ChemFaces is a professional high-purity natural products manufacturer.
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2. Pharmacological research
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $222.6 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Environ Toxicol.2020, doi: 10.1002Drug Des Devel Ther.2020, 14:969-976.J Food Biochem.2021, 45(7):e13774. Tumour Biol.2015, 36(12):9385-93Int J Nanomedicine.2022, 17:6513-6525.Biomolecules.2021, 11(10):1537.Crystals2020, 10(3), 206.Asian J Beauty Cosmetol...2016...
Nat Prod Sci.2018, 24(2):109-114Dent Mater J.2020, 39(4):690-695Appl. Sci. 2021, 11(17),7829J Appl Pharm Sci.2022, 12(04):044-053Front Pharmacol.2021, 12:770667.Int J Biol Macromol.2020, 169:342-351Molecules.2021, 26(9):2765. Front Pharmacol.2021, 12:762829.
Nutrients.2019, 11(11):E2694J Pharmaceutical and Biomedical A...2022...Integr Cancer Ther.2018, 17(3):832-843Phytother Res.2022, 10.1002:ptr.7626.The Journal of Supercritical Flui...2021...Oncol Rep.2021, 46(2):166.Plants (Basel).2023, 12(1):163.
Our products had been exported to the following research institutions and universities, And still growing.
Vin?a Institute of Nuclear Scie... (Serbia)Heinrich-Heine-University Düss... (Germany)Kyung Hee University (Korea)The Ohio State University (USA)
University of Sao Paulo (Brazil)Siksha O Anusandhan University (India)University of Beira Interior (Portugal)National Cancer Institute (USA)
Universidad Veracuzana (Mexico)Charles Sturt University (Denmark)Helmholtz Zentrum München (Germany)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Food Funct.2020, 11(2):1322-1333.Food Chem.2022, 373(Pt B):131364.Korean Journal of Plant Resources2021, 34(1):52-58.The Japan Society for Analytical Chemistry2018, 67(4):201-206Toxicological Research2020, doi: 10.1007.Int J Nanomedicine.2022, 17:6513-6525.Molecules.2018, 23(3):E615Environ Toxicol.2019, 34(4):513-520.J AOAC Int.2021, 104(6):1634-1651.J Pharm Anal.2016, 6(6):363-373
Related Screening Libraries
|Size /Price /Stock
||10 mM * 100 uL in DMSO / Inquiry / In-stock |
10 mM * 1 mL in DMSO / Inquiry / In-stock
|J Nat Prod . 1998 Sep;61(9):1146-1147. |
|Antimalarial principles from Artemisia indica[Pubmed: 9748386]|
|Activity-guided investigation of Artemisia indica Willd. has led to isolation of exiguaflavone A, exiguaflavone B, maackiain, and 2-(2, 4-dihydroxyphenyl)-5,6-methylenedioxybenzofuran. Exiguaflavones A and B exhibit in vitro antimalarial activities of 4.60 x 10(-6) and 7.05 x 10(-6) g/mL, respectively, against Plasmodium falciparum.|
|Xenobiotica . 2015;45(12):1092-1104. |
|Pharmacokinetic properties of trifolirhizin, (-)-maackiain, (-)-sophoranone and 2-(2,4-dihydroxyphenyl)-5,6-methylenedioxybenzofuran after intravenous and oral administration of Sophora tonkinensis extract in rats[Pubmed: 26068519]|
|1. SKI3301, a standardized dried 50% ethanolic extracts of Sophora tonkinensis, contains four marker compounds (trifolirhizin, TF; (-)-maackiain, Maack; (-)-sophoranone, SPN, and (2-(2,4-dihydroxyphenyl)-5,6-methylenedioxybenzofuran, ABF), is being developed as an herbal medicine for the treatment of asthma in Korea. This study investigates the pharmacokinetic properties of SKI3301 extract in rats. 2. The dose-proportional AUCs suggest linear pharmacokinetics of TF, Maack, SPN and ABF in the SKI3301 extract intravenous dose range of 5-20 mg/kg. After the oral administration of 200-1000 mg/kg of the extract, TF and Maack exhibited non-linearity due to the saturation of gastrointestinal absorption. However, linear pharmacokinetics of SPN and ABF were observed. 3. The absorptions of TF, Maack, SPN and ABF in the extract were increased relative to those of the respective pure forms due to the increased solubility and/or the decreased metabolism by other components in the SKI3301 extract. 4. No accumulation was observed after multiple dosing, and the steady-state pharmacokinetics of TF, Maack, SPN and ABF were not significantly different from those after a single oral administration of the extract. 5. The pharmacokinetics of TF, SPN and ABF were not significantly different between male and female rats after oral administration of the extract, but a significant gender difference in the pharmacokinetics of Maack in rats was observed. 6. Our findings may help to comprehensively elucidate the pharmacokinetic characteristics of TF, Maack, SPN and ABF and provide useful information for the clinical application of SKI3301 extract.|
2-(2,4-Dihydroxyphenyl)-5,6-methylenedioxybenzofuran (ABF) Description
||The rhizomes of Polygonum cuspidatum
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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