10-O-Vanilloylaucubin | CAS:193969-08-3

10-O-Vanilloylaucubin

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Description:

10-O-Vanilloylaucubin shows significant writhing inhibition following oral administration at doses of 25 mg/kg.suggests that it has analgesic effects.

In vivo:

Chem Pharm Bull (Tokyo). 1998 Apr;46(4):655-62.

Pharmacologically active components of viticis fructus (Vitex rotundifolia). II. The components having analgesic effects.[Pubmed: 9579042]

The extract of Viticis Fructus appeared to have an analgesic effect, and was subjected to activity-guided separation using acetic acid-induced writhing in mice.
METHODS AND RESULTS:
The active fraction gave new compounds, vitexfolin A (1A), B and C, 10-O-Vanilloylaucubin (3), dihydrodehydrodiconiferylalcohol-beta-D- (2'-O-p-hydroxybenzoyl)glucoside (4), and vanilloyl-beta-D-(2'O-p-hydroxybenzoyl)glucoside, together with agnuside (2) and erythro- and threoguaiacylglycerols. Compounds 1A and 2-4 showed significant writhing inhibition following oral administration at doses of 15, 50, 25, and 50 mg/kg, respectively. The effect on pressure pain threshold was tested using compounds 1A and 2 at a dose of 50 mg/kg, and only the former produced the analgesia. The analgesic effect of some related iridoid glucosides is also discussed.

10-O-Vanilloylaucubin Description

Source:	The herbs of Vitex negundo
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	10-O-Vanilloylaucubin
Price:
CAS No.:	193969-08-3
Catalog No.:	CFN99891
Molecular Formula:	C₂₃H₂₈O₁₂
Molecular Weight:	496.5 g/mol
Purity:	>=98%
Type of Compound:	Iridoids
Physical Desc.:	Powder
Source:	The herbs of Vitex negundo
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Iridoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0141 mL	10.0705 mL	20.141 mL	40.282 mL	50.3525 mL
5 mM	0.4028 mL	2.0141 mL	4.0282 mL	8.0564 mL	10.0705 mL
10 mM	0.2014 mL	1.007 mL	2.0141 mL	4.0282 mL	5.0352 mL
50 mM	0.0403 mL	0.2014 mL	0.4028 mL	0.8056 mL	1.007 mL
100 mM	0.0201 mL	0.1007 mL	0.2014 mL	0.4028 mL	0.5035 mL

CFN98530	Aucubin	479-98-1	346.33	C₁₅H₂₂O₉
CFN99031	6-O-p-Hydroxybenzoylaucubin	1016987-87-3	466.4	C₂₂H₂₆O₁₁
CFN99203	Agnuside	11027-63-7	466.4	C₂₂H₂₆O₁₁
CFN99891	10-O-Vanilloylaucubin	193969-08-3	496.5	C₂₃H₂₈O₁₂
CFN93097	Melittoside	19467-03-9	524.47	C₂₁H₃₂O₁₅
CFN90216	Rhmannioside D	81720-08-3	686.61	C₂₇H₄₂O₂₀