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2,3-Dihydro-3-methoxywithaferin A
2,3-Dihydro-3-methoxywithaferin A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name 2,3-Dihydro-3-methoxywithaferin A
Price:
CAS No.: 21902-96-5
Catalog No.: CFN92965
Molecular Formula: C29H42O7
Molecular Weight: 502.64 g/mol
Purity: >=98%
Type of Compound: Steroids
Physical Desc.: Powder
Source: The herbs of Physali alkekengi.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: 2,3-Dihydro-3-methoxywithaferin A is a natural withanolide , is cytotoxic to human cancer cells, and is a candidate anticancer natural compound. It protects normal cells against stress.
Targets: Akt | MAPK
In vitro:
J Nat Prod. 2017 Oct 27;80(10):2756-2760.
2,3-Dihydro-3β-methoxy Withaferin-A Protects Normal Cells against Stress: Molecular Evidence of Its Potent Cytoprotective Activity.[Pubmed: 29043807]
2,3-Dihydro-3β-methoxy withaferin-A (2,3-Dihydro-3-methoxywithaferin A,3βmWi-A) is a natural withanolide that is structurally close to withaferin-A (Wi-A), is cytotoxic to human cancer cells, and is a candidate anticancer natural compound.
METHODS AND RESULTS:
Using cell-based biochemical, molecular, and imaging assays, we report that Wi-A and 3βmWi-A possess contrasting activities. Whereas Wi-A caused oxidative stress to normal cells, 3βmWi-A was well tolerated at even 10-fold higher concentrations. Furthermore, it promoted survival and protected normal cells against oxidative, UV radiation, and chemical stresses. We provide molecular evidence that 3βmWi-A induces antistress and pro-survival signaling through activation of the pAkt/MAPK pathway.
CONCLUSIONS:
We demonstrate that 3βmWi-A (i) contrary to Wi-A is safe and possesses stress-relieving activity, (ii) when given subsequent to a variety of stress factors including Wi-A, protects normal cells against their toxicity, and (iii) is a vital compound that may guard normal cells against the toxicity associated with various targeted therapeutic regimes in clinical practice.
2,3-Dihydro-3-methoxywithaferin A Description
Source: The herbs of Physali alkekengi.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.9895 mL 9.9475 mL 19.895 mL 39.7899 mL 49.7374 mL
5 mM 0.3979 mL 1.9895 mL 3.979 mL 7.958 mL 9.9475 mL
10 mM 0.1989 mL 0.9947 mL 1.9895 mL 3.979 mL 4.9737 mL
50 mM 0.0398 mL 0.1989 mL 0.3979 mL 0.7958 mL 0.9947 mL
100 mM 0.0199 mL 0.0995 mL 0.1989 mL 0.3979 mL 0.4974 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Quercetin-3-O-sophoroside

Catalog No: CFN90630
CAS No: 18609-17-1
Price: $80/20mg
Cauloside A

Catalog No: CFN96440
CAS No: 17184-21-3
Price: $318/10mg
Tenuifolin

Catalog No: CFN98157
CAS No: 20183-47-5
Price: $100/20mg
Schaftoside

Catalog No: CFN90197
CAS No: 51938-32-0
Price: $80/20mg
Astragaloside IV

Catalog No: CFN99171
CAS No: 84687-43-4
Price: $30/20mg
Ginsenoside Rg5

Catalog No: CFN92643
CAS No: 186763-78-0
Price: $168/10mg
Ononin

Catalog No: CFN99136
CAS No: 486-62-4
Price: $50/20mg
Phlorizin

Catalog No: CFN97038
CAS No: 60-81-1
Price: $30/20mg
Bacopaside II

Catalog No: CFN93234
CAS No: 382146-66-9
Price: $288/10mg
Soyasapogenol C

Catalog No: CFN91068
CAS No: 595-14-2
Price: $463/5mg
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