Apigenin 7-diglucuronide | CAS:74696-01-8

Apigenin 7-diglucuronide

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Apigenin 7-diglucuronide Description

Source:	The leaves of Turpinia arguya Seem.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Brain Res . 2017 May 15;1663:141-150.

Apigenin-7-diglucuronide protects retinas against bright light-induced photoreceptor degeneration through the inhibition of retinal oxidative stress and inflammation[Pubmed: 28336272]

Vision impairment in retinal degenerative diseases such as age-related macular degeneration is primarily associated with photoreceptor degeneration, in which oxidative stress and inflammatory responses are mechanistically involved as central players. Therapies with photoreceptor protective properties remain to be developed. Apigenin-7-diglucuronide (A7DG), a flavonoid glycoside, is present in an assortment of medicinal plants with anti-inflammatory or ant-oxidant activities. However, the pharmacological significance of A7DG remains unknown in vivo. The current study isolated A7DG from Glechoma longituba (Nakai) Kuprian and investigated the retinal protective effect A7DG in mice characterized by bright light-induced photoreceptor degeneration. The results showed that A7DG treatment led to remarkable photoreceptor protection in bright light-exposed BALB/c mice. Moreover, A7DG treatment alleviated photoreceptor apoptosis, mitigated oxidative stress, suppressed reactive gliosis and microglial activation and attenuated the expression of proinflammatory genes in bright light-exposed retinas. The results demonstrated for the first time remarkable photoreceptor protective activities of A7DG in vivo. Inhibition of bright light-induced retinal oxidative stress and retinal inflammatory responses was associated with the retinal protection conferred by A7DG. The work here warrants further evaluation of A7DG as a pharmacological candidate for the treatment of vision-threatening retinal degenerative disorders. Moreover, given the general implication of oxidative stress and inflammation in the pathogenesis of neurodegeneration, A7DG could be further tested for the treatment of other neurodegenerative disorders.

Product Name	Apigenin 7-diglucuronide
Price:
CAS No.:	74696-01-8
Catalog No.:	CFN91599
Molecular Formula:	C₂₇H₂₆O₁₇
Molecular Weight:	622.5 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The leaves of Turpinia arguya Seem.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6064 mL	8.0321 mL	16.0643 mL	32.1285 mL	40.1606 mL
5 mM	0.3213 mL	1.6064 mL	3.2129 mL	6.4257 mL	8.0321 mL
10 mM	0.1606 mL	0.8032 mL	1.6064 mL	3.2129 mL	4.0161 mL
50 mM	0.0321 mL	0.1606 mL	0.3213 mL	0.6426 mL	0.8032 mL
100 mM	0.0161 mL	0.0803 mL	0.1606 mL	0.3213 mL	0.4016 mL

CFN92764	Tilianin	4291-60-5	446.1	C₂₂H₂₂O₁₀
CFN91439	Acacetin-7-O-6''-malonylglucoside	155049-92-6	532.5	C₂₅H₂₄O₁₃
CFN98738	Linarin	480-36-4	592.6	C₂₈H₃₂O₁₄
CFN70305	Fortunellin	20633-93-6	592.6	C₂₈H₃₂O₁₄
CFN95932	Acacetin 7-O-glucuronide	38226-83-4	460.4	C₂₂H₂₀O₁₁
CFN95358	Acacetin 7-[rhamnosyl-(1->2)-galacturonide]	38722-95-1	606.5	C₂₈H₃₀O₁₅
CFN95640	Neobudofficide	194602-91-0	738.7	C₃₄H₄₂O₁₈
CFN95315	Fortunellin-6''-beta-D-glucopyranoside (Acacetin-7-O-[2''-O-rhamnosyl-6''-O-glucosyl]-glucoside)	1218774-64-1	754.7	C₃₄H₄₂O₁₉
CFN99900	7,4-Di-O-methylapigenin 5-O-glucoside	197018-71-6	460.4	C₂₃H₂₄O₁₀
CFN98099	7,4'-Di-O-methylapigenin 5-O-xylosylglucoside	221257-06-3	592.6	C₂₈H₃₂O₁₄