ChemFaces is a professional high-purity natural products manufacturer.
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2. Pharmacological research
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $11.8 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
J. of Med. Plant Research.2013, 90-151BMC Complement Altern Med.2014, 14:242Mol Med Rep.2015, 12(5):7789-95Int J Mol Sci.2015, 16(1):1232-51Evid Based Complement Alternat Me...2015...Pharm Biol.2016, 54(7):1255-62Universidade Estadual Paulista...2017...Sci Rep. 2017, 12953(7)
J Ethnopharmacol.2017, 206:73-77J Ethnopharmacol.2017, 209:305-316Mol Cell.2017, 68(4):673-685Sci Rep.2017, 7:40345Food Res Int.2017, 96:40-45J of Engineering Science&Technolo...2018...Evid Based Complement Alternat Me...2018...Chemistry of Natural Compounds...2018...
J Med Food.2019, 22(10):1067-1077Saudi Pharm J.2019, 27(1):145-153Sci Rep.2020, 10:4495(2020)Evid Based Complement Alternat Me...2020...Int J Mol Sci.2020, 21(22):8816. Molecules.2020, 25(20):4851.J of Food Quality2020, 8851285.
Our products had been exported to the following research institutions and universities, And still growing.
University of Canterbury (New Zealand)Helmholtz Zentrum München (Germany)Shanghai Institute of Organic C... (China)University of Virginia (USA)
University of Ioannina (Greece)National Research Council of Ca... (Canada)Uniwersytet Gdański (Poland)Kazusa DNA Research Institute (Japan)
University of Pretoria (South Africa)Universite de Lille1 (France)University of Illinois at Chicago (USA)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Molecules.2020, 25(18):4283.Scientific World Journal.2014, 2014:654193PLoS One.2018, 13(11):e0208055Appl. Sci.2020, 10(5),1713.Saf Health Work.2019, 10(2):196-204Analytical methods2019, 11(6)Food Chem.2020, 313:126079Chinese Pharmacological Bulletin2019, 35(8):1120-1125J Ethnopharmacol.2020, 269:113752. Phytother Res.2019, 33(5):1490-1500
Related Screening Libraries
||Piceatannol has antitumor, antioxidant, and anti-inflammatory activities, it also has the potential to control obesity. Piceatannol inhibits effector T cell functions by suppressing TcR signaling. |
||IL Receptor | ERK | Akt | p38MAPK | gp120/CD4|
|Int Immunopharmacol. 2015 Feb 9;25(2):285-292. |
|Piceatannol inhibits effector T cell functions by suppressing TcR signaling.[Pubmed: 25676533]|
|Piceatannol, a metabolite of resveratrol found in red wine and grapes, displays a wide spectrum of biological activity. Although the anti-oxidant, anti-inflammatory, and anti-tumorigenesis activity of Piceatannol has been extensively studied, its role in the adaptive immune response has received less attention.|
METHODS AND RESULTS:
Here we investigated the role of Piceatannol, a well-known Syk inhibitor, in T cell activation, proliferation, and differentiation using isolated murine splenic T cells from C57BL/6 mice. Piceatannol treatment inhibited surface expression of CD4 and CD8 T cell activation markers CD25 and CD69, reduced production of cytokines IFNγ, IL-2, and IL-17, and suppressed proliferation of activated T cells. Moreover, Piceatannol treatment significantly inhibited differentiation of CD4(+)CD25(-)CD62L(+) naïve CD4 T cells into Th1, Th2, and Th17 cells, presumably due to inhibition of TcR signaling through p-Erk, p-Akt, and p-p38.
Piceatannol appears to be a useful nutritional or pharmacological biomolecule that regulates effector T cell functions such as cytokine production, differentiation, and proliferation.
|Phytother Res. 2014 Nov;28(11):1581-8. |
|A review of the pharmacological effects of piceatannol on cardiovascular diseases.[Pubmed: 24919577]|
|The incidence of cardiovascular diseases (CVDs) is high in both developed and developing countries. It has a high global rate of mortality and causes heavy social burden. Drugs are available for managing or treating CVDs and its complications. Consumption of dietary supplements or functional foods for reducing the risk of CVDs has also gained wide recognition by the general public. |
METHODS AND RESULTS:
Piceatannol, an analog and metabolite of resveratrol, is a natural stilbene commonly found in the skin of grapes and wine. Piceatannol is believed to be a potent compound with certain cardiovascular therapeutic effects, such as the prevention of hypercholesterolemia, arrhythmia, atherosclerosis, and angiogenesis. It also has vasorelaxation and antioxidant activities.
A comprehensive review of Piceatannol concludes that Piceatannol has the potential to be developed into health products for the cardiovascular system to help modern society reduce the high CVD incidence. However, further investigations are warranted in order to increase the bioavailability and understand the biological mechanisms and safety of using Piceatannol.
||The rhizomes of Polygonum cuspidatum Sieb. et Zucc.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Anticancer Agents Med Chem. 2015;15(2):248-57. |
|Toxic Effects of Aflatoxin B1 on Embryonic Development of Zebrafish (Danio rerio): Potential Activity of Piceatannol Encapsulated Chitosan/poly (Lactic Acid) Nanoparticles.[Pubmed: 25322988]|
|The aim was to analyse the efficacy of Piceatannol (PIC) loaded chitosan (CS)/poly(lactic acid)(PLA) nanoparticles (CS/PLA-PIC NPs) in zebra fish embryos exposed to aflatoxin B1 (AFB1). |
METHODS AND RESULTS:
FTIR confirmed the chemical interaction between the polymers and drug. SEM showed the size of CS/PLA-PIC NPs approximately 87 to 200nm, compared to CS-PLA NPs of 150nm size. The size was further affirmed as 127nm (CS-PLA NPs) and 147nm (CS/PLA-PIC NPs) by zetasizer depiction. CS/PLA-PIC NPs have not illustrated toxicity at high concentrations when tested in zebrafish embryos. AFB1 wielded their toxic effects on the survival, spontaneous movement, hatching and heart rate and development of embryos were observed in both time and dose-dependent manner at 4μM.
Our results suggested that the addition of CS/PLA-PIC NPs increases the survival, heart rate and hatching in time dependent manner at the dosage of 20μg/ml. These hopeful results may prompt the advancement of drug encapsulated polymeric nanoparticles which may have the potential role in improving the AFB1 induced toxicity in humans as well.