1,3,9-Trimethyluric acid | CAS:7464-93-9

1,3,9-Trimethyluric acid

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Description:

1,3,9-Trimethyluric acid exhibits in vitro cytotoxic activity against breast cancer (MCF-7), human neuroblastoma (SHSY5Y), human non-small cell lung cancer (A549) and human liver cancer (HEPG2) with IC50 value in the range of 1-3 uM. 1,3,9-Trimethyluric acid also shows promising anti-inflammatory effects in LPS induced murine macrophage J774 in vitro models in the concentration range of 100-1000 nM.

Targets:

Immunology & Inflammation related

In vitro:

Int.J.Sci. Res.,2017,6(1):13-17.

Isolation and X-ray crystal structure of 1,3,9 trimethyl purine derivative having cytotoxic activities from marine sponge Amphimedon viridis (Duchassaing & Michelotti,1864) [Reference: WebLink]

METHODS AND RESULTS:
A new purine derivative 1,3,9-Trimethyluric acid (1) was isolated from the marine sponge Amphimedon viridis and structure were confirmed by X-ray crystallography data.
CONCLUSIONS:
Compound 1 exhibited in vitro cytotoxic activity against breast cancer (MCF-7), human neuroblastoma (SHSY5Y), human non-small cell lung cancer (A549) and human liver cancer (HEPG2) with IC50 value in the range of 1-3 μM and also showed promising anti-inflammatory effects in LPS induced murine macrophage J774 in vitro models in the concentration range of 100-1000 nM.

1,3,9-Trimethyluric acid Description

Source:	The culture of the marine sponge Amphimedon viridis.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	1,3,9-Trimethyluric acid
Price:
CAS No.:	7464-93-9
Catalog No.:	CFN89099
Molecular Formula:	C₈H₁₀N₄O₃
Molecular Weight:	210.19 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The culture of the marine sponge Amphimedon viridis.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Cytotoxic Compound Library Alkaloids Compound Library Immunology & Inflammation related Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.7576 mL	23.788 mL	47.576 mL	95.152 mL	118.94 mL
5 mM	0.9515 mL	4.7576 mL	9.5152 mL	19.0304 mL	23.788 mL
10 mM	0.4758 mL	2.3788 mL	4.7576 mL	9.5152 mL	11.894 mL
50 mM	0.0952 mL	0.4758 mL	0.9515 mL	1.903 mL	2.3788 mL
100 mM	0.0476 mL	0.2379 mL	0.4758 mL	0.9515 mL	1.1894 mL

CFN90925	Guanosine	118-00-3	283.2	C₁₀H₁₃N₅O₅
CFN91545	2'-Deoxyguanosine	312693-72-4	267.2	C₁₀H₁₃N₅O₄
CFN98566	Cordycepin	73-03-0	251.24	C₁₀H₁₃N₅O₃
CFN98992	Adenosine	58-61-7	267.2	C₁₀H₁₃N₅O₄
CFN91547	2'-Deoxyadenosine	16373-93-6	251.2	C₁₀H₁₃N₅O₃
CFN93249	Inosine	58-63-9	268.2	C₁₀H₁₂N₄O₅
CFN99004	Caffeine	58-08-2	194.2	C₈H₁₀N₄O₂
CFN89099	1,3,9-Trimethyluric acid	7464-93-9	210.19	C₈H₁₀N₄O₃
CFN80067	5'-IMPdisodium salt	4691-65-0	392.17	C₁₀H₁₁N₄Na₂O₈P
CFN99524	Crotonoside	1818-71-9	283.24	C₁₀H₁₃N₅O₅