|T10164||1mg/well * 67 Compounds||Inquiry||In stock|| |
|T10164||100uL/well (10mM solution) * 67 Compounds||Inquiry||In stock|
|Manufacturer||Wuhan ChemFaces Biochemical Co., Ltd.|
|Container||96 Well Format Sample|
|Storage||Protected from air and light, refrigerate or freeze(2-8 °)|
|Shelf Life||24 months (2-8 °)|
|Intended Use||For research use only. Not for human use. Not sell to patients|
|1. The products in the ChemFaces screening libraries are all from plants.|
|2. The biological activities or pharmacological activities of all the ChemFaces products are derived from the databases of all over the world the latest literatures, you can according to the product manuals on our website to access the relevant literatures, hope that our informations can give some inspirations and help to your research.|
|3.The collections of unique natural products, which include antioxidants, anti-inflammatory, antibacterial, anticancer, and ect. Can be used for high throughput screening (HTS) and high content screening (HCS), is to help you carry out new drug screening, the emergence of new indications and other professional tools.|
|4.Structurally diverse, medicinally active, and cell permeable, NMR and HPLC validated to ensure high purity.|
|5. ChemFaces offers customized bioactive screening libraries , whereby you choose the specific compounds you want in the library, the quantities, plate map, concentration, and format (dry/solid or DMSO solution).|
Galanolactone has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors, it has inhibit nitric oxide production with IC(50) values ranging from 5.5 to 28.5 μM. Galanolactone exerts anti-obesity effect through down regulation of adipogenic transcription factors and adipogenic marker genes.Galanolactone also shows cytotoxic activity .
1,2-Dihydroxybenzene can induce spontaneous convulsive activity in the anaesthetized mouse and produce myoclonic jerks in the rat. It regulated 5-Hydroxytryptamine (5-HT) levels.
Auraptenol possesses robust antidepressant-like efficacy in mice. It has potential to be a novel analgesic for the management of neuropathic pain, it attenuates vincristine-induced mechanical hyperalgesia through serotonin 5-HT1A receptors. Auraptenol shows high inhibitory activities against larval settlement of Balanus albicostatus with EC50values of 3.38 ug m/L.
Cannabidiolic acid inhibits migration of the highly invasive MDA-MB-231 human breast cancer cells, apparently through a mechanism involving inhibition of cAMP-dependent protein kinase A, coupled with an activation of the small GTPase, RhoA. Cannabidiolic acid displays significantly greater potency at inhibiting vomiting in shrews and nausea in rats, and at enhancing 5-HT(1A) receptor activation; it also selectively inhibits cyclooxygenase (COX)-2 activity with an IC(50) value around 2 microM, has 9-fold higher selectivity than COX-1 inhibition. Cannabidiolic acid and cannabidiol have inhibitory actions on the intestines of S. murinus that are not neuronallymediated or mediated via CB1 or CB2 receptors.
Protopine acts as a potent inhibitor of thromboxane synthesis and PAF with hepatoprotective, antidepressant, antioxidant, antispasmodic and relaxant properties. Protopine is also a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines. Protopine blocks phosphorylation of mitogen-activated protein kinases (MAP kinases) and also blocks activation of a nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB).
Alpha-Yohimbine is a 5-HT1A receptor agonist, it is strong selective 2-adrenoceptor antagonist. Alpha-Yohimbine possess aphrodisiac effect.
Cannabidiol has a potent anti-arthritic effect in collagen-induced arthritis through its combined immunosuppressive and anti-inflammatory actions, it has a pharmacological profile similar to that of atypical antipsychotic drugs. Cannabidiol exerts a combination of neuroprotective, anti-oxidative and anti-apoptotic effects against beta-amyloid peptide toxicity, and that inhibition of caspase 3 appearance from its inactive precursor, pro-caspase 3, by cannabidiol is involved in the signalling pathway for this neuroprotection. Cannabidiol may have great therapeutic potential in the treatment of diabetic complications, and perhaps other cardiovascular disorders, by attenuating oxidative/ nitrative stress, inflammation, cell death and fibrosis.
Liquiritin possesses antidepressant-like, neuroprotective , antioxidant, antiapoptosis, anti-inflammatory and anti-cancer abilities. Liquiritin can attenuate advanced glycation end products-induced endothelial dysfunction via RAGE/NF-κB pathway in human umbilical vein endothelial cells, it may be a promising agent for the treatment of vasculopathy in diabetic patients.
Isoliquiritin has significant antidepressant-like, antifungal and anti-cancer activities. It induces apoptotic cell death through upregulating p53 and p21 in the A549 non-small cell lung cancer cells and inhibit the p53-dependent pathway and showed crosstalk between Akt activities.
Nicotine is a potent inhibitor of cardiac A-type K+ channels, with blockade probably due to block of closed and open channels, this action may contribute to the ability of nicotine to affect cardiac electrophysiology and induce arrhythmias.Nicotine is able to activate mitogenic signalling pathways, which promote cell growth or survival as well as increase chemoresistance of cancer cells, nicotine activates its downstream signalling to interfere with the ubiquitination process and prevent Bcl-2 from being degraded in lung cancer cells, resulting in the increase of chemoresistance.