Info: Read More
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • How to Order
  • Delivery time
  • Science | Nature | Cell | View More
    Natural Products
    Beta-Elemonic acid
    Beta-Elemonic acid
    Information
    CAS No. 28282-25-9 Price $198 / 20mg
    Catalog No.CFN90991Purity>=98%
    Molecular Weight454.7Type of CompoundTriterpenoids
    FormulaC30H46O3Physical DescriptionPowder
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $83.7 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Weizmann Institute of Science (Israel)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Guangzhou Institutes of Biomedi... (China)
  • Aarhus University (Denmark)
  • Washington State University (USA)
  • Hamdard University (India)
  • University of Limpopo (South Africa)
  • Korea Intitute of Science and T... (Korea)
  • Florida International University (USA)
  • Institute of Pathophysiology Me... (Austria)
  • Universidad Miguel Hernández (Spain)
  • More...
  • Package
    Featured Products
    Przewaquinone A

    Catalog No: CFN92022
    CAS No: 76843-23-7
    Price: $338/5mg
    Kaempferol 3-O-(6''-galloyl)-beta-...

    Catalog No: CFN92383
    CAS No: 56317-05-6
    Price: $533/5mg
    Kumatakenin

    Catalog No: CFN98423
    CAS No: 3301-49-3
    Price: $238/10mg
    Tubuloside A

    Catalog No: CFN90669
    CAS No: 112516-05-9
    Price: $/mg
    Isoquercitrin

    Catalog No: CFN98753
    CAS No: 482-35-9
    Price: $40/20mg
    Isochamaejasmine

    Catalog No: CFN92150
    CAS No: 93859-63-3
    Price: $418/5mg
    4-O-Feruloylquinic acid

    Catalog No: CFN92392
    CAS No: 2613-86-7
    Price: $448/5mg

    Beta-Elemonic acid

    Beta-Elemonic acid
    Product Name Beta-Elemonic acid
    CAS No.: 28282-25-9
    Catalog No.: CFN90991
    Molecular Formula: C30H46O3
    Molecular Weight: 454.7 g/mol
    Purity: >=98%
    Type of Compound: Triterpenoids
    Physical Desc.: Powder
    Targets: MAPK | ROS | COX | Bcl-2/Bax
    Source: The sclerotium of Poria cocos (Schw.) Wolf
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $198 / 20mg
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    Address:
    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • Food and Bioprocess Technology2017, 10(6):1074-1092
  • TCI CO.2019, US20190151281A1
  • Nat Prod Sci.2018, 24(3):206
  • Food and Fermentation Industries2018, 44(371)
  • Acta Biochim Pol.2015, 62(2):253-8
  • Am J Chin Med.2016, 44(8):1719-1735
  • Nat Prod Commun.2017, 12(5):771-778
  • Drug Des Devel Ther.2020, 14:5189-5204.
  • Int Immunopharmacol.2020, 90:107268.
  • Jour. of Stored Pro & Postharvest Res.2016, 7(3):32-36
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anti-inflammatory Compound Library
  • Inhibitors Compound Library
  • Anti-proliferation Compound Library
  • Triterpenoids Compound Library
  • ROS Inhibitor Library
  • MAPK Inhibitor Library
  • COX Inhibitor Library
  • Bcl-2/Bax Inhibitor Library
  • Biological Activity
    Description: Beta-Elemonic acid exhibits anti-inflammatory, and anti-cancer effects, it inhibits proliferation by inducing hypoploid cells and cell apoptosis, the anticancer effects of beta-Elemonic acid are related to the MAPK signaling pathway, ROS activation and glutathione depletion in human A549 lung cancer cells. Beta-Elemonic acid exhibits prolyl endopeptidase inhibitory activities.
    Targets: MAPK | ROS | COX | Bcl-2/Bax
    In vitro:
    Oncol Rep. 2016 Jan;35(1):227-34.
    β-Elemonic acid inhibits the cell proliferation of human lung adenocarcinoma A549 cells: The role of MAPK, ROS activation and glutathione depletion.[Pubmed: 26530631 ]
    Beta-Elemonic acid, a known triterpene, exhibits anti-inflammatory effects, yet research on the pharmacological effects of Beta-Elemonic acid is rare.
    METHODS AND RESULTS:
    We investigated the anticancer effects and the related molecular mechanisms of Beta-Elemonic acid on human non-small cell lung cancer (NSCLC) A549 cells. The effects of Beta-Elemonic acid on the growth of A549 cells were studied using a 3-(4,5)-2,5-diphenyltetrazolium bromide (MTT) assay. Apoptosis was detected using Annexin V staining. The effect of Beta-Elemonic acid on the cell cycle of A549 cells was assessed using the propidium iodide method. The change in reactive oxygen species (ROS) was detected using a dichlorodihydrofluorescein diacetate (DCFH-DA) assay with microscopic examination. The expression levels of Bcl-2 family proteins, mitogen-activated protein kinase (MAPK) family proteins and cyclooxygenase 2 (COX-2) were detected using western blot analysis. Our data revealed that β-elemonic acid strongly induced human A549 lung cancer cell death in a dose- and time-dependent manner as determined by the MTT assay. Beta-Elemonic acid-induced cell death was considered to be apoptotic when the phosphatidylserine exposure was observed using Annexin V staining. The death of human A549 lung cancer cells was caused by apoptosis induced by activation of ROS activity, increase in the sub-G1 proportion, downregulation of Bcl-2 expression, upregulation of Bax expression and inhibition of the MAPK signaling pathways.
    CONCLUSIONS:
    These results clearly demonstrated that Beta-Elemonic acid inhibits proliferation by inducing hypoploid cells and cell apoptosis. Moreover, the anticancer effects of Beta-Elemonic acid were related to the MAPK signaling pathway, ROS activation and glutathione depletion in human A549 lung cancer cells.
    Beta-Elemonic acid Description
    Source: The sclerotium of Poria cocos (Schw.) Wolf
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds
    3,4-Di-O-caffeoylquinic acid methy...

    Catalog No: CFN90856
    CAS No: 114637-83-1
    Price: $388/5mg
    (R)-O-isobutyroyllomatin

    Catalog No: CFN95250
    CAS No: 440094-38-2
    Price: $413/5mg
    Kaempferol 7-O-rhamnoside

    Catalog No: CFN96224
    CAS No: 20196-89-8
    Price: $338/10mg
    Safflospermidine B

    Catalog No: CFN95254
    CAS No: N/A
    Price: $413/5mg
    Mirificin-4'-O-glucoside

    Catalog No: CFN95091
    CAS No: 168035-01-6
    Price: $288/5mg
    Verbasoside

    Catalog No: CFN95015
    CAS No: 61548-34-3
    Price: $368/5mg
    2-Hydroxy-3-methoxybenzoic acid gl...

    Catalog No: CFN89113
    CAS No: 172377-87-6
    Price: $268/5mg
    Magnolignan C

    Catalog No: CFN96189
    CAS No: 93697-42-8
    Price: $413/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1993 mL 10.9963 mL 21.9925 mL 43.985 mL 54.9813 mL
    5 mM 0.4399 mL 2.1993 mL 4.3985 mL 8.797 mL 10.9963 mL
    10 mM 0.2199 mL 1.0996 mL 2.1993 mL 4.3985 mL 5.4981 mL
    50 mM 0.044 mL 0.2199 mL 0.4399 mL 0.8797 mL 1.0996 mL
    100 mM 0.022 mL 0.11 mL 0.2199 mL 0.4399 mL 0.5498 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Nat Prod. 2005 Feb;68(2):189-93.
    Bioactive constituents from Boswellia papyrifera.[Pubmed: 15730241 ]

    METHODS AND RESULTS:
    Phytochemical investigation of the stem bark extract of Boswellia papyrifera afforded two new stilbene glycosides, trans-4',5-dihydroxy-3-methoxystilbene-5-O-{alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside (1), trans-4',5-dihydroxy-3-methoxystilbene-5-O-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside (2), and a new triterpene, 3alpha-acetoxy-27-hydroxylup-20(29)-en-24-oic acid (3), along with five known compounds, 11-keto-beta-boswellic acid (4), Beta-Elemonic acid (7), 3alpha-acetoxy-11-keto-beta-boswellic acid (8), beta-boswellic acid (9), and beta-sitosterol (10).
    CONCLUSIONS:
    The stilbene glycosides exhibited significant inhibition of phosphodiesterase I and xanthine oxidase. The triterpenes (3-9) exhibited prolyl endopeptidase inhibitory activities.
    Przewaquinone A

    Catalog No: CFN92022
    CAS No: 76843-23-7
    Price: $338/5mg
    Kaempferol 3-O-(6''-galloyl)-beta-...

    Catalog No: CFN92383
    CAS No: 56317-05-6
    Price: $533/5mg
    Kumatakenin

    Catalog No: CFN98423
    CAS No: 3301-49-3
    Price: $238/10mg
    Tubuloside A

    Catalog No: CFN90669
    CAS No: 112516-05-9
    Price: $/mg
    Isoquercitrin

    Catalog No: CFN98753
    CAS No: 482-35-9
    Price: $40/20mg
    Isochamaejasmine

    Catalog No: CFN92150
    CAS No: 93859-63-3
    Price: $418/5mg
    4-O-Feruloylquinic acid

    Catalog No: CFN92392
    CAS No: 2613-86-7
    Price: $448/5mg