3-beta-O-(trans-p-Coumaroyl)maslinic acid | CAS:35482-91-8

3-beta-O-(trans-p-Coumaroyl)maslinic acid

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Product Name	3-beta-O-(trans-p-Coumaroyl)maslinic acid
Price:
CAS No.:	35482-91-8
Catalog No.:	CFN92210
Molecular Formula:	C₃₉H₅₄O₆
Molecular Weight:	618.9 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	From Faeces Trogopterpri
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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Description:

3-beta-O-(trans-p-Coumaroyl)maslinic acid is a DNA polymerase B" inhibitor. It shows antimicrobial activity on Gram-positive bacteria and yeasts.

Targets:

DNA polymerase B" inhibitor | Antifection

In vitro:

Planta Medica, 2000, 66(8):768-769.

Antimicrobial triterpenoids from Licania heteromorpha.[Reference: WebLink]

METHODS AND RESULTS:
Six triterpenoids having a lupane and oleane skeleton were isolated from the leaves and young branches of Licania heteromorpha Bentham var. heteromorpha and were identified as: betulinic acid 1, alphitolic acid 2, 3 beta-O-trans-p-coumaroyl alphitolic acid 3, 3 beta-O-cis-p-coumaroyl alphitolic acid 4, 3-beta-O-(trans-p-Coumaroyl)maslinic acid 5, 3 beta-O-cis-p-coumaroyl maslinic acid 6. The antimicrobial activity of these compounds was evaluated in vitro on clinically isolated microorganisms employing a microdilution method.
CONCLUSIONS:
Compounds 2, 3, 5, and 6 showed antimicrobial activity on Gram-positive bacteria and yeasts, whereas none of the six triterpenoids were active against Gram-negative organisms.

Journal of Natural Products, 1999, 62(12):1660-1663.

DNA polymerase beta inhibitors from Tetracera boiviniana.[Reference: WebLink]

METHODS AND RESULTS:
Bioassay-guided fractionation of an active methyl ethyl ketone extract of Tetracera boiviniana, using a sensitive assay to monitor DNA polymerase beta inhibition, resulted in the isolation of three known triterpenoids, betulinic acid (1), 3-cis-p-coumaroyl maslinic acid (2), and 3-beta-O-(trans-p-Coumaroyl)maslinic acid (3).
CONCLUSIONS:
Compounds 1-3 inhibited DNA polymerase beta with IC50 values of 14, 15, and 4.2 microM in the presence of bovine serum albumin (BSA) and 6.5, 7.5, and 2.0 microM in the absence of BSA, respectively. Further, compounds 1-3 potentiated the effects of bleomycin in cultured P-388D1 cells.

3-beta-O-(trans-p-Coumaroyl)maslinic acid Description

Source:	From Faeces Trogopterpri
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Planta Medica, 1997, 63(1):47--50.

Isolation and Structural Elucidation of Acylated Pentacyclic Triterpenoids from the Leaves ofEucalyptus camaldulensisvar.obtusa.[Reference: WebLink]

METHODS AND RESULTS:
Ten pentacyclic triterpenoids including two new constituents, eucalyptic acid and eucalyptolic acid, and eight known compounds (ursolic acid lactone, betulinic acid, oleanolic acid, ursolic acid, 3-beta-O-cis-p-coumaroylalphitolic acid, alphitolic acid, 3-beta-O-trans-p-coumaroylalphitolic acid, and 3-beta-O-(trans-p-Coumaroyl)maslinic acid have been isolated from the fresh and uncrushed leaves of Eucalyptus camaldulensis var. obtusa. Their structures were elucidated through detailed 1D and 2D NMR studies. The new natural products were characterized as 2-alpha-hydroxy-3-beta-E-feruloyloxy-lup-20(29)-en-28-oic acid and 2-alpha-hydroxy-3-beta-E-feruloyloxy-olean-12-en-28-oic acid, respectively. Except for oleanolic acid, all the known compounds are hitherto unreported from this plant.
CONCLUSIONS:
This is the first report of the isolation of 2-oxygenated 3-O-acylated triterpenoids from Eucalyptus genus.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticomplementary Compound Library Antimicrobial Compound Library Triterpenoids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6158 mL	8.0788 mL	16.1577 mL	32.3154 mL	40.3942 mL
5 mM	0.3232 mL	1.6158 mL	3.2315 mL	6.4631 mL	8.0788 mL
10 mM	0.1616 mL	0.8079 mL	1.6158 mL	3.2315 mL	4.0394 mL
50 mM	0.0323 mL	0.1616 mL	0.3232 mL	0.6463 mL	0.8079 mL
100 mM	0.0162 mL	0.0808 mL	0.1616 mL	0.3232 mL	0.4039 mL

CFN98397	Arjunic acid	31298-06-3	488.7	C₃₀H₄₈O₅
CFN98690	Arjunolic acid	465-00-9	488.7	C₃₀H₄₈O₅
CFN95039	Arjungenin	58880-25-4	504.7	C₃₀H₄₈O₆
CFN96829	3-O-Coumaroylarjunolic acid	171864-20-3	634.85	C₃₉H₅₄O₇
CFN98310	2,3-Dihydroxy-12-oleanen-28-oic acid	26563-68-8	472.7	C₃₀H₄₈O₄
CFN99041	2,3,23-Trihydroxy-12-oleanen-28-oic acid	102519-34-6	488.7	C₃₀H₄₈O₅
CFN99628	2,3,24-Trihydroxyolean-12-en-28-oic acid	150821-16-2	488.7	C₃₀H₄₈O₅
CFN90314	Bayogenin	6989-24-8	488.70	C₃₀H₄₈O₅
CFN92819	Bayogenin methyl ester	22425-81-6	502.4	C₃₁H₅₀O₅
CFN91135	Caulophyllogenin	52936-64-8	488.7	C₃₀H₄₈O₅