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|Size /Price /Stock
||10 mM * 1 mL in DMSO / $92.8 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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Eur J Pharm Sci.2016, 94:33-45J Pharm Biomed Anal.2016, 129:50-59Food Res Int.2020, 133:109130.Antioxidants.2022, 11(3):592. ARPN Journal of Eng.& Applied Sci...2016...Korean j.of Pharm.2017, 70-76Mol Cell.2017, 68(4):673-685Plants (Basel).2021, 10(7):1376.
Korean Journal of Pharmacognosy...2018...Korean J. Medicinal Crop Sci....2022...Biol Pharm Bull.2018, 41(11):1645-1651Nutraceuticals2022, 2(3),150-161J Chromatogr A.2022, 1685:463640.Eur J Pharmacol.2020, 889:173589.FEBS J.2022, 10.1111:febs.16676.Evid Based Complement Alternat Me...2021...
Korean J Acupunct2020, 37:104-121Biomed Sci Letters.2020, 26:319-326Anesth Pain Med (Seoul)....2020...SBRAS2016, 12Journal of Life Science2018, 917-922Molecules.2019, 24(10):E1926Phytother Res.2015, 29(7):1088-96
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Biochem Pharmacol.2017, 130:10-20ACS Synth Biol.2022, doi: 10.1021.J Agric Food Chem.2019, 67(27):7748-7754Molecules.2020 ,25(16):3697.Antioxidants (Basel).2020, 9(2):E120Front Plant Sci.2017, 8:723Phytochem Anal.2016, 27(5):296-303PLoS One.2018, 13(3):e0193386Phytother Res.2018, 32(12):2551-2559Biotechnol Bioeng.2020, 117(7):2198-2208.
Related Screening Libraries
|Size /Price /Stock
||10 mM * 100 uL in DMSO / Inquiry / In-stock |
10 mM * 1 mL in DMSO / Inquiry / In-stock
||Coumarins Compound Library
|| The absorption and transport of angelol A and Angelol B are passive diffusion as the dominating process in Caco-2 cell monolayer model.|
|Zhong Xi Yi Jie He Xue Bao. 2008 Apr;6(4):392-8. |
|Absorption and transport of 6 coumarins isolated from the roots of Angelica pubescens f. biserrata in human Caco-2 cell monolayer model.[Pubmed: 18405608]|
|The absorption and transport of six coumarins were passive diffusion as the dominating process.
METHODS AND RESULTS:
The P(app) values of umbelliferone, osthole, columbianadin, columbianetin acetate, angelol A and Angelol B from AP to BL side were (2.679+/-0.263) x 10(-5), (1.306+/-0.324) x 10(-5), (0.595+/-0.086) x 10(-6), (2.930+/-0.410) x 10(-6), (1.532+/-0.444) x 10(-5) and (1.413+/-0.243) x 10(-5) cm/s, and from BL to AP side were (3.381+/-0.410) x 10(-5), (0.898+/-0.134) x 10(-5), (0.510+/-0.183) x 10(-6), (0.222+/-0.025) x 10(-6), (1.203+/-0.280) x 10(-5) and (0.754+/-0.092) x 10(-5) cm/s, respectively. In this assay, the P(app) value of propranolol was 2.18 x 10(-5) cm/s and the P(app) value of atenolol was 2.77 x 10(-7) cm/s. Among the 6 coumarins, the P(app) values of umbelliferone, osthole, angelol A and Angelol B from AP to BL side were identical with that of propranolol, and columbianadin and columbianetin acetate lied between propranolol and atenolol. When replaced the HBSS with EBSS, and iodoacetamide or MK-591 were used in the experiment, the P(app) of Angelol B had no statistical difference as compared with the control group. In the mean total recoveries, umbelliferone was (83.31+/-3.52)%, angelol A was (77.39+/-7.38)%, osthole, columbianadin and Angelol B were between 50% to 65%, and columbianetin acetate was lower than 10%. The accumulation rates of osthole and columbianadin in the Caco-2 cells were (36.15+/-5.87)% and (53.90+/-4.39)%, respectively.
The absorption and transport of umbelliferone, osthole, columbianadin, columbianetin acetate, angelol A and Angelol B are passive diffusion as the dominating process in Caco-2 cell monolayer model. Umbelliferone, osthole, angelol A and Angelol B are estimated to be highly absorbed compounds, and columbianadin and columbianetin acetate are estimated to be moderately absorbed compounds. In the Caco-2 cells, osthol and columbianadin appear to accumulate, and columbianetin acetate may be metabolized.
The absorption and transport of Angelol B are not influenced by the change of pH and the presence of iodoacetamide or MK571.
Angelol B Description
||The roots of Angelica sinensis
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|J Asian Nat Prod Res. 2009 Aug;11(8):698-703. |
|Novel coumarin and furan from the roots of Angelica pubescens f. biserrata.[Pubmed: 20183310 ]|
METHODS AND RESULTS:
A new natural coumarin, angepubebisin (1), and a new furan, angepubefurin (2), together with the five known compounds, umbelliferone, Angelol B (3), ulopterol (4), peucedanol (5), and scopoletin, were isolated from the roots of Angelica pubescens Maxim. f. biserrata Shan et Yuan.
The structures of angepubebisin (1) and known compounds were determined by spectroscopic methods, including IR, UV, EI-MS, HR-FTICR-MS, 1D-, and 2D-NMR spectral analyses, and angepubefurin (2) was determined by HR-FTICR-MS and X-ray diffraction analyses.
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