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    Yadanzioside G
    Yadanzioside G
    Information
    CAS No. 95258-17-6 Price $413 / 5mg
    Catalog No.CFN96422Purity>=93%
    Molecular Weight768.76Type of CompoundDiterpenoids
    FormulaC36H48O18Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)
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    Our products had been exported to the following research institutions and universities, And still growing.
  • Ain Shams University (Egypt)
  • Complutense University of Madrid (Spain)
  • Shanghai Institute of Biochemist... (China)
  • Korea Intitute of Science and Te... (Korea)
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    Biological Activity
    Description: Yadanzioside G has antileukemic activity.
    In vitro:
    Phytother Res. 2011 Dec;25(12):1796-800.
    Seven quassinoids from Fructus Bruceae with cytotoxic effects on pancreatic adenocarcinoma cell lines.[Pubmed: 21480411 ]
    Our previous studies showed that the alcohol extract of the fruit of Brucea javanica (Fructus Bruceae) possessed significant cytotoxicity in pancreatic adenocarcinoma cell lines.
    METHODS AND RESULTS:
    A bioassay-guided fractionation and purification resulted in the isolation and characterization of seven quassinoids including brusatol, bruceine D, bruceine H, yadanzioside A, Yadanzioside G, javanicoside C and bruceantinoside A. Among them, brusatol exhibited the most potent in vitro antipancreatic cancer action, with IC(50) values of 0.36 μm and 0.10 μm on PANC-1 and SW1990 cell lines, respectively.
    CONCLUSIONS:
    This is the first report on the antipancreatic adenocarcinoma activity of brusatol.
    Bull. Chem. Soc. Jpn.,1985, 58(9), 2680-6.
    Structures of new quassinoid glycosides, yadanziosides A,B,C,D,E,G,H, and new quassinoids, dehydrobrusatol and dehydrobruceantinol from Brucea javanica (L.) Merr.[Reference: WebLink]

    METHODS AND RESULTS:
    Quassinoid glycosides, yadanzioside A, yadanzioside B, yadanzioside C, yadanzioside D, yadanzioside E, Yadanzioside G, and yadanzioside H, and two quassinoids, dehydrobrusatol and dehydrobruceantinol were isolated from seeds of Brucea javanica, and their structures were determined.
    CONCLUSIONS:
    These glycosides showed bitter taste and were demonstrated to have antileukemic activity.
    Yadanzioside G Description
    Source: The seeds of Brucea javanica.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

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    doi: 10.3390/molecules22111829.

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3008 mL 6.504 mL 13.008 mL 26.0159 mL 32.5199 mL
    5 mM 0.2602 mL 1.3008 mL 2.6016 mL 5.2032 mL 6.504 mL
    10 mM 0.1301 mL 0.6504 mL 1.3008 mL 2.6016 mL 3.252 mL
    50 mM 0.026 mL 0.1301 mL 0.2602 mL 0.5203 mL 0.6504 mL
    100 mM 0.013 mL 0.065 mL 0.1301 mL 0.2602 mL 0.3252 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Arch Pharm Res. 2011 Aug;34(8):1297-300.
    One new pregnane glycoside from the seeds of cultivated Brucea javanica.[Pubmed: 21910051 ]
    A new pregnane glycoside, named (20R)-O-(3)-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl-pregn-5-en-3β,20-diol (1), and seven known compounds, brusatol (2), bruceine B (3), bruceine D (4), yadanziolide A (5), bruceine E (6), Yadanzioside G (7), and yadanzioside B (8), were isolated from the cultivated dry seeds of Brucea javanica.
    METHODS AND RESULTS:
    The structure of 1 was elucidated on the basis of 1D- and 2D-NMR spectroscopic analyses. Their inhibitory effects on tumor cells were also tested. Compound 1 was slightly active against HL-60, SMMC-7721, A-549, and MCF-7 tumor cells. Compounds 2 and 3 demonstrated significant inhibitory activities against all tested cells.
    CONCLUSIONS:
    These results indicate that cultivated B. javanica could replace the wild plant as an antitumor plant resource