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    Crocin I
    Information
    CAS No. 94238-00-3 Price $100 / 20mg
    Catalog No.CFN99927Purity>=98%
    Molecular Weight976.96Type of CompoundDiterpenoids
    FormulaC44H64O24Physical DescriptionPowder
    Download Manual    COA    MSDSSimilar structuralComparison (Web)
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  • Package
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    Biological Activity
    Description: 1. Crocin has anti-inflammatory and anti-apoptotic effects against gastric ischemia-reperfusion injury in rats, the effect of crocin is mainly mediated by reducing the protein expression of iNOS and caspase-3.
    2. Crocin can ameliorate CCl4-induced liver injury via inhibition of inflammatory cytokines, caspase3 and oxidative stress along with modulation of liver metabolizing enzymes favoring elimination of CCl4 toxic metabolite.
    3. Crocin has antihyperlipidemic effect, may be due to the inhibition of pancreatic lipase and crocin, and its metabolite, crocetin, can improve hyperlipidemia.
    4. Crocin has antidepressant effects by increasing CREB, BDNF and VGF levels in hippocampus.
    Targets: NOS | Caspase
    Crocin I Description
    Source: The stigma of Crocus sativus L.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.0236 mL 5.1179 mL 10.2358 mL 20.4717 mL 25.5896 mL
    5 mM 0.2047 mL 1.0236 mL 2.0472 mL 4.0943 mL 5.1179 mL
    10 mM 0.1024 mL 0.5118 mL 1.0236 mL 2.0472 mL 2.559 mL
    50 mM 0.0205 mL 0.1024 mL 0.2047 mL 0.4094 mL 0.5118 mL
    100 mM 0.0102 mL 0.0512 mL 0.1024 mL 0.2047 mL 0.2559 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Crocin I References Information
    Citation [1]

    J Food Sci Technol. 2014 Aug;51(8):1575-81.

    Homogenate extraction of gardenia yellow pigment from Gardenia Jasminoides Ellis fruit using response surface methodology.[Pubmed: 25114350]
    Homogenate extraction technology was developed for extraction of Crocin I pigment from Gardenia jasminoides Ellis fruit. The operating parameters affecting the color value of Crocin I pigment were studied on the basis of a Box-Behnken design and response surface methodology. Results showed that the optimum extraction conditions were as follows: extraction time 41 s, ethanol concentration 50 %, ratio of liquid to material 15:1 (mL:g) and particle size 1.7 mm. Under the optimum condition, the experimental color value was 52.37 g(-1), which was in keeping with the predicted one. Compared with the heat extraction method, the color value of gardenia yellow pigment of homogenate extraction was higher and the extraction time was shorter. Homogenate extraction method is an ideal means for extraction of Crocin I pigment from Gardenia jasminoides Ellis fruit.