Soyasaponin Aa | CAS:117230-33-8 | Manufacturer ChemFaces

Soyasaponin Aa

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Description:

Soyasaponin Aa and soyasaponin Ab dose-dependently markedly inhibit adipocyte differentiation and expression of various adipogenic marker genes, through the downregulation of the adipogenesis-related transcription factors PPARγ and C/EBPα in 3T3-L1 adipocytes.

Targets:

PPAR

In vitro:

Phytother Res. 2015 Feb;29(2):281-7.

Soyasaponins Aa and Ab exert an anti-obesity effect in 3T3-L1 adipocytes through downregulation of PPARγ.[Pubmed: 25366162]

In this study, we investigated the effects and molecular mechanism of Soyasaponin Aa and soyasaponin Ab in regulating adipocyte differentiation and expression of adipogenic marker genes in 3T3-L1 adipocytes.
METHODS AND RESULTS:
Soyasaponin Aa and soyasaponin Ab dose-dependently inhibited the accumulation of lipids and the expression of adiponectin, adipocyte determination and differentiation factor 1/sterol regulatory element binding protein 1c, adipocyte fatty acid-binding protein 2, fatty acid synthase, and resistin in 3T3-L1 adipocytes. In addition, Soyasaponin Aa and soyasaponin Ab suppressed the transcriptional activity of peroxisome proliferator-activated receptor γ (PPARγ) in HEK 293T cells. Furthermore, we confirmed that the expression of PPARγ and of CCAAT-enhancer-binding protein α (C/EBPα) was suppressed at both the mRNA and protein levels in 3T3-L1 adipocytes by treatment with Soyasaponin Aa and soyasaponin Ab.
CONCLUSIONS:
Taken together, these findings indicate that Soyasaponin Aa and soyasaponin Ab markedly inhibit adipocyte differentiation and expression of various adipogenic marker genes through the downregulation of the adipogenesis-related transcription factors PPARγ and C/EBPα in 3T3-L1 adipocytes.

Soyasaponin Aa Description

Source:	The seeds of Glycine max
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Soyasaponin Aa
Price:
CAS No.:	117230-33-8
Catalog No.:	CFN90455
Molecular Formula:	C₆₄H₁₀₀O₃₁
Molecular Weight:	1365.46 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The seeds of Glycine max
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Dietary supplement Compound Library Anti-obesity Compound Library Triterpenoids Compound Library PPAR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	0.7324 mL	3.6618 mL	7.3235 mL	14.6471 mL	18.3088 mL
5 mM	0.1465 mL	0.7324 mL	1.4647 mL	2.9294 mL	3.6618 mL
10 mM	0.0732 mL	0.3662 mL	0.7324 mL	1.4647 mL	1.8309 mL
50 mM	0.0146 mL	0.0732 mL	0.1465 mL	0.2929 mL	0.3662 mL
100 mM	0.0073 mL	0.0366 mL	0.0732 mL	0.1465 mL	0.1831 mL

CFN80325	Pedunsaponin C	272120-53-3	795.0	C₄₂H₆₆O₁₄
CFN80329	Pedunsaponin A	250613-27-5	811.0	C₄₂H₆₆O₁₅
CFN90777	Soyasaponin Be methyl Ester	N/A	955.2	C₄₉H₇₈O₁₈
CFN90775	Soyasaponin Bd	135272-91-2	957.1	C₄₈H₇₆O₁₉
CFN93251	Soyasaponin IV	108906-97-4	767.0	C₄₁H₆₆O₁₃
CFN91596	Soyasaponin III	55304-02-4	796.99	C₄₂H₆₈O₁₄
CFN93159	Soyasaponin II	55319-36-3	913.1	C₄₇H₇₆O₁₇
CFN90456	Soyasaponin Bb	51330-27-9	943.12	C₄₈H₇₈O₁₈
CFN90722	Soyasaponin Ba	114590-20-4	959.1	C₄₈H₇₈O₁₉
CFN90455	Soyasaponin Aa	117230-33-8	1365.46	C₆₄H₁₀₀O₃₁