FormulaC9H8O3Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Trans-4-hydroxycinnamic acid has antimicrobial, and anti-oxidant activities.
    Targets: Antifection
    In vitro:
    Biosci Biotechnol Biochem. 1998 Nov;62(11):2273-6.
    Antimicrobial activity of 4-hydroxybenzoic acid and trans 4-hydroxycinnamic acid isolated and identified from rice hull.[Pubmed: 9972252]

    METHODS AND RESULTS:
    Two antimicrobial substances in rice hull were isolated and identified as 4-hydroxybenzoic acid and trans-4-Hydroxycinnamic acid by LC-MS, and 1H- and 13C-NMR. An evaluation of 50% inhibition of growth (IC50) revealed that the two substances had different inhibition profiles against various microorganisms.
    CONCLUSIONS:
    Most of the gram-positive and some gram-negative bacteria were sensitive to trans 4-hydroxycinnamic acid and 4-hydroxybenzoic acid at IC50 concentrations of 100-170 and 160 micrograms/ml, respectively.
    J. Pharm. Res., 2013, 6(2):313-7.
    In vitro evaluation of antioxidant and antibacterial activities of Rotula aquatica and Ancistrocladus heyneanus: Antioxidant and antimicrobial activity of medicinal plants.[Reference: WebLink]
    In the present study, the antioxidant and antimicrobial activities of the medicinal plants Rotula aquatica and Ancistrocladus heyneanus were evaluated.
    METHODS AND RESULTS:
    Antioxidant activity of the plant extracts was determined by total antioxidant capacity, ABTS and DPPH free radical scavenging activity, inhibitory activity toward β-carotene bleaching and lipid peroxidation, and DNA protection activity. Total phenolic and flavonoid contents were also estimated and the major phenolics present in the extract were identified by RP-HPLC. Significant free radical scavenging activity and marked antibacterial activity against food related bacteria Escherichia coli and Salmonella typhi were exhibited by the plant extracts used in the study.
    CONCLUSIONS:
    The work validates the ethnobotanical usage of the important medicinal plants R. aquatica and A. heyneanus. The plants used in the study possess significant antioxidant and antimicrobial property and have the potential for application in pharmaceutical and food industries as food supplements and natural preservatives.
    trans-4-Hydroxycinnamic acid Description
    Source: The herbs of Trifolium pratense.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.0901 mL 30.4507 mL 60.9013 mL 121.8027 mL 152.2533 mL
    5 mM 1.218 mL 6.0901 mL 12.1803 mL 24.3605 mL 30.4507 mL
    10 mM 0.609 mL 3.0451 mL 6.0901 mL 12.1803 mL 15.2253 mL
    50 mM 0.1218 mL 0.609 mL 1.218 mL 2.4361 mL 3.0451 mL
    100 mM 0.0609 mL 0.3045 mL 0.609 mL 1.218 mL 1.5225 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.