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  • Screening Libraries
    Catharanthus roseus (L.) Don
    A unique collection of 34 Catharanthus roseus (L.) Don for high throughput screening (HTS), high content screening (HCS) and New drug research
    Catalog No. Size Price Stock
    P201491mg/well * 34 CompoundsInquiry In stock
    Contact Us
    P20149100uL/well (10mM solution) * 34 CompoundsInquiry In stock
    *You can select compounds, quantities, format (dry/solid or DMSO) and plate map to meet your specific requirement.
    Contact Us
    E-mail manager@chemfaces.com
    Tel (0086)-27-8423-7683
    Shelf Life (0086)-27-84254680
    ManufacturerWuhan ChemFaces Biochemical Co., Ltd.
    Package & Storage
    Container 96 Well Format Sample
    Storage Protected from air and light, refrigerate or freeze(2-8 °)
    Shelf Life 24 months (2-8 °)
    Intended UseFor research use only. Not for human use. Not sell to patients
    Description & Advantages
    1. The products in the ChemFaces screening libraries are all from plants.
    2. The biological activities or pharmacological activities of all the ChemFaces products are derived from the databases of all over the world the latest literatures, you can according to the product manuals on our website to access the relevant literatures, hope that our informations can give some inspirations and help to your research.
    3.The collections of unique natural products, which include antioxidants, anti-inflammatory, antibacterial, anticancer, and ect. Can be used for high throughput screening (HTS) and high content screening (HCS), is to help you carry out new drug screening, the emergence of new indications and other professional tools.
    4.Structurally diverse, medicinally active, and cell permeable, NMR and HPLC validated to ensure high purity.
    5. ChemFaces offers customized bioactive screening libraries , whereby you choose the specific compounds you want in the library, the quantities, plate map, concentration, and format (dry/solid or DMSO solution).
    Natural Products
    Catalog No. Information
    CFN99765 Catharanthine

    Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 μM, it dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes.
    CFN98083 Vindoline

    Vindoline is a chemical precursor to vinblastine and exhibits antimitotic activity by inhibiting microtubule assembly, it also has anti-ulcer activity. Vindoline can enhance the glucose-stimulated insulin secretion (GSIS) in MIN6 cells with the EC50 value of 50.2uM; it has relaxant effects in isolated rat renal arteries, it can dilate renal arteries in vitro through one or more pathways including inhibition of calcium entry,TEA+-sensitive potassium channel or protein kinase pathways in vascular smooth muscle cells.
    CFN95028 Secologanic acid

    Secologanic acid is a plant growth inhibitor, it shows inhibition of nitric oxide production in lipopolysaccharide-activated macrophages.
    CFN90467 Vinpocetine

    Vinpocetine is a selective inhibitor of voltage-sensitive sodium channel for the treatment of stroke, vascular dementia and Alzheimer's disease. Vinpocetine can attenuate neointimal formation in diabetic rats and inhibit HG-induced VSMCs proliferation, chemokinesis and apoptotic resistance by preventing ROS activation and affecting MAPK, PI3K/Akt, and NF-κB signaling.Vinpocetine has anti-inflammatory activity, can treat inflammation and pain induced by a gram-negative bacterial component by targeting NF-κB activation and NF-κB-related cytokine production in macrophages.
    CFN90464 Vincamine

    Vincamine is a plant alkaloid used clinically as a peripheral vasodilator that increases cerebral blood flow and oxygen and glucose utilization by neural tissue to combat the effect of aging. Vincamine has contractile and relaxant actions on the guinea pig trachealis, may be due to the generation of prostaglandins and to changes in the membrane Ca2+ fluxes and/or the intracellular Ca2+ distribution. Vincamine alleviates Amyloid-β 25-35 peptides-induced cytotoxicity in PC12 cells.
    CFN99208 Squalene

    Squalene, a naturally occurring substance found in plants, animals and humans, is a component of some adjuvants that is added to vaccines to enhance the immune response.Squalene shows several pharmacological properties such as hypolipidemic, hepatoprotective, cardioprotective, antioxidant, and antitoxicant activity. Squalene can significantly suppress colonic aberrant crypt foci (ACF) formation and crypt multiplicity strengthens the hypothesis that squalene possesses chemopreventive activity against colon carcinogenesis.
    CFN98916 Roseoside

    Roseoside possesses strong antioxidant properties, inhibiting lipid oxidation by 86.4, at 50 microg/mL. Roseoside has insulinotropic activity, enhances insulin release from the β-cell line INS-1.Roseoside can significantly delay carcinogenesis induced by peroxynitrite (initiator) and TPA (promoter). (6S,9R)-Roseoside also can inhibit the histamine release from rat peritoneal exudate cells induced by antigen-antibody reaction.
    CFN98901 Caboxine A

    Standard reference
    CFN98853 Vindorosine

    Vindorosine has blood vessel relaxation effect, possible underlying mechanisms involving the inhibition of Ca(2+) entry via L-type Ca(2+) channels in vascular smooth muscles.
    CFN98852 Lochnerine

    Lochnerine shows potent vasorelaxant activity, it also shows some antitumor activity, it can bring about complete inhibition of cell growth in P388 leukemia cells in vitro.