2-(2,4-Dihydroxyphenyl)-5,6-methylenedioxybenzofuran (ABF) | CAS:67121-26-0

2-(2,4-Dihydroxyphenyl)-5,6-methylenedioxybenzofuran (ABF)

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In vitro:

J Nat Prod . 1998 Sep;61(9):1146-1147.

Antimalarial principles from Artemisia indica[Pubmed: 9748386]

Activity-guided investigation of Artemisia indica Willd. has led to isolation of exiguaflavone A, exiguaflavone B, maackiain, and 2-(2, 4-dihydroxyphenyl)-5,6-methylenedioxybenzofuran. Exiguaflavones A and B exhibit in vitro antimalarial activities of 4.60 x 10(-6) and 7.05 x 10(-6) g/mL, respectively, against Plasmodium falciparum.

In vivo:

Xenobiotica . 2015;45(12):1092-1104.

Pharmacokinetic properties of trifolirhizin, (-)-maackiain, (-)-sophoranone and 2-(2,4-dihydroxyphenyl)-5,6-methylenedioxybenzofuran after intravenous and oral administration of Sophora tonkinensis extract in rats[Pubmed: 26068519]

1. SKI3301, a standardized dried 50% ethanolic extracts of Sophora tonkinensis, contains four marker compounds (trifolirhizin, TF; (-)-maackiain, Maack; (-)-sophoranone, SPN, and (2-(2,4-dihydroxyphenyl)-5,6-methylenedioxybenzofuran, ABF), is being developed as an herbal medicine for the treatment of asthma in Korea. This study investigates the pharmacokinetic properties of SKI3301 extract in rats. 2. The dose-proportional AUCs suggest linear pharmacokinetics of TF, Maack, SPN and ABF in the SKI3301 extract intravenous dose range of 5-20 mg/kg. After the oral administration of 200-1000 mg/kg of the extract, TF and Maack exhibited non-linearity due to the saturation of gastrointestinal absorption. However, linear pharmacokinetics of SPN and ABF were observed. 3. The absorptions of TF, Maack, SPN and ABF in the extract were increased relative to those of the respective pure forms due to the increased solubility and/or the decreased metabolism by other components in the SKI3301 extract. 4. No accumulation was observed after multiple dosing, and the steady-state pharmacokinetics of TF, Maack, SPN and ABF were not significantly different from those after a single oral administration of the extract. 5. The pharmacokinetics of TF, SPN and ABF were not significantly different between male and female rats after oral administration of the extract, but a significant gender difference in the pharmacokinetics of Maack in rats was observed. 6. Our findings may help to comprehensively elucidate the pharmacokinetic characteristics of TF, Maack, SPN and ABF and provide useful information for the clinical application of SKI3301 extract.

2-(2,4-Dihydroxyphenyl)-5,6-methylenedioxybenzofuran (ABF) Description

Source:	The rhizomes of Polygonum cuspidatum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

CAS No.	67121-26-0	Price	$318 / 5mg
Catalog No.	CFN95511	Purity	>=98%
Molecular Weight	270.2	Type of Compound	Phenols
Formula	C₁₅H₁₀O₅	Physical Description	Powder
Download	COA MSDS	Similar structural	Comparison (Web) (SDF)

Product Name	2-(2,4-Dihydroxyphenyl)-5,6-methylenedioxybenzofuran (ABF)
CAS No.:	67121-26-0
Catalog No.:	CFN95511
Molecular Formula:	C₁₅H₁₀O₅
Molecular Weight:	270.2 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The rhizomes of Polygonum cuspidatum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:	$318 / 5mg
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Phenols Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.701 mL	18.5048 mL	37.0096 mL	74.0192 mL	92.5241 mL
5 mM	0.7402 mL	3.701 mL	7.4019 mL	14.8038 mL	18.5048 mL
10 mM	0.3701 mL	1.8505 mL	3.701 mL	7.4019 mL	9.2524 mL
50 mM	0.074 mL	0.3701 mL	0.7402 mL	1.4804 mL	1.8505 mL
100 mM	0.037 mL	0.185 mL	0.3701 mL	0.7402 mL	0.9252 mL

CFN91100	Rhaponticin 2''-O-gallate	94356-24-8	572.51	C₂₈H₂₈O₁₃
CFN99995	2,3,5,4'-Tetrahydroxyl diphenylethylene-2-O-glucoside	82373-94-2	406.39	C₂₀H₂₂O₉
CFN98662	Pinostilbene	42438-89-1	242.3	C₁₅H₁₄O₃
CFN95285	1-(3',5'-dimethoxy)phenyl-2-[4''-O-beta-D-glucopyranosyl (6->1)-O-alpha-L-rhamnopyranosyl]phenylethane	1338076-61-1	566.6	C₂₈H₃₈O₁₂
CFN98995	Pinostilbenoside	58762-96-2	404.4	C₂₁H₂₄O₈
CFN92587	5-Methoxy-3-stilbenol	5150-38-9	226.3	C₁₅H₁₄O₂
CFN92783	Thunalbene	220862-05-5	242.3	C₁₅H₁₄O₃
CFN91176	3'-O-Methylbatatasin III	101330-69-2	258.3	C₁₆H₁₈O₃
CFN92689	Batatasin III	56684-87-8	244.3	C₁₅H₁₆O₃
CFN95319	Batatasin IV	60347-67-3	244.3	C₁₅H₁₆O₃