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    Beta-Carotene
    Information
    CAS No. 7235-40-7 Price $40 / 20mg
    Catalog No.CFN98117Purity>=98%
    Molecular Weight536.88Type of CompoundMiscellaneous
    FormulaC40H56Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $36.5 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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  • Biological Activity
    Description: Beta Carotene is an organic compound and classified as a terpenoid. It is a precursor (inactive form) of vitamin A. Beta-Carotene has antioxidant activity, anti-cancer, and antiapoptotic activities, it has protective effects against gamma-radiation-induced in vivo chromosomal damage. Dietary supplementation of carotenoids may act as moderate hypocholesterolemic agents, secondary to their inhibitory effect on macrophage 3-hydroxy-3-methyl glutaryl coenzyme A (HMGCoA) reductase, the rate limiting enzyme in cholesterol synthesis.
    Targets: SOD | Caspase | LDL | HMG-CoA Reductase | MMP(e.g.TIMP) | HIF | GLUT
    In vitro:
    Biochem Biophys Res Commun. 1997 Apr 28;233(3):658-62.
    Hypocholesterolemic effect of lycopene and beta-carotene is related to suppression of cholesterol synthesis and augmentation of LDL receptor activity in macrophages.[Pubmed: 9168909 ]
    Beta-Carotene and lycopene are derived from plants, and they share similar initial synthetic pathway with cholesterol, which is synthesized in animal but not in plant cells. Thus, we sought to analyze the effect of carotenoids on macrophage cholesterol metabolism, in comparison to the effect of LDL cholesterol and of the cholesterol synthesis inhibitor, fluvastatin. In J-774 A. 1 macrophage cell line, the cellular cholesterol synthesis from [3H]-acetate, but not from [14C] mevalonate, was suppressed by 63% any by 73% following cell incubation with Beta-Carotene or lycopene (10 microM) respectively, in comparison to a 90% and 91% inhibition by LDL (100 micrograms of cholesterol), or by fluvastatin (10 micrograms/ml) respectively. However, unlike LDL derived cholesterol, which also suppresses macrophage LDL receptor activity, lycopene and Beta-Carotene augmented the activity of the macrophage LDL receptor, similarly to the effect of fluvasfatin. In agreement with these in vitro observations, dietary supplementation of tomato's lycopene (60 mg/day) to 6 males for a 3 months period resulted in a significant 14% reduction in their plasma LDL cholesterol concentrations.
    CONCLUSIONS:
    We thus conclude that dietary supplementation of carotenoids may act as moderate hypocholesterolemic agents, secondary to their inhibitory effect on macrophage 3-hydroxy-3-methyl glutaryl coenzyme A (HMGCoA) reductase, the rate limiting enzyme in cholesterol synthesis.
    J Nutr Biochem. 2014 Jun;25(6):655-64.
    β-Carotene inhibits neuroblastoma cell invasion and metastasis in vitro and in vivo by decreasing level of hypoxia-inducible factor-1α.[Pubmed: 24746828]
    While Beta-Carotene is a vitamin A precursor that has been shown to exert antioxidant and anticancer effects, the anti-metastatic effects of Beta-Carotene on neuroblastoma cells remain poorly understood. The aim of the present study was to investigate the anti-metastatic effects of Beta-Carotene on highly malignant SK-N-BE(2)C neuroblastoma cells in vitro and in vivo.
    METHODS AND RESULTS:
    Treatment of SK-N-BE(2)C cells with Beta-Carotene was found to attenuate the migratory and invasive capabilities of the cells. In addition, the enzymatic activity and expression of matrix metalloproteinase (MMP)-2 was suppressed following Beta-Carotene treatment under both normoxia and hypoxia. To induce metastasis, immunodeficient nude mice were injected with SK-N-BE(2)C cells via the tail vein in vivo. The incidence of liver metastasis and mean tumor volume in mice that were administered Beta-Carotene was decreased compared to controls. Furthermore, mRNA levels of MMPs, membrane-type (MT) 2 MMP and tissue inhibitors of metalloproteinases in liver tumor tissues were also lower following Beta-Carotene treatment. Level of hypoxia-inducible factor-1α (HIF-1α) and its downstream targets, vascular endothelial growth factor and glucose transporter 1 (GLUT1), were lower both in vitro and in vivo following Beta-Carotene treatment.
    CONCLUSIONS:
    In conclusion, the present study provides the first evidence that Beta-Carotene may represent an effective chemotherapeutic agent by regulating the invasion and metastasis of neuroblastoma via HIF-1α.
    In vivo:
    Mutat Res. 1993 Nov;303(3):109-12.
    Protective effects of chlorogenic acid, curcumin and beta-carotene against gamma-radiation-induced in vivo chromosomal damage.[Pubmed: 7694126]
    The mouse bone marrow micronucleus test was carried out to evaluate the possible role of the dietary constituents chlorogenic acid (CGA), curcumin (CR) and Beta-Carotene (BC) in modulating the in vivo chromosomal damage induced by gamma-radiation.
    METHODS AND RESULTS:
    The results obtained suggest that oral administration of CGA (50, 100 and 200 mg/kg b.w.), CR (5, 10 and 20 mg/kg b.w.) and BC (0.5 and 2.5 mg/kg b.w.) to mice can significantly reduce the frequencies of micronucleated polychromatic erythrocytes (Mn PCEs) induced by whole body exposure to gamma-radiation (1.15 Gy; 0.05 Gy/s). With CGA and CR, this effect was observed after a single administration either 2 h before or immediately after irradiation. However, with BC a 7-day feeding before irradiation was necessary to obtain a significant reduction in the incidence of Mn PCEs.
    CONCLUSIONS:
    The protective effects of CGA, CR and BC were observed in bone marrow cells sampled 24, 30 and 48 h after exposure to radiation.
    Beta-Carotene Description
    Source: The roots of Daucus carota
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8626 mL 9.3131 mL 18.6261 mL 37.2523 mL 46.5653 mL
    5 mM 0.3725 mL 1.8626 mL 3.7252 mL 7.4505 mL 9.3131 mL
    10 mM 0.1863 mL 0.9313 mL 1.8626 mL 3.7252 mL 4.6565 mL
    50 mM 0.0373 mL 0.1863 mL 0.3725 mL 0.745 mL 0.9313 mL
    100 mM 0.0186 mL 0.0931 mL 0.1863 mL 0.3725 mL 0.4657 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Cell Research:
    Cancer Lett. 1992 Apr 15;63(2):125-33.
    Inhibitory effect of conjugated dienoic derivatives of linoleic acid and beta-carotene on the in vitro growth of human cancer cells.[Pubmed: 1562989]
    The effects of physiologic concentrations of conjugated linoleic acid (CLA) and Beta-Carotene were assessed on human (M21-HPB, malignant melanoma; HT-29, colorectal; MCF-7, breast) cancer cells.
    METHODS AND RESULTS:
    The incubation of cancer cells with CLA showed significant reductions in proliferation (18-100%) compared to control cultures. M21-HPB and MCF-7 cell mortality was dose- and time-dependent. Beta-Carotene was inhibitory to breast cells only. MCF-7 cells supplemented with CLA incorporated significantly less [3H]leucine (45%), [3H]uridine (63%) and [3H]thymidine (46%) than control cultures. M21-HPB and HT-29 cells supplemented with CLA incorporated less [3H]leucine (25-30%).
    CONCLUSIONS:
    These in vitro results suggest that CLA and Beta-Carotene may be cytotoxic to human cancer cells in vivo.
    Animal Research:
    Fertil Steril. 2009 Dec;92(6):2028-33.
    Antiapoptotic and antioxidant effects of beta-carotene against methotrexate-induced testicular injury.[Pubmed: 19046577]
    In each group, 100 tubules were classified as intact, sloughing, atrophic, and degenerated. Caspase-3, a universal effector of apoptosis, was evaluated according to staining in place of coloring as weak, mild, and strong. RESULT(S): To investigate the effect of Beta-Carotene against testicular injury induced by methotrexate (MTX).
    METHODS AND RESULTS:
    Twenty-eight rats were separated into four groups: control, Beta-Carotene, MTX, and Beta-Carotene + MTX. At the end of the treatment, the animals were killed, and tissue samples were examined via histologic and biochemical methods. In each group, 100 tubules were classified as intact, sloughing, atrophic, and degenerated. Caspase-3, a universal effector of apoptosis, was evaluated according to staining in place of coloring as weak, mild, and strong. In the MTX group, 58.5 + 3.7% of tubules were sloughing, 10.8 + 2.1% of tubules were atrophic, and 2.0 + 0.6% of tubules were degenerative. In the Beta-Carotene + MTX group, the affected tubule number was statistically significantly lower than in the MTX group. The distribution of caspase-3 in the MTX group showed a statistically significant increase, but it decreased in the Beta-Carotene + MTX group. The enzyme activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GP-x) and the level of malondialdehyde (MDA) increased and decreased in parallel.
    CONCLUSIONS:
    Our results indicate that Beta-Carotene may be useful in decreasing the side effects of chemotherapy, including apoptotic cell death.
    Structure Identification:
    J Food Sci. 2014 Sep;79(9):C1688-94.
    β-Carotene as a membrane antioxidant probed by cholesterol-anchored daidzein.[Pubmed: 25103027]

    METHODS AND RESULTS:
    Beta-Carotene is found to be more effective as an antioxidant in phosphatidylcholine (PC) liposomes when protecting against hydrophilic radicals compared to lipophilic radicals, as measured by the rate of formation of conjugated dienes. Daidzein alone is without effect, but decreases the antioxidative effect of Beta-Carotene for hydrophilic initiation and increases the effect for lipophilic initiation. The newly synthesized 7-cholesterylglycol daidzein has the opposite effect for Beta-Carotene as antioxidant, with a strong enhancement for hydrophilic initiation and a slight decrease for lipophilic initiation.
    CONCLUSIONS:
    Redistributing Beta-Carotene to membrane surfaces by cholesterol-anchoring of daidzein enhances protection against aqueous radicals significantly at the expense of protection against lipid-derived radicals.