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    Natural Products
    Glaucoside A
    Glaucoside A
    Information
    CAS No. 81474-91-1 Price $318 / 5mg
    Catalog No.CFN95299Purity>=98%
    Molecular Weight520.2Type of CompoundSteroids
    FormulaC28H40O9Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $365.7 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Glaucoside A

    Glaucoside A
    Product Name Glaucoside A
    CAS No.: 81474-91-1
    Catalog No.: CFN95299
    Molecular Formula: C28H40O9
    Molecular Weight: 520.2 g/mol
    Purity: >=98%
    Type of Compound: Steroids
    Physical Desc.: Powder
    Source: The roots of Cynanchum stauntonii
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price: $318 / 5mg
    Inquire / Order: manager@chemfaces.com
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
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  • Biological Activity
    Description: Anticancer. Glaucoside A was evaluated against the HT-29 and HCT 116 human colon cancer cell lines.
    In vitro:
    Indian J Pharmacol . Jan-Feb 2016;48(1):99-100.
    Cytotoxic activity of a glaucoside from Eugenia jambolana against MCF-7 cells[Pubmed: 26997737]
    Magn Reson Chem . 2011 Feb;49(2):83-9
    Glaucasides A-C, three saikosaponins from Atriplex glauca L. var. ifiniensis (Caball) Maire[Pubmed: 21254229]
    From the roots of Atriplex glauca L. var. ifiniensis (Caball) Maire (syn. of Atriplex parvifolia Lowe var. genuina Maire), three new saikosaponins designated as glaucasides A-C (1-3) were isolated together with the known 3-O-β-D-glucopyranosyl-(1 → 2)-β-D-galactopyranosyl-saikogenin F (4). The structures of the new compounds were elucidated by extensive analysis of one-dimensional and two-dimensional NMR spectroscopy, FABMS, HR-ESIMS and chemical evidence as 13β,28-epoxy-16β,21β-dihydroxyolean-11-en-3β-yl O-β-D-[2-O-sulfate]-glucopyranosyl-(1 → 2)-α-L-arabinopyranoside (1), 13β,28-epoxy-16β,21β-dihydroxyolean-11-en-3β-yl O-β-D-[2-O-sulfate]-glucopyranosyl-(1 → 2)-α-L-arabinopyranosyl 21-O-{4-(secbutylamido)-butanoyl ester} (2) and 3-O-β-D-glucopyranosyl-(1 → 2)-β-D-galactopyranosyl saikogenin G (3). The cytotoxic activities of these compounds were evaluated against the HT-29 and HCT 116 human colon cancer cell lines.
    Glaucoside A Description
    Source: The roots of Cynanchum stauntonii
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9223 mL 9.6117 mL 19.2234 mL 38.4468 mL 48.0584 mL
    5 mM 0.3845 mL 1.9223 mL 3.8447 mL 7.6894 mL 9.6117 mL
    10 mM 0.1922 mL 0.9612 mL 1.9223 mL 3.8447 mL 4.8058 mL
    50 mM 0.0384 mL 0.1922 mL 0.3845 mL 0.7689 mL 0.9612 mL
    100 mM 0.0192 mL 0.0961 mL 0.1922 mL 0.3845 mL 0.4806 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Steroids . 2008 Jul;73(6):629-36.
    Steroidal glycosides from the roots of Cynanchum amplexicaule Sieb. et Zucc[Pubmed: 18343471]
    Seven new steroidal glycosides (amplexicosides A (4), B (7), C (8), D (9), E (10), F (11), and G (12)), along with six known compounds (cynatratoside A (1), tylophoside A (2), cynatratoside B (3), glaucogenin A (5), Glaucoside A (6), and hancoside A (13)) were isolated from the 95% ethanol extract of the roots of Cynanchum amplexicaule (Sieb. et Zucc.). Their structures were determined based on spectral and chemical evidence. Compound 12 has a 14, 15-secopregnane-type skeleton aglycone, which has not been reported in literature.
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