18alpha-Glycyrrhetinic acid | CAS:1449-05-4

18alpha-Glycyrrhetinic acid

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

More...

Crategolic acid

Catalog No: CFN98669
CAS No: 4373-41-5
Price: $80/20mg

6''-O-Malonylgenistin

Catalog No: CFN90631
CAS No: 51011-05-3
Price: $348/5mg

Morroniside

Catalog No: CFN98161
CAS No: 25406-64-8
Price: $50/20mg

Quercetin 3-O-neohesperidoside

Catalog No: CFN91148
CAS No: 32453-36-4
Price: $318/10mg

Ginsenoside Rh4

Catalog No: CFN92594
CAS No: 174721-08-5
Price: $368/10mg

Kaempferol 7-O-rhamnoside

Catalog No: CFN96224
CAS No: 20196-89-8
Price: $338/10mg

Cyclo(Pro-Val)

Catalog No: CFN90275
CAS No: 5654-87-5
Price: $238/10mg

Procyanidin B2

Catalog No: CFN99558
CAS No: 29106-49-8
Price: $138/20mg

Vitexin

Catalog No: CFN98601
CAS No: 3681-93-4
Price: $60/20mg

Scutellarin

Catalog No: CFN99112
CAS No: 27740-01-8
Price: $30/20mg

Description:

18alpha-Glycyrrhetinic acid has anticancer, and anti-inflammatory activities, it could significantly improve the pathological changes of CCl4-induced hepatic fibrosis.18alpha-Glycyrrhetinic acid monoglucuronide as anti-inflammatory agent through suppression of NF-κB and MAPK signaling pathway.

Targets:

NF-κB | p65 | VEGF | MMP | HMGB1 | NO | NOS | COX | NF-κB | MAPK

In vitro:

The American Journal of Physiology, 01 Jun 1999, 276(6):L1018-26.

Inhibition of gap junction communication in alveolar epithelial cells by 18alpha-glycyrrhetinic acid.[Reference: WebLink]

METHODS AND RESULTS:
Cultured alveolar epithelial cells exhibit gap junction intercellular communication (GJIC) and express regulated levels of connexin (Cx) 43 mRNA and protein. Newly synthesized radiolabeled Cx43 protein equilibrates with phosphorylated Cx43 isoforms; these species assemble to form both connexons and functional gap junction plaques. The saponin 18alpha-Glycyrrhetinic acid (GA) rapidly and reversibly blocks GJIC at low concentrations (5 microM). Extended exposure to 18alpha-GA at higher concentrations causes inhibition of GJIC and time- and dose-dependent reductions in both Cx43 protein and mRNA expression. The latter toxic effects are paralleled by disassembly of gap junction plaques and are reversed less readily than acute effects on GJIC.
CONCLUSIONS:
These observations demonstrate 18alpha-GA-sensitive regulation of intercellular communication in epithelial cells from the mammalian lung and suggest a role for Cx43 expression and phosphorylation in acute and chronic regulation of GJIC between alveolar epithelial cells.

International Journal of Oncology, 31 May 2011, 39(3):635-640.

18α-glycyrrhetinic acid targets prostate cancer cells by down-regulating inflammation-related genes.[Reference: WebLink]

Glycyrrhetinic acid is an active triterpenoid metabolite of glycyrrhizin abundantly present in licorice roots. Glycyrrhetinic acid exists as α and β stereo-isomeric forms. Both stereo-isomeric forms are known to have anti-inflammatory and anticancer activity. However, the effects and anticancer mechanism of α glycyrrhetinic acid in prostate cancer cells has not yet been evaluated.
METHODS AND RESULTS:
Therefore, we investigated the growth inhibition, induction of apoptosis and the anticancer mechanisms of 18alpha-Glycyrrhetinic acid(AGA), on the androgen-independent metastatic prostate cancer cell line DU-145. Our results showed that AGA inhibited proliferation and growth of these cells by inducing apoptosis as determined by Annexin V and flow cytometry analyses. Our studies also showed that HUVEC tube formation was drastically reduced when cultured in conditioned medium of AGA-treated DU-145 cells. In addition, AGA treatment prevented the invasion of DU-145 prostate cancer cells on matrigel coated transwells via down-regulation of NF-κB (p65), VEGF and MMP-9 expression. Furthermore, AGA treatment also down-regulated the expression of pro-inflammatory cytokine/growth factor genes HMGB1, IL-6 and IL-8 in DU-145 cells. Interestingly, AGA simultaneously upregulated the expression of non-steroidal anti-inflammatory gene-1 (NAG-1) in DU-145 cells suggesting its anti-inflammatory activity on prostate cancer cells.
CONCLUSIONS:
Taken together, the results of this study suggest that AGA may be a promising anticancer agent that merits further investigation for the chemoprevention and treatment of prostate cancer.

In vivo:

Med.chem.commun, 2017:10.1039.C7MD00210F.

18α-Glycyrrhetinic acid monoglucuronide as anti-inflammatory agent through suppression of NF-κB and MAPK signaling pathway.[Reference: WebLink]

METHODS AND RESULTS:
Based on the SAR analysis of glycyrrhizin, 18alpha-Glycyrrhetinic acid monoglucuronide (18α-GAMG) with strong inhibition against LPS-induced NO and IL-6 production in RAW264.7 cells was discovered. Western blotting and immunofluorescence results showed that 18α-GAMG reduced the expression of iNOS, COX-2, and MAPKs, as well as activation of NF-κB in the LPS-stimulated RAW264.7 cells.
CONCLUSIONS:
Further in vivo results showed that 18α-GAMG could significantly improve the pathological changes of CCl4-induced hepatic fibrosis.

18alpha-Glycyrrhetinic acid Description

Source:	The roots of Glycyrrhize glabra L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Cancer Research,2010,70(8 Supplement):573-573.

18alpha- glycyrrhetinic acid (AGA) inhibits advanced prostate cancer cell proliferation and induces apoptosis by downregulating inflammation-related cytokine growth factor genes.[Reference: WebLink]

Glycyrrhetinic acid is an active triterpenoid metabolite of glycyrrhizin abundantly present in licorice roots. Glycyr-rhetinic acid exists as α and β stereo-isomeric forms. Both stereo-isomeric forms are known to have anti-inflammatory and anticancer activity. However, the effects and anticancer mechanism of α glycyrrhetinic acid in prostate cancer cells has not yet been evaluated.
METHODS AND RESULTS:
Therefore, we investigated the growth inhibition, induction of apoptosis and the anticancer mechanisms of 18alpha-Glycyrrhetinic acid (AGA), on the androgen-independent metastatic prostate cancer cell line DU-145. Our results showed that AGA inhibited proliferation and growth of these cells by inducing apoptosis as determined by Annexin V and flow cytometry analyses. Our studies also showed that HUVEC tube formation was drastically reduced when cultured in conditioned medium of AGA-treated DU-145 cells. In addition, AGA treatment prevented the invasion of DU-145 prostate cancer cells on matrigel coated transwells via down-regulation of NF-κB (p65), VEGF and MMP-9 expression. Furthermore, AGA treatment also down-regulated the expression of pro-inflammatory cytokine/growth factor genes HMGB1, IL-6 and IL-8 in DU-145 cells. Interestingly, AGA simultaneously upregulated the expression of non-steroidal anti-inflammatory gene-1 (NAG-1) in DU-145 cells suggesting its anti-inflammatory activity on prostate cancer cells.
CONCLUSIONS:
Taken together, the results of this study suggest that AGA may be a promising anticancer agent that merits further investigation for the chemoprevention and treatment of prostate cancer.

Product Name	18alpha-Glycyrrhetinic acid
Price:
CAS No.:	1449-05-4
Catalog No.:	CFN70274
Molecular Formula:	C₃₀H₄₆O₄
Molecular Weight:	470.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The roots of Glycyrrhize glabra L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Triterpenoids Compound Library p65 Inhibitor Library NOS Inhibitor Library NO Inhibitor Library MAPK Inhibitor Library COX Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1245 mL	10.6225 mL	21.245 mL	42.4899 mL	53.1124 mL
5 mM	0.4249 mL	2.1245 mL	4.249 mL	8.498 mL	10.6225 mL
10 mM	0.2124 mL	1.0622 mL	2.1245 mL	4.249 mL	5.3112 mL
50 mM	0.0425 mL	0.2124 mL	0.4249 mL	0.8498 mL	1.0622 mL
100 mM	0.0212 mL	0.1062 mL	0.2124 mL	0.4249 mL	0.5311 mL

CFN96026	Obtucarbamate B	20913-18-2	238.2	C₁₁H₁₄N₂O₄
CFN89405	(-)-Heraclenol	139079-42-8	304.29	C₁₆H₁₆O₆
CFN92163	Salviolone	119400-86-1	268.4	C₁₈H₂₀O₂
CFN95603	Germanaism C	696663-52-2	684.6	C₃₀H₃₆O₁₈