Ginsenoside Rh4 | CAS:174721-08-5 | Manufacturer ChemFaces

Ginsenoside Rh4

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Description:

Ginsenoside Rh4 is a rare saponin obtained from Panax notoginseng. Ginsenoside Rh4 activates Bax, caspase 3, caspase 8, and caspase 9. Ginsenoside Rh4 also induces autophagy. Ginsenoside Rh4 could be safely used as adjuvant with low or non-haemolytic effect; it has cytotoxic activity and its aglycone against cancer cell lines.

Targets:

Caspase | Autophagy | Bcl-2/Bax

In vivo:

Chem Biodivers. 2007 Feb;4(2):232-40.

Immunological adjuvant effect of ginsenoside Rh4 from the roots of Panax notoginseng on specific antibody and cellular response to ovalbumin in mice.[Pubmed: 17311234]

METHODS AND RESULTS:
Ginsenoside Rh4 (1), a saponin isolated from the roots of Panax notoginseng (Burk.) F. H. Chen, was evaluated for its haemolytic activity and adjuvant potential on specific antibody and cellular response to ovalbumin (OVA) in mice. Compound 1 showed a slight haemolytic effect, its concentration inducing 50% of the maximum haemolysis (HD(50) value) being 407+/-12 microg/ml using a 0.5% suspension of red blood cells. Ginsenoside Rh4 significantly increased the concanavalin A (Con A)-, lipopolysaccharide (LPS)-, and OVA-induced splenocyte proliferation in OVA-immunized mice especially at a dose of 25 microg (P<0.05, P<0.01, or P<0.001). The OVA-specific serum IgG, IgG1, and IgG2b antibody levels were also significantly enhanced by 1 at a dose of 25 microg compared to the OVA control group (P<0.05 or P<0.01). Moreover, the enhancing effect of Ginsenoside Rh4 on the OVA-specific IgG2b antibody responses to OVA in mice was more significant than that of Alum (Al(OH)(3) gel; P<0.01).
CONCLUSIONS:
These results suggest that Ginsenoside Rh4 could be safely used as adjuvant with low or non-haemolytic effect.

Ginsenoside Rh4 Description

Source:	The roots of Panax ginseng C. A. Mey.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Structure Identification:

Planta Med. 1996 Feb;62(1):86-7.

Ginsenoside Rh4, a genuine dammarane glycoside from Korean red ginseng.[Pubmed: 8720394]

METHODS AND RESULTS:
A genuine glycoside, named Ginsenoside Rh4, was isolated from Korean red ginseng (Panax ginseng C. A. Meyer) through repeated column chromatography, and its chemical structure was established to be 6-O-beta-D-glucopyranosyldammar-20(22),24-diene-3 beta,6 alpha,12 beta-triol by spectral and chemical methods. The stereochemistry of a double bond at C-20(22) of Ginsenoside Rh4 was characterized as (E) from a NOESY experiment in the 1H-NMR of the aglycone.
CONCLUSIONS:
Cytotoxic activities of Ginsenoside Rh4 and its aglycone against cancer cell lines were evaluated by use of the SRB method.

CAS No.	174721-08-5	Price	$368 / 10mg
Catalog No.	CFN92594	Purity	>=98%
Molecular Weight	620.9	Type of Compound	Triterpenoids
Formula	C₃₆H₆₀O₈	Physical Description	Powder
Download	Manual COA MSDS SDF	Similar structural	Comparison (Web) (SDF)

Product Name	Ginsenoside Rh4
CAS No.:	174721-08-5
Catalog No.:	CFN92594
Molecular Formula:	C₃₆H₆₀O₈
Molecular Weight:	620.9 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Targets:	Caspase \| Autophagy \| Bcl-2/Bax
Source:	The roots of Panax ginseng C. A. Mey.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Price:	$368 / 10mg

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Hemolytic Compound Library Nephroprotective Compound Library Triterpenoids Compound Library Caspase Inhibitor Library Bcl-2/Bax Inhibitor Library Autophagy Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6106 mL	8.0528 mL	16.1057 mL	32.2113 mL	40.2641 mL
5 mM	0.3221 mL	1.6106 mL	3.2211 mL	6.4423 mL	8.0528 mL
10 mM	0.1611 mL	0.8053 mL	1.6106 mL	3.2211 mL	4.0264 mL
50 mM	0.0322 mL	0.1611 mL	0.3221 mL	0.6442 mL	0.8053 mL
100 mM	0.0161 mL	0.0805 mL	0.1611 mL	0.3221 mL	0.4026 mL

CFN92594	Ginsenoside Rh4	174721-08-5	620.9	C₃₆H₆₀O₈
CFN90572	Ginsenoside Rg4	126223-28-7	767.0	C₄₂H₇₀O₁₂
CFN99477	3-Acetoxy-24-hydroxydammara-20,25-diene	143519-04-4	484.8	C₃₂H₅₂O₃
CFN92818	Ginsenoside Rk2	364779-14-6	604.9	C₃₆H₆₀O₇
CFN92644	Ginsenoside Rk1	494753-69-4	767.0	C₄₂H₇₀O₁₂
CFN99972	Ginsenoside Rh3	105558-26-7	604.86	C₃₆H₆₀O₇
CFN92643	Ginsenoside Rg5	186763-78-0	767.0	C₄₂H₇₀O₁₂
CFN91838	Damulin A	1202868-74-3	783.0	C₄₂H₇₀O₁₃
CFN91837	Damulin B	1202868-75-4	783.0	C₄₂H₇₀O₁₃
CFN92593	Ginsenoside Rk3	364779-15-7	620.9	C₃₆H₆₀O₈