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3. Inhibitors
3-O-beta-D-Glucopyranosylplatycodigenin
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $348.4 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Phytochemistry.2017, 141:162-170J Nat Prod.2015, 78(6):1339-4Curr Issues Mol Biol....2022...Arch Pharm Res.2015, 38(6):1080-9Chemistry of Natural Compounds...2019...Horticulture Research2022, uhac276.J Funct Foods2019, 54:449-456Plos One.2019, 15(2):e0220084
Antioxidants (Basel).2020, 9(6):466.The Journal of Agromedicine and M...2018...Molecules.2020, 25(18):4283.Appl Biol Chem2019, 62:46J. Soc. Cosmet. Sci. Korea2016, 163-171Food Sci Nutr.2019, 8(1):246-256Int J Mol Sci.2019, 20(11):E2734Pharmacol Rep.2022, 74(1):175-188.
New Journal of Chemistry...2019...Journal of Oil Palm Research...2019...Int J Mol Sci.2020, 21(22):8816. JEJU National University2022, 10478.Biochem Biophys Res Commun....2018...Eur J Neurosci.2021, 53(11):3548-3560.J Mol Med (Berl).2018, 96(7):661-672
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Osmania University (India)Johannes Gutenberg University M... (Germany)Monash University Malaysia (Malaysia)University of Parma (Italy)
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3-O-beta-D-Glucopyranosylplatycodigenin
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Front Pharmacol.2021, 12:652860. LWT2020, 110397Food Science and Human Wellness2022, 11(4):965-974Plants (Basel).2021, 10(11):2525.Molecules. 2013, 18(11):14105-21J Pharmacol Sci.2021, 147(2):184-191.Bulletin of Health Research2016, 44(4):279-286BMC Complement Altern Med.2019, 19(1):367J Hematol Oncol.2018, 11(1):112Foods. 2022, 11(23):3905.
Related Screening Libraries
| Description: |
3-O-beta-D-Glucopyranosylplatycodigenin may have in vitro anti-proliferative activity against the HSC-T6 cell line. |
| In vitro: |
| Molecules. 2012 Dec 13;17(12):14899-907. | | Two new oleanane-type triterpenoids from Platycodi Radix and anti-proliferative activity in HSC-T6 cells.[Pubmed: 23519261 ] |
METHODS AND RESULTS:
Two new oleanane-type triterpenoids, named platycodonoids A and B (1, 2), together with five known saponins, including platycodin D (3), deapioplatycodin D (4), 3-O-β-D-glucopyranosyl polygalacic acid (5), 3-O-beta-D-Glucopyranosylplatycodigenin (6) and polygalacin D (7), were isolated from the roots of Platycodon grandiflorum. On the basis of spectral data and chemical evidence, the structures of the new compounds were elucidated as 2β,3β,23,24-tetrahydroxy-28-nor-olean-12-en-16-one (1) and 2β,3β,23,24- tetrahydroxy-28-nor-olean-12-en-16-one-3-O-β-D-glucopyranoside (2).
CONCLUSIONS:
Compounds 1-7 were evaluated for their in vitro anti-proliferative activity against the HSC-T6 cell line. |
|
3-O-beta-D-Glucopyranosylplatycodigenin Description
| Source: |
The roots of Platycodon grandiflorum. |
| Solvent: |
DMSO, Pyridine, Methanol, Ethanol, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.4645 mL |
7.3223 mL |
14.6445 mL |
29.289 mL |
36.6113 mL |
| 5 mM |
0.2929 mL |
1.4645 mL |
2.9289 mL |
5.8578 mL |
7.3223 mL |
| 10 mM |
0.1464 mL |
0.7322 mL |
1.4645 mL |
2.9289 mL |
3.6611 mL |
| 50 mM |
0.0293 mL |
0.1464 mL |
0.2929 mL |
0.5858 mL |
0.7322 mL |
| 100 mM |
0.0146 mL |
0.0732 mL |
0.1464 mL |
0.2929 mL |
0.3661 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Structure Identification: |
| Zhongguo Zhong Yao Za Zhi. 2006 Sep;31(18):1506-9. | | Chemical constituents from roots of Platycodon grandiflorum.[Pubmed: 17144467] | To study the chemical constituents from roots of Platycodon grandiflorum.
METHODS AND RESULTS:
Column chromatography (silica gel, macroporous resin, sephadex LH - 20 and the preparative RP - HPLC were used to isolate the constituents. Their structures were elucidated by physical and spectral data. Eight compounds were isolated and identified as tangeritin (1), 3-O-beta-D-Glucopyranosylplatycodigenin methyl ester (2), 3-O-beta-D-glucopyranosylplaticogenic acid A lactone (3), 3-O-beta-D-Glucopyranosylplatycodigenin (4), deapio-platyconic acid A lactone (5), deapio-platycodin-D (6), platycoside-G1 (7) and platycoside-E (8).
CONCLUSIONS:
Compounds 1,3 and 5 were isolated from this plant for the first time. |
|
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