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    Withaperuvin C
    Withaperuvin C
    Information
    CAS No. 81644-34-0 Price
    Catalog No.CFN96433Purity>=98%
    Molecular Weight486.59Type of CompoundSteroids
    FormulaC28H38O7Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
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  • Biological Activity
    Description: Withaperuvin C may have anti-inflammatory activity with lipopolysaccharide (LPS)-activated murine macrophage RAW 264.7 cells.
    Targets: TNF-α | NF-kB
    In vitro:
    Hawaii J Med Public Health. 2016 Nov;75(11):353-359.
    The Daniel K. Inouye College of Pharmacy Scripts: Poha Berry (Physalis peruviana) with Potential Anti-inflammatory and Cancer Prevention Activities.[Pubmed: 27920947 ]
    The edible fruits are commonly known as cape gooseberry or poha in Hawai'i.
    METHODS AND RESULTS:
    In part of our study, three new withanolides, physaperuvin G (1), physaperuvins I-J (2-3), along with four known withanolides, namely, 4β-hydroxywithanolide E (4), Withaperuvin C (5), and physalactone (6), coagulin (7) were isolated from the aerial parts of P. peruviana. In addition, two known compounds, phyperunolide F (8), and withanolide S (9), were isolated and identified from the poha berry fruits. The structures and absolute stereochemistry of new compounds from poha were elucidated by several spectroscopy methods: Nuclear Magnetic Resonance (NMR) spectroscopy, X-ray diffraction, and mass spectrometry analyses.
    CONCLUSIONS:
    All isolated poha compounds (aerial parts and fruits) were evaluated for their anti-inflammatory activity with lipopolysaccharide (LPS)-activated murine macrophage RAW 264.7 cells, and tumor necrosis factor alpha (TNF-α)-activated nuclear factor-kappa B (NF-κB) with transfected human embryonic kidney cells 293. Most of the isolated natural compounds showed activity with these assays.
    Withaperuvin C Description
    Source: The herbs of Physali alkekengi
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0551 mL 10.2756 mL 20.5512 mL 41.1024 mL 51.378 mL
    5 mM 0.411 mL 2.0551 mL 4.1102 mL 8.2205 mL 10.2756 mL
    10 mM 0.2055 mL 1.0276 mL 2.0551 mL 4.1102 mL 5.1378 mL
    50 mM 0.0411 mL 0.2055 mL 0.411 mL 0.822 mL 1.0276 mL
    100 mM 0.0206 mL 0.1028 mL 0.2055 mL 0.411 mL 0.5138 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.