Info: Read More
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • How to Order
  • Delivery time
  • Science | Nature | Cell | View More
    Natural Products
    2,4,6-Trihydroxybenzaldehyde
    2,4,6-Trihydroxybenzaldehyde
    Information
    CAS No. 487-70-7 Price $30 / 20mg
    Catalog No.CFN70120Purity>=98%
    Molecular Weight154.1Type of CompoundPhenols
    FormulaC7H6O4Physical DescriptionPowder
    Download COA    MSDSSimilar structuralComparison
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $7.0 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • University of Eastern Finland (Finland)
  • Tohoku University (Japan)
  • Chang Gung University (Taiwan)
  • Sanford Burnham Medical Researc... (USA)
  • University of Vigo (Spain)
  • Kyung Hee University (Korea)
  • Agricultural Research Organizat... (Israel)
  • Sri Ramachandra University (India)
  • University of Beira Interior (Portugal)
  • Universidade de Franca (Brazil)
  • Colorado State University (USA)
  • More...
  • Package
    Featured Products
    Quercetin-3-O-glucuronide

    Catalog No: CFN92172
    CAS No: 22688-79-5
    Price: $298/20mg
    Ginsenoside Re

    Catalog No: CFN99974
    CAS No: 52286-59-6
    Price: $40/20mg
    Isonemerosin

    Catalog No: CFN95008
    CAS No: 181524-79-8
    Price: $268/20mg
    3-O-Feruloylquinic acid

    Catalog No: CFN92393
    CAS No: 1899-29-2
    Price: $/mg
    Mulberroside F

    Catalog No: CFN90794
    CAS No: 193483-95-3
    Price: $288/10mg
    3-O-Caffeoylquinic acid methyl ester

    Catalog No: CFN92573
    CAS No: 123483-19-2
    Price: $198/10mg
    Kurarinone

    Catalog No: CFN92003
    CAS No: 34981-26-5
    Price: $118/20mg

    2,4,6-Trihydroxybenzaldehyde

    2,4,6-Trihydroxybenzaldehyde
    Product Name 2,4,6-Trihydroxybenzaldehyde
    CAS No.: 487-70-7
    Catalog No.: CFN70120
    Molecular Formula: C7H6O4
    Molecular Weight: 154.1 g/mol
    Purity: >=98%
    Type of Compound: Phenols
    Physical Desc.: Powder
    Targets: 伪-glucosidase | NF-ĸB | C/EBP伪 | PPAR纬 | FAS
    Source: The fruits of Aronia melanocarpa Elliot.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $30 / 20mg
    Download: COA    MSDS
    Similar structural: Comparison
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    Address:
    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1113:1-13
  • Cancers (Basel).2023, 15(1):293.
  • Cell.2018, 172(1-2):249-261
  • BMC Plant Biol.2021, 21(1):60.
  • J Food Sci Technol.2022, 59(1):212-219.
  • Foods.2022, 11(12):1708.
  • Horticulturae2022, 8(10), 975.
  • Molecules.2019, 24(10):E1926
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • JPC-Journal of Planar Chromatography 2017, 30(4)
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Phenols Compound Library
  • FAS Inhibitor Library
  • Biological Activity
    Description: 2,4,6-Trihydroxybenzaldehyde, a potential anti-obesity treatment, suppressed adipocyte differentiation in 3T3-L1 cells and fat accumulation induced by high-fat diet in C57BL/6 mice. It is also as a potent antidiabetic agent alleviates postprandial hyperglycemia in normal and diabetic rats. 2,4,6-Trihydroxybenzaldehyde has potential anticancer activity. 2,4,6-trihydroxybenzaldehyde shows strong noncompetitive α-glucosidase inhibition (IC50 = 4.60 μM) and powerful antioxidant activity (DPPH assay) (IC50 = 71.4 μM) in vitro.
    Targets: α-glucosidase | NF-ĸB | C/EBPα | PPARγ | FAS
    In vitro:
    Anticancer research,2016,36(11):5743-5750.
    Vanillin Analogues o-Vanillin and 2,4,6-Trihydroxybenzaldehyde Inhibit NFĸB Activation and Suppress Growth of A375 Human Melanoma.[Reference: WebLink]
    Constitutive activation of nuclear factor kappa-B (NFĸB) is a hallmark of various cancer types, including melanoma. Chemotherapy may further increase tumour NFĸB activity, a phenomenon that, in turn, exacerbates drug resistance. This study aimed at preliminary screening of a panel of aromatic aldehydes, including vanillin, for cytotoxicity and suppression of tumour cell NFĸB activity.
    METHODS AND RESULTS:
    The cytotoxic and NFĸB-inhibitory effects of 10 aromatic aldehydes, including vanillin, were investigated in cultured A375 human melanoma cells. Each compound was assayed alone and in combination with the model NFĸB-activating drug doxorubicin. The most promising analogues were then tested alone and in combination with 4-hydroperoxycyclophosphamide in vitro, and with cyclophosphamide in mice bearing A375 xenografts. The vanillin analogues o-vanillin and 2,4,6-Trihydroxybenzaldehyde exhibited cytotoxicity against cultured A375 cells, and inhibited doxorubicin- and 4-hydroperoxycyclophosphamide-induced NFĸB activation. They also suppressed A375 cell growth in mice.
    CONCLUSIONS:
    o-vanillin and 2,4,6-Trihydroxybenzaldehyde deserve further evaluation as potential anticancer drugs.
    2,4,6-Trihydroxybenzaldehyde Description
    Source: The fruits of Aronia melanocarpa Elliot.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds
    Maculosidin

    Catalog No: CFN95126
    CAS No: 522-19-0
    Price: $413/5mg
    Cannabiscitrin

    Catalog No: CFN95278
    CAS No: 520-14-9
    Price: $318/5mg
    3'-Angeloyloxy-4'-senecioyloxy-2',...

    Catalog No: CFN95123
    CAS No: 1221686-60-7
    Price: $398/5mg
    Epimedin B1

    Catalog No: CFN95017
    CAS No: 133137-58-3
    Price: $268/5mg
    Caraganaphenol A

    Catalog No: CFN95093
    CAS No: 174916-31-5
    Price: $333/5mg
    15-Methoxy-16-oxo-15,16H-strictic ...

    Catalog No: CFN95261
    CAS No: 1356388-38-9
    Price: $368/5mg
    Protocatechuic acid 4-O-beta-gluco...

    Catalog No: CFN95557
    CAS No: 7361-59-3
    Price: $413/5mg
    Epischisandrone

    Catalog No: CFN95212
    CAS No: 98619-26-2
    Price: $413/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.4893 mL 32.4465 mL 64.8929 mL 129.7859 mL 162.2323 mL
    5 mM 1.2979 mL 6.4893 mL 12.9786 mL 25.9572 mL 32.4465 mL
    10 mM 0.6489 mL 3.2446 mL 6.4893 mL 12.9786 mL 16.2232 mL
    50 mM 0.1298 mL 0.6489 mL 1.2979 mL 2.5957 mL 3.2446 mL
    100 mM 0.0649 mL 0.3245 mL 0.6489 mL 1.2979 mL 1.6223 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Kinase Assay:
    Medicinal Chemistry Research, 2010, 20(8):1181-1187.
    2,4,6-Trihydroxybenzaldehyde as a potent antidiabetic agent alleviates postprandial hyperglycemia in normal and diabetic rats.[Reference: WebLink]

    METHODS AND RESULTS:
    Five distinct organic compounds with protected and unprotected phenolic hydroxyl groups were screened for their α-glucosidase inhibitory potential. Of these compounds, 2,4,6-Trihydroxybenzaldehyde (THB) showed the strongest noncompetitive α-glucosidase inhibition (IC50 = 4.60 μM) and the most powerful antioxidant activity (DPPH assay) (IC50 = 71.4 μM) in vitro.
    CONCLUSIONS:
    In in vivo studies, THB significantly reduced blood glucose levels in normal and diabetic rats after glucose load compared to maltose load.
    Cell Research:
    J Agric Food Chem, 2010, 58(9):5320-5327.
    Gut metabolites of anthocyanins, gallic acid, 3-O-methylgallic acid, and 2,4,6-trihydroxybenzaldehyde, inhibit cell proliferation of Caco-2 cells.[Pubmed: 20373763]
    Gut microflora metabolize anthocyanins to phenolic acids and aldehydes. These metabolites may explain the relationship between anthocyanin consumption and reduced incidence of colon cancer.
    METHODS AND RESULTS:
    Here, all six major metabolites, along with a Cabernet Sauvignon anthocyanin extract, were incubated with Caco-2 cells at concentrations of 0-1000 microM over 72 h to determine effects on cell proliferation and for 24 h to assess cytotoxicity effects and at 140 microM for 24 h to measure induction of apoptosis. These measurements were based on colorimetric methods. Gallic acid and 3-O-methylgallic acid inhibited cell proliferation and lacked cytotoxicity at low concentrations. The aldehyde metabolite and anthocyanin extract also inhibited cell proliferation at low concentrations and had low cytotoxicity at a wide range of concentrations. Of the four substances that effectively reduced cell proliferation, the aldehyde was the best inducer of apoptosis. In addition, these same four treatments degraded quickly in growth media, suggesting the involvement of subsequent oxidation products in the reduction of cell viability.
    CONCLUSIONS:
    These results indicate that the anthocyanin microfloral metabolites gallic acid, 3-O-methylgallic acid, and 2,4,6-Trihydroxybenzaldehyde reduce cell proliferation in Caco-2 cells more effectively than anthocyanins and may offer protection against colon cancer after their formation in the gut.
    Animal Research:
    Environmental Toxicology and Pharmacology, 2015,39(2):962-968.
    2,4,6-Trihydroxybenzaldehyde, a potential anti-obesity treatment, suppressed adipocyte differentiation in 3T3-L1 cells and fat accumulation induced by high-fat diet in C57BL/6 mice .[Reference: WebLink]

    METHODS AND RESULTS:
    In the present study, 2,4,6-Trihydroxybenzaldehyde (THB) was evaluated for inhibitory effects on adipocyte differentiation in 3T3-L1 cells and anti-obesity effects in mice with high-fat diet (HFD)-induced obesity. Lipid accumulation measurement indicated that THB markedly inhibited adipogenesis, and this involved down-regulation of the expression of the adipogenesis-related proteins, CCAAT/enhancer-binding protein α (C/EBPα), peroxisome proliferator-activated receptor γ (PPARγ), fatty acid synthase (FAS) and sterol regulatory element-binding protein-1c (SREBP-1c), in 3T3-L1 pre-adipocyte cells. In a mouse model of HFD-induced obesity, oral administration of THB (5 and 25 mg/kg for 13 weeks) reduced the HFD-induced increase in weight gain. THB administration also reduced serum levels of glucose, triglycerides, and total cholesterol. A reduction in the hypertrophy of white adipose tissue was also observed. Furthermore, THB administration inhibited HFD-induced hepatic steatosis.
    CONCLUSIONS:
    These results provided evidence that administration of THB alleviated HFD-induced obesity in C57BL/6 mice and revealed the potential of THB as a nutraceutical to help prevent or treat obesity and the associated metabolic disorders.
    Quercetin-3-O-glucuronide

    Catalog No: CFN92172
    CAS No: 22688-79-5
    Price: $298/20mg
    Ginsenoside Re

    Catalog No: CFN99974
    CAS No: 52286-59-6
    Price: $40/20mg
    Isonemerosin

    Catalog No: CFN95008
    CAS No: 181524-79-8
    Price: $268/20mg
    3-O-Feruloylquinic acid

    Catalog No: CFN92393
    CAS No: 1899-29-2
    Price: $/mg
    Mulberroside F

    Catalog No: CFN90794
    CAS No: 193483-95-3
    Price: $288/10mg
    3-O-Caffeoylquinic acid methyl ester

    Catalog No: CFN92573
    CAS No: 123483-19-2
    Price: $198/10mg
    Kurarinone

    Catalog No: CFN92003
    CAS No: 34981-26-5
    Price: $118/20mg
    Tags: buy 2,4,6-Trihydroxybenzaldehyde | 2,4,6-Trihydroxybenzaldehyde supplier | purchase 2,4,6-Trihydroxybenzaldehyde | 2,4,6-Trihydroxybenzaldehyde cost | 2,4,6-Trihydroxybenzaldehyde manufacturer | order 2,4,6-Trihydroxybenzaldehyde | 2,4,6-Trihydroxybenzaldehyde distributor