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Magnolignan A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Magnolignan A
Price: $318 / 10mg
CAS No.: 93673-81-5
Catalog No.: CFN96188
Molecular Formula: C18H20O4
Molecular Weight: 300.4 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Oil
Source: The barks of Magnolia officinalis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $175.7 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Magnolignan A-2-O-beta-D-glucopyranoside has medium cytotoxic activity against HEp-2 and HepG2 cells, with IC(50) of 13.3 microM, and 46.4 microM, respectively.
In vitro:
Magn Reson Chem. 2008 May;46(5):497-500.
1H and 13C NMR assignments for two lignans from the heartwood of Streblus asper.[Pubmed: 18297743 ]

METHODS AND RESULTS:
In our ongoing investigation of the bioactive constituents from plants, two new lignans, Magnolignan A-2-O-beta-D-glucopyranoside and strebluslignanol were isolated from heartwood of Streblus asper, along with three known lignans, Magnolignan A, magnolol, and magnaldehyde D. 1D and 2D NMR experiments, including COSY, HMQC, and HMBC, and other spectroscopic methods, including UV, IR, and MS were used for the determination of the structures and NMR assignments.
CONCLUSIONS:
Primary bioassays showed that Magnolignan A-2-O-beta-D-glucopyranoside and strebluslignanol have medium cytotoxic activity against HEp-2 and HepG2 cells, with IC(50) of 13.3 microM, 46.4 microM and 10.1 microM, 21.7 microM, respectively.
Magnolignan A Description
Source: The barks of Magnolia officinalis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.3289 mL 16.6445 mL 33.2889 mL 66.5779 mL 83.2224 mL
5 mM 0.6658 mL 3.3289 mL 6.6578 mL 13.3156 mL 16.6445 mL
10 mM 0.3329 mL 1.6644 mL 3.3289 mL 6.6578 mL 8.3222 mL
50 mM 0.0666 mL 0.3329 mL 0.6658 mL 1.3316 mL 1.6644 mL
100 mM 0.0333 mL 0.1664 mL 0.3329 mL 0.6658 mL 0.8322 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Natural Medicines, 1999 , 53 :1-4.
The simple method of distinction between Japanese and Chinese magnolia bark by ion-pair high-performance liquid chromatography using photodiode array detector[Reference: WebLink]
To establish a simple method for making distinction between Japanese and Chinese magnolia barks, the components in both magnolia barks were analysed by ion-pair high performance liquid chromatography using a photodiode array detector. Methyleugenol and Magnolignan A were detected only in Chinese magnolia barks. The presence or absence, of these components distinguishes Japanese magnolia barks from Chinese magnolia barks. The amounts these components in Chinese magnolia barks were determined.
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CAS No: 94805-82-0
Price: $268/10mg
Nimbolide

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CAS No: 25990-37-8
Price: $318/10mg
Ferulic acid

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Gypenoside XIII

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Delta 5-avenasterol

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Roemerine

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Allantoin

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Napellonine

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Supinine

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