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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $290.7 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
J Sep Sci.2018, 41(11):2488-2497Pharmacol Res.2022, 182:106346.LWT2020, 130:109535Phytochem Anal.2021, 32(6):970-981.Molecules.2021, 26(4):1084.Evid Based Complement Alternat Me...2020...Appl Microbiol Biotechnol....2018...Molecules.2021, 26(16):4722.
Processes2021, 9(5),831.Biochem Biophys Res Commun....2018...Biochem Biophys Res Commun....2020...Org Biomol Chem.2017, 15(31):6483-6492Natural Product Communications...2021...Food Sci Nutr.2019, 8(1):246-256Molecules.2021, 26(6):1635. Evid Based Complement Alternat Me...2017...
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John Innes Centre (United Kingdom)The University of Newcastle (Australia)University of British Columbia (Canada)
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Ginsenoside Rh4
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+86-27-84254680
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Molecules.2019, 24(16):E2985Natural Product Communications2021, 16(9):1-10.Molecules.2022, 27(2):451.Analytical sci. & Tech2020, 33(5):224-231Industrial Crops and Products2022, 188:115638Food and Fermentation Industries2019, 45(7):45-51J Nat Prod.2018, 81(4):966-975Invest New Drugs.2017, 35(2):166-179J Pain Res.2022, 15:3469-3478.Phytomedicine.2019, 67:153159
Related Screening Libraries
| Description: |
Ginsenoside Rh4 is a rare saponin obtained from Panax notoginseng. Ginsenoside Rh4 activates Bax, caspase 3, caspase 8, and caspase 9. Ginsenoside Rh4 also induces autophagy. Ginsenoside Rh4 could be safely used as adjuvant with low or non-haemolytic effect; it has cytotoxic activity and its aglycone against cancer cell lines. |
| Targets: |
Caspase | Autophagy | Bcl-2/Bax |
| In vivo: |
| Chem Biodivers. 2007 Feb;4(2):232-40. | | Immunological adjuvant effect of ginsenoside Rh4 from the roots of Panax notoginseng on specific antibody and cellular response to ovalbumin in mice.[Pubmed: 17311234] |
METHODS AND RESULTS:
Ginsenoside Rh4 (1), a saponin isolated from the roots of Panax notoginseng (Burk.) F. H. Chen, was evaluated for its haemolytic activity and adjuvant potential on specific antibody and cellular response to ovalbumin (OVA) in mice. Compound 1 showed a slight haemolytic effect, its concentration inducing 50% of the maximum haemolysis (HD(50) value) being 407+/-12 microg/ml using a 0.5% suspension of red blood cells. Ginsenoside Rh4 significantly increased the concanavalin A (Con A)-, lipopolysaccharide (LPS)-, and OVA-induced splenocyte proliferation in OVA-immunized mice especially at a dose of 25 microg (P<0.05, P<0.01, or P<0.001). The OVA-specific serum IgG, IgG1, and IgG2b antibody levels were also significantly enhanced by 1 at a dose of 25 microg compared to the OVA control group (P<0.05 or P<0.01). Moreover, the enhancing effect of Ginsenoside Rh4 on the OVA-specific IgG2b antibody responses to OVA in mice was more significant than that of Alum (Al(OH)(3) gel; P<0.01).
CONCLUSIONS:
These results suggest that Ginsenoside Rh4 could be safely used as adjuvant with low or non-haemolytic effect. |
|
Ginsenoside Rh4 Description
| Source: |
The roots of Panax ginseng C. A. Mey. |
| Solvent: |
DMSO, Pyridine, Methanol, Ethanol, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.6106 mL |
8.0528 mL |
16.1057 mL |
32.2113 mL |
40.2641 mL |
| 5 mM |
0.3221 mL |
1.6106 mL |
3.2211 mL |
6.4423 mL |
8.0528 mL |
| 10 mM |
0.1611 mL |
0.8053 mL |
1.6106 mL |
3.2211 mL |
4.0264 mL |
| 50 mM |
0.0322 mL |
0.1611 mL |
0.3221 mL |
0.6442 mL |
0.8053 mL |
| 100 mM |
0.0161 mL |
0.0805 mL |
0.1611 mL |
0.3221 mL |
0.4026 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Structure Identification: |
| Planta Med. 1996 Feb;62(1):86-7. | | Ginsenoside Rh4, a genuine dammarane glycoside from Korean red ginseng.[Pubmed: 8720394] |
METHODS AND RESULTS:
A genuine glycoside, named Ginsenoside Rh4, was isolated from Korean red ginseng (Panax ginseng C. A. Meyer) through repeated column chromatography, and its chemical structure was established to be 6-O-beta-D-glucopyranosyldammar-20(22),24-diene-3 beta,6 alpha,12 beta-triol by spectral and chemical methods. The stereochemistry of a double bond at C-20(22) of Ginsenoside Rh4 was characterized as (E) from a NOESY experiment in the 1H-NMR of the aglycone.
CONCLUSIONS:
Cytotoxic activities of Ginsenoside Rh4 and its aglycone against cancer cell lines were evaluated by use of the SRB method. |
|
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