• ChemFaces is a professional high-purity natural products manufacturer.
  • Product Intended Use
  • 1. Reference standards
  • 2. Pharmacological research
  • 3. Inhibitors
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • Natural Products
    Vinblastine Sulfate
    Information
    CAS No. 143-67-9 Price $100 / 20mg
    Catalog No.CFN90146Purity>=98%
    Molecular Weight909.06Type of CompoundAlkaloids
    FormulaC46H58N4O9.H2SO4Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $65.0 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • University of Beira Interior (Portugal)
  • Chungnam National University (Korea)
  • Center for protein Engineering ... (Belgium)
  • University of Indonesia (Indonesia)
  • University of Parma (Italy)
  • Yale University (USA)
  • Martin Luther University of Hal... (Germany)
  • Fraunhofer-Institut für Moleku... (Germany)
  • The University of Newcastle (Australia)
  • Harvard University (USA)
  • Universidade Federal de Santa C... (Brazil)
  • More...
  • Package
    Featured Products
    Linderalactone

    Catalog No: CFN99761
    CAS No: 728-61-0
    Price: $198/20mg
    Scopolin

    Catalog No: CFN98887
    CAS No: 531-44-2
    Price: $168/20mg
    Ginsenoside Rh3

    Catalog No: CFN99972
    CAS No: 105558-26-7
    Price: $218/20mg
    Sophoraflavanone G

    Catalog No: CFN92005
    CAS No: 97938-30-2
    Price: $138/20mg
    Pomolic acid

    Catalog No: CFN99433
    CAS No: 13849-91-7
    Price: $413/5mg
    Salvigenin

    Catalog No: CFN99883
    CAS No: 19103-54-9
    Price: $338/10mg
    Ganoderol A

    Catalog No: CFN99065
    CAS No: 104700-97-2
    Price: $488/5mg
    Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anticancer Compound Library
  • Radioprotectants Compound Library
  • Alkaloids Compound Library
  • DNA/RNA Synthesis Inhibitor Library
  • Biological Activity
    Description: Vinblastine Sulfate has anticancer activity, using FA-BSANPs as a drug carrier system could be effective in targeting Vinblastine Sulfate-sensitive tumors in the future. Vinblastine Sulfate could offer protection to the normal tissues against gamma-radiation-induced DNA strand breaks. The changes induced on the rabbit OM by Vinblastine sulphate are transient and that regenerative recovery leads to the restoration of the normal structure of the mucosa.
    Targets: DNA/RNA Synthesis
    In vitro:
    Mutat Res. 2003 Apr 20;536(1-2):15-25.
    Effect of vinblastine sulfate on gamma-radiation-induced DNA single-strand breaks in murine tissues.[Pubmed: 12694742]
    The effect of Vinblastine Sulfate on gamma-radiation-induced DNA strand breaks in different tissues of tumour bearing mice, was studied by single-cell gel electrophoresis.
    METHODS AND RESULTS:
    Intraperitonial administration of different doses (0.25-2.0mg/kg body weight) of Vinblastine Sulfate 30 min prior to 4 Gy gamma-radiation exposure showed a dose-dependent decrease in the yield of DNA strand breaks in murine fibrosarcoma, blood leukocytes and bone marrow cells. The dose-dependent protection of cellular DNA against radiation-induced strand breaks as evidenced from comet tail length, tail moment and percent DNA in the tail, was more pronounced in bone marrow cells than in the cells of the tumor fibrosarcoma. In fibrosarcoma cells, the decrease in comet tail length, tail moment and percent DNA in the tail was detected at lower doses of Vinblastine Sulfate administration and these parameters were not significantly altered at higher doses, from that of the control irradiated.
    CONCLUSIONS:
    From this study, it appears that in addition to anticancer activity, Vinblastine Sulfate could offer protection to the normal tissues against gamma-radiation-induced DNA strand breaks.
    In vivo:
    Anat Histol Embryol. 2012 Oct;41(5):374-87.
    Anticancer drug vinblastine sulphate induces transient morphological changes on the olfactory mucosa of the rabbit.[Pubmed: 22443492]
    Vinblastine Sulfate (VBS) is an anticancer drug that acts by disrupting microtubule dynamics of highly mitotic tissue cells. The consequences of Vinblastine sulphate on the olfactory mucosa (OM), a tissue with high mitotic numbers, are not clearly understood.
    METHODS AND RESULTS:
    We used qualitative and quantitative methods to determine the structural changes that may be produced on the rabbit OM by Vinblastine sulphate. Following a single dose (0.31 mg/kg) of this drug, the structure of the mucosa was greatly altered on the first 3-5 days. The alteration was characterized by disarrangement of the normal layering of nuclei of the epithelia, degeneration of axonal bundles, occurrence of blood vessels within the bundles, localized death of cells of Bowman's glands and glandular degeneration. Surprisingly on or after day 7 and progressively to day 15 post-exposure, the OM was observed to regenerate and acquire normal morphology, and the vessels disappeared from the bundles. Relative to control values, bundle diameters, olfactory cell densities and cilia numbers decreased to as low as 53.1, 75.2 and 71.4%, respectively, on day 5. Volume density for the bundles, which was 28.6% in controls, decreased to a lowest value of 16.8% on day 5. In contrast, the volume density for the blood vessels was significantly lower in controls (19.9%) than in treated animals at day 2 (25.8%), day 3 (34.3%) and day 5 (31.5%).
    CONCLUSIONS:
    These findings suggest that the changes induced on the rabbit OM by Vinblastine sulphate are transient and that regenerative recovery leads to the restoration of the normal structure of the mucosa.
    Can Med Assoc J. 1970 Feb 14;102(3):278-80.
    A comparison of nitrogen mustard and vinblastine sulfate in the treatment of patients with Hodgkin's disease.[Pubmed: 5414540]

    METHODS AND RESULTS:
    In a crossover study the effectiveness of intermittent maintenance doses of nitrogen mustard was compared to that of Vinblastine Sulfate in the treatment of 61 patients with advanced Hodgkin's disease. Forty-five of the patients had had previous radiation therapy. Nine of 29 patients who received nitrogen mustard as the first drug had a complete response and five had a partial response. The comparative results in 32 patients receiving Vinblastine Sulfate first were nine complete responses and 13 partial responses. The median duration of the complete responses to each drug was 43 weeks. The partial responses were of shorter duration. When the second drug was given in adequate doses, almost as many patients responded with a similar median duration of response.
    CONCLUSIONS:
    It is concluded that nitrogen mustard and Vinblastine Sulfate are equally effective single agents in the treatment of patients with advanced Hodgkin's disease and that patient preference would favour Vinblastine Sulfate because of its negligible side effects.
    Vinblastine Sulfate Description
    Source: The herbs of Catharanthus roseus (L.)G. Don
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Recent ChemFaces New Products and Compounds
    Isopsoralenoside

    Catalog No: CFN92225
    CAS No: 905954-18-9
    Price: $338/5mg
    Silychristin B

    Catalog No: CFN95160
    CAS No: 879325-58-3
    Price: $318/5mg
    (+)-Epipinoresinol

    Catalog No: CFN92288
    CAS No: 24404-50-0
    Price: $338/5mg
    4-O-Feruloylquinic acid

    Catalog No: CFN92392
    CAS No: 2613-86-7
    Price: $448/5mg
    Ginsenoside Rk2

    Catalog No: CFN92818
    CAS No: 364779-14-6
    Price: $498/10mg
    meso-Hannokinol

    Catalog No: CFN90864
    CAS No: N/A
    Price: $368/5mg
    Angelol H

    Catalog No: CFN91925
    CAS No: 83247-73-8
    Price: $338/5 mg
    Kobophenol A

    Catalog No: CFN92530
    CAS No: 124027-58-3
    Price: $318/10mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.1 mL 5.5002 mL 11.0004 mL 22.0007 mL 27.5009 mL
    5 mM 0.22 mL 1.1 mL 2.2001 mL 4.4001 mL 5.5002 mL
    10 mM 0.11 mL 0.55 mL 1.1 mL 2.2001 mL 2.7501 mL
    50 mM 0.022 mL 0.11 mL 0.22 mL 0.44 mL 0.55 mL
    100 mM 0.011 mL 0.055 mL 0.11 mL 0.22 mL 0.275 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Int J Nanomedicine. 2009;4:321-33. Epub 2009 Dec 29.
    Optimization of the preparation process of vinblastine sulfate (VBLS)-loaded folate-conjugated bovine serum albumin (BSA) nanoparticles for tumor-targeted drug delivery using response surface methodology (RSM).[Pubmed: 20054435]
    Response surface methodology (RSM) was used to optimize the process of preparing bovine serum albumin (BSA) nanoparticles by desolvation, then the resulting BSA nanoparticles (BSANPs) were conjugated with folate to produce a drug carrier system that can specifically target tumors.
    METHODS AND RESULTS:
    The anticancer drug, Vinblastine Sulfate (VBLS), was loaded to this tumor-specific drug carrier system for the purpose of overcoming the nonspecific targeting characteristics and side effects of the drug. A central composite design was applied for modeling the process, which was composed of four independent variables, namely BSA concentration, the rate of adding ethanol (ethanol rate), ethanol amount, and the degree of crosslinking. The mean particle size and residual amino groups of the BSANPs were chosen as response variables. The interactive effects of the four independent variables on the response variables were studied. The characteristics of the nanoparticles; such as amount of folate conjugation, drug entrapment efficiency, drug-loading efficiency, surface morphology and release kinetics in vitro were investigated. Optimum conditions for preparing desired BSANPs, with a mean particle size of 156.6 nm and residual amino groups of 668.973 nM/mg, were obtained. The resulting folate-conjugated BSANPs (FA-BSANPs) showed a drug entrapment efficiency of 84.83% and drug-loading efficiency of 42.37%, respectively, and the amount of folate conjugation was 383.996 microM/g BSANPs.
    CONCLUSIONS:
    The results of this study indicate that using FA-BSANPs as a drug carrier system could be effective in targeting Vinblastine Sulfate-sensitive tumors in the future.