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    Natural Products
    Akuammiline
    Information
    CAS No. 1897-26-3 Price
    Catalog No.CFN97900Purity>=98%
    Molecular Weight394.5Type of CompoundAlkaloids
    FormulaC23H26N2O4Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Akuammiline

    Akuammiline
    Product Name Akuammiline
    CAS No.: 1897-26-3
    Catalog No.: CFN97900
    Molecular Formula: C23H26N2O4
    Molecular Weight: 394.5 g/mol
    Purity: >=98%
    Type of Compound: Alkaloids
    Physical Desc.: Powder
    Source: The herbs of Rauvolfia verticillata
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Alkaloids Compound Library
  • Biological Activity
    Description: Standard reference
    In vitro:
    J Nat Prod. 2007 Nov;70(11):1783-9.
    Biologically active aspidofractinine, rhazinilam, akuammiline, and vincorine alkaloids from Kopsia.[Pubmed: 17939738]

    METHODS AND RESULTS:
    Eleven new indole alkaloids, in addition to the previously reported rhazinal (1), and 14 other known alkaloids, were obtained from the Malayan Kopsia singapurensis, viz., kopsiloscines A-F (2-7), 16-epikopsinine (8), kopsilongine- N-oxide (9), 16-epiAkuammiline (10), aspidophylline A (11), and vincophylline (12). The structures of these alkaloids were determined using NMR and MS analyses.
    CONCLUSIONS:
    Rhazinal (1), rhazinilam (17), and rhazinicine (18) showed appreciable cytotoxicity toward drug-sensitive as well as vincristine-resistant KB cells, while kopsiloscines A (2), B (3), and D (5) and aspidophylline A (11) were found to reverse drug-resistance in drug-resistant KB cells.
    Akuammiline Description
    Source: The herbs of Rauvolfia verticillata
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5349 mL 12.6743 mL 25.3485 mL 50.6971 mL 63.3714 mL
    5 mM 0.507 mL 2.5349 mL 5.0697 mL 10.1394 mL 12.6743 mL
    10 mM 0.2535 mL 1.2674 mL 2.5349 mL 5.0697 mL 6.3371 mL
    50 mM 0.0507 mL 0.2535 mL 0.507 mL 1.0139 mL 1.2674 mL
    100 mM 0.0253 mL 0.1267 mL 0.2535 mL 0.507 mL 0.6337 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Angew Chem Int Ed Engl. 2015 Jan 7;54(2):400-12.
    Cascade reactions: a driving force in akuammiline alkaloid total synthesis.[Pubmed: 25346244]
    The Akuammiline alkaloids are a family of intricate natural products which have received considerable attention from scientists worldwide.
    METHODS AND RESULTS:
    Despite the fact that many members of this alkaloid class were discovered over 50 years ago, synthetic chemistry has been unable to address their architectures until recently. This minireview provides a brief overview of the rich history of the Akuammiline alkaloids, including their isolation, structural features, biological activity, and proposed biosyntheses. Furthermore, several recently completed total syntheses are discussed in detail. These examples not only serve to highlight modern achievements in alkaloid total synthesis, but also demonstrate how the molecular scaffolds of the
    CONCLUSIONS:
    Akuammilines have provided inspiration for the discovery and implementation of innovative cascade reactions for the rapid assembly of complex structures.
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