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    Traxillaside
    Traxillaside
    Information
    CAS No. 149415-62-3 Price
    Catalog No.CFN96608Purity>=98%
    Molecular Weight564.59Type of CompoundLignans
    FormulaC28H36O12Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Biological Activity
    Description: Traxillaside has significant neuroprotective activities against glutamate-induced toxicity in primary cultures of rat cortical cells .
    In vitro:
    Planta Med. 2001 Jul;67(5):470-2.
    Neuroprotective dibenzylbutyrolactone lignans of Torreya nucifera.[Pubmed: 11488466 ]

    METHODS AND RESULTS:
    The methanolic extract of the bark of Torreya nucifera Sieb. et Zucc. (Taxaceae) significantly protected primary cultures of rat cortical cells exposed to the excitotoxic amino acid, L-glutamate. (-)-Arctigenin (1), (-)-traxillagenin (2), arctiin (4), Traxillaside (5), and a newly-reported compound 3 (-)-4'-demethyltraxillagenin [(2R,3R)-2-(4''-hydroxy-3''-methoxybenzyl)-3-(4'-hydroxy-3',5'-dimethoxybenzyl)-butyrolactone] were isolated by bioactivity-guided fractionation and further separation using chromatographic techniques.
    CONCLUSIONS:
    These lignans and their glycosides had significant neuroprotective activities against glutamate-induced toxicity in primary cultures of rat cortical cells at concentrations ranging from 0.01 microM to 10.0 microM.
    Traxillaside Description
    Source: The barks of Torreya nucifera Sieb. et Zucc.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7712 mL 8.856 mL 17.712 mL 35.4239 mL 44.2799 mL
    5 mM 0.3542 mL 1.7712 mL 3.5424 mL 7.0848 mL 8.856 mL
    10 mM 0.1771 mL 0.8856 mL 1.7712 mL 3.5424 mL 4.428 mL
    50 mM 0.0354 mL 0.1771 mL 0.3542 mL 0.7085 mL 0.8856 mL
    100 mM 0.0177 mL 0.0886 mL 0.1771 mL 0.3542 mL 0.4428 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Zhongguo Zhong Yao Za Zhi. 2012 Jun;37(11):1581-5.
    Trace chemical constituents contained in Trachelospermum jasminoides and structure identification.[Pubmed: 22993985]
    To study trace chemical constituents contained in traditional Chinese medicine Trachelospermum jasminoides.
    METHODS AND RESULTS:
    The chemical constituents were separated and purified by using such column chromatographic methods as ployamide, silica gel, Sephadex LH-20 and ODS, and their structures were identified on the basis of spectral data analysis. Eleven compounds were separated from T. jasminoides and identified as bergenin (1), chrysoeriol-7-O-beta-D-glucoside (2), arctigenin-4'-O-beta-gentiobioside (3), matairesinol 4'-O-beta-gentiobioside (4), traxillagenin (5), Traxillaside (6), 4-demethyltraxillagenin (7), luteolin-7-O-beta-gentiobioside (8), arctiin (9), trachelogenin-4'-O-beta-gentiobioside (10) and luteolin-7-O-beta-D-glucoside (11).
    CONCLUSIONS:
    Compounds 1 and 2 were separated from Trachelospermum genus for the first time, while compounds 3-7 were separated from this plant for the first time.