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    gamma-Fagarine
    gamma-Fagarine
    Information
    CAS No. 524-15-2 Price
    Catalog No.CFN98858Purity>=98%
    Molecular Weight229.2 Type of CompoundAlkaloids
    FormulaC13H11NO3Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)
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    gamma-Fagarine Description
    Source: The fruits of Zanthoxylum simulans Hance
    Biological Activity or Inhibitors: 1. gamma-Fagarine possesses moderate levels of anti-HCV activities with IC₅₀ values being 20.4 ± 0.4 ug/ml, respectively.
    2. gamma-Fagarine has sister chromatid exchanges (SCEs)-inducing activity, it induces SCEs in human lymphocyte cultures in a dose-dependent manner.
    3. gamma-Fagarine and dictamnine are mutagenic in strain TA100 and TA98 with S9 mix, they have specific activities (His+/microgram) of about 50-70 revertant colonies in strain TA100, while in strain TA98 there are about 30-50 revertant colonies.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.363 mL 21.815 mL 43.63 mL 87.26 mL 109.075 mL
    5 mM 0.8726 mL 4.363 mL 8.726 mL 17.452 mL 21.815 mL
    10 mM 0.4363 mL 2.1815 mL 4.363 mL 8.726 mL 10.9075 mL
    50 mM 0.0873 mL 0.4363 mL 0.8726 mL 1.7452 mL 2.1815 mL
    100 mM 0.0436 mL 0.2182 mL 0.4363 mL 0.8726 mL 1.0908 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    gamma-Fagarine References Information
    Citation [1]

    Fitoterapia. 2014 Dec;99:276-83.

    Inhibition of hepatitis C virus replication by chalepin and pseudane IX isolated from Ruta angustifolia leaves.[Pubmed: 25454460]
    We isolated six compounds, chalepin, scopoletin, gamma-Fagarine, arborinine, kokusaginine and pseudane IX. Among them, chalepin and pseudane IX showed strong anti-HCV activities with 50% inhibitory concentration (IC₅₀) of 1.7 ± 0.5 and 1.4 ± 0.2 μg/ml, respectively, without apparent cytotoxicity. Their anti-HCV activities were stronger than that of ribavirin (2.8 ± 0.4 μg/ml), which has been widely used for the treatment of HCV infection. Mode-of-action analyses revealed that chalepin and pseudane IX inhibited HCV at the post-entry step and decreased the levels of HCV RNA replication and viral protein synthesis. We also observed that arborinine, kokusaginine and gamma-Fagarine possessed moderate levels of anti-HCV activities with IC₅₀ values being 6.4 ± 0.7, 6.4 ± 1.6 and 20.4 ± 0.4 μg/ml, respectively, whereas scopoletin did not exert significant anti-HCV activities at 30 μg/ml.
    Citation [2]

    Mutagenesis. 1989 Nov;4(6):467-70.

    The SCE-inducing potency of the furoquinoline alkaloid, gamma-fagarine, and a gamma-fagarine-containing tincture from Rutae Herba, in cultured human lymphocytes.[Pubmed: 2695761]
    gamma-Fagarine, a furoquinoline alkaloid naturally occurring in Rutae Herba induces sister chromatid exchanges (SCEs) in human lymphocyte cultures in a dose-dependent manner. The alkaloid is a direct-acting but weak SCE inducer. Similar direct but weak activity was detected in a sample of a commercial Rutae Tinctura which contained 68 micrograms/ml of gamma-Fagarine. The strong toxicity of the tincture makes it difficult to test a broader concentration range. There is some evidence that the SCE-inducing activity of the tincture is mainly due to the presence of gamma-Fagarine.
    Citation [3]

    Mutat Res. 1985 Dec;144(4):221-5.

    Mutagenic activities of dictamnine and gamma-fagarine from dictamni radicis cortex (Rutaceae).Mutagenic activities of dictamnine and gamma-fagarine from dictamni radicis cortex (Rutaceae).[Pubmed: 4069140]
    A methanol extract of Dictamni Radicis Cortex exhibited a mutagenic effect on Salmonella typhimurium TA100 and TA98 with S9 mix. Two mutagenic compounds in Dictamni Radicis Cortex were isolated on a Sephadex LH 20 column and silica gel column chromatography and by preparative TLC. These were identified as dictamnine and gamma-Fagarine by UV, EI-Mass, 1H-NMR. Dictamnine and gamma-Fagarine were mutagenic in strain TA100 and TA98 with S9 mix. The dose-response curves were linear in the range 10-40 micrograms. Dictamnine and gamma-Fagarine had specific activities (His+/microgram) of about 50-70 revertant colonies in strain TA100, while in strain TA98 there were about 30-50 revertant colonies.