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    Natural Products
    29-Nor-20-oxolupeol
    29-Nor-20-oxolupeol
    Information
    CAS No. 19891-85-1 Price
    Catalog No.CFN96388Purity>=98%
    Molecular Weight428.7Type of CompoundTriterpenoids
    FormulaC29H48O2Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    29-Nor-20-oxolupeol

    29-Nor-20-oxolupeol
    Product Name 29-Nor-20-oxolupeol
    CAS No.: 19891-85-1
    Catalog No.: CFN96388
    Molecular Formula: C29H48O2
    Molecular Weight: 428.7 g/mol
    Purity: >=98%
    Type of Compound: Triterpenoids
    Physical Desc.: Powder
    Source: The herbs of Saussurea ussuriensis.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
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  • Front Microbiol.2020, 11:583594.
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
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  • Biological Activity
    Description: 29-Nor-20-oxolupeol(3 beta-Hydroxy-30-norlupan-20-one) has growth inhibitory effects on HL-60 cells.
    In vitro:
    Zhongguo Zhong Yao Za Zhi. 2008 Jun;33(12):1422-4.
    Studies on chemical constituents from Euonymus alatus II[Pubmed: 18837347]
    To study the chemical constituents and antitumor activities of Euonymus alatus.
    METHODS AND RESULTS:
    Compounds were isolated and purified repeatedly by silica gel, Sephadex LH-20 column chromatography, and their chemical structures were elucidated by their physicochemical properties and spectral data, such as 1H-NMR, 13C-NMR and EI-MS. The trypan blue experiments in vitro were used to observe the antitumor activity of several compounds. Ten compounds were obtained and identified as (+)-usnic acid (1), benzoic acid (2), 2-hydroxy-4-methoxy-3, 6-dimethyl benzoic acid (3), lupeol (4), 3 beta-hydroxy-30-norlupan-20-one (29-Nor-20-oxolupeol,5), (2R, 3R)-3, 5, 7, 4'-tetrahydroxy flavanone (6), kaempferol (7), 5, 7, 4'-trihydroxy flavanone (8), quercetin (9) and daucosterol (10).
    CONCLUSIONS:
    Compounds 1, 2, 5 and 8 were isolated from this genus for the first time. The trypan blue experiments in vitro showed that compounds 1, 4 and 5 had growth inhibitory effects on HL-60 cells.
    29-Nor-20-oxolupeol Description
    Source: The herbs of Saussurea ussuriensis.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3326 mL 11.6632 mL 23.3263 mL 46.6527 mL 58.3158 mL
    5 mM 0.4665 mL 2.3326 mL 4.6653 mL 9.3305 mL 11.6632 mL
    10 mM 0.2333 mL 1.1663 mL 2.3326 mL 4.6653 mL 5.8316 mL
    50 mM 0.0467 mL 0.2333 mL 0.4665 mL 0.9331 mL 1.1663 mL
    100 mM 0.0233 mL 0.1166 mL 0.2333 mL 0.4665 mL 0.5832 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Canadian Journal of Chemistry,2011,86(4):281-4.
    Triterpenoids from Saussurea ussuriensis[Reference: WebLink]

    METHODS AND RESULTS:
    From an extract of the whole plant of Saussurea ussuriensis, three new triterpenoids, 1β-hydroxy-ursa-9(11), 12-dien-3β-yl palmitate (ussuriensin A) (1), 1β-hydroxy-oleana-9(11), 12-dien-3β-yl palmitate (ussuriensin B) (2), and 28-hydroxy-taraxast-20(30)-ene-3β-yl palmitate (ussuriensin C) (3), as well as five known triterpenoids, 11β-hydroxy-urs-12-en-3-one (4), 11β-hydroxy-urs-12-en-3β-yl palmitate (5), ursa-9(11), 12-dien-3-one (marsformosanone) (6), 3β-hydroxy-30-norlupan-20-one (29-Nor-20-oxolupeol,7), and taraxast-20(30)-en-3β, 21α-diol (8) were isolated. Their structures were characterized by various spectroscopic methods, including 1D NMR, 2D NMR, and HR-ESI-MS.Key words: Compositae, Saussurea ussuriensis, triterpenoids, ursane, oleanane, taraxastane.
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